英文药名：Irricolon M Tablets（Pipethanate Hydrochloride）
中文药名：盐酸哌苯乙醇组合片
日本药名：イリコロンM配合錠
生产厂家：日本新药
治疗类别名称
应激性胃肠病治疗剂
1. Pipetanato盐酸盐
一般名
ピペタナート塩酸塩 (Pipethanate Hydrochloride)(JAN)
化学名
2-Piperidinoethyl benzilate hydrochloride
分子式
C21H25NO3・HCl
分子量
375.89
化学構造式 
性状
本品是一种白色结晶或结晶性粉末，无异味。
该产品是微溶于甲醇，水，乙酸（100）或略少溶于二氯甲烷，乙酸酐，和微溶于乙醇（95）或丙酮，1-丁醇或二乙醚几乎不溶。
熔点
175〜178℃
2.野桐提取物
野桐（楸Muell 精氨酸）是从干树皮提取的提取物的棕色粉末。它有一个特殊的气味和味道，易溶于轻微浑浊的水。
药效药理
1. 对胃肠道的影响
野桐提取物软化盲肠，大肠和粪便中的内容，以促进排便（小鼠）。另一方面，显示了对实验泻剂的constipating动作由蓖麻油和氯化汞（小鼠）。
Pipetanato盐酸乙酰胆碱，氯化钡，组胺，通过毛果芸香碱抑制切除肠道的收缩（鼠标器，大鼠，豚鼠，兔，胃液，抑制胃酸的分泌（幽门结扎大鼠）。
此外，蓖麻油泻剂抑制作用，Irikoron中号组合片剂和样品的同一组成比[Pipetanato盐酸盐：粗糠提取= 1.5：70.0（重量比）]，当与Pipetanato盐酸盐和野桐提取物相比，即通过共混行动，加强（小鼠））。
2. 中枢的作用
Pipetanato盐酸显示了应力状态的动物一个安静的行为（大鼠），甲基六苦吉隆坡（鼠标延长麻醉时间）。
适应症
肠易激综合征（大肠过敏症）
剂量和给药方法
成人口服给药；一次二片，一天三次。此外，增加或减少取决于患者的年龄和症状。
包装规格
组合片剂
PTP 1000片
瓶：100粒，500粒
*制造商
日本新药有限公司
Irricolon M Tablets（Pipethanate Hydrochloride）イリコロンM配合錠
Brand name : Irricolon M Tablets
Active ingredient: Pipethanate hydrochloride
Mallotus bark extract
Dosage form: pale yellow tablet, major axis: 11.7 mm, minor axis: 7.3 mm, thickness: 5.1 mm
Print on wrapping: 204, イリコロンM配合錠
Effects of this medicine
This medicine has effects to promote bowel movement and to stop diarrhea. It also suppresses constriction of intestinal tracts and secretion of gastric juice and gastric acid. It acts on the brain and shows effects to sedate symptoms caused by stress, and to extend anesthetic period.
It is usually used in the treatment of irritable colon.
Before using this medicine, be sure to tell your doctor and pharmacist
If you ever experienced any allergic reaction (itch, rash etc.) to any medicine.
If you are a patient with glaucoma, prostatic hyperplasia, cardiac disease, paralytic ileus, hyperthyroidism or ulcerative colitis.
If you are in a hot environment.
If you are pregnant or breastfeeding.
If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
General dosage regimen: For adults, take 2 tablets at a time, three times daily. The dosage may be adjusted according to the age or symptoms. Strictly follow the instructions of your doctor/pharmacist.
Take a dose as soon as possible. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. DO NOT take double doses to make up for the missed dose.
If you took too much of the medicine (more than ordered), check with your doctor/pharmacist.
Do not stop taking the medicine without the instructions of your doctor.
Precautions while taking this medicine
The medicine may cause difficulty in eye focusing and sleepiness. Avoid operating dangerous machinery or driving a car.
Possible adverse reactions to this medicine
Common side effects are reported as below. If any of them occurs, check with your doctor/pharmacist: hypersensitivity symptoms such as rash, sleepiness, nausea, constipation, borborygmus, etc.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
No pertinent entries.
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
Discard the remainder. Do not store them.
Nippon Shinyaku Co., Ltd. Internal
Published: 12/2009
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
http://www.info.pmda.go.jp/go/pack/2399100F1057_1_02/2399100F1057_1_02?view=body#23