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当前位置:药品说明书与价格首页 >> 呼吸系统病 >> 其他类用药 >> Meptin inhalation solution(盐酸丙卡特罗吸入溶液)

Meptin inhalation solution(盐酸丙卡特罗吸入溶液)

2015-10-13 11:44:01  作者:新特药房  来源:互联网  浏览次数:2  文字大小:【】【】【
简介: 英文药名:Meptin inhalation solution(Procaterol Hydrochloride Hydrate) 中文药名:盐酸丙卡特罗吸入溶液 生产厂家:大冢制药治疗类别名称支气管扩张一般名プロカテロール塩酸塩水和物〔Procate ...

英文药名:Meptin inhalation solution(Procaterol Hydrochloride Hydrate)

中文药名:盐酸丙卡特罗吸入溶液

生产厂家:大冢制药
治疗类别名称
支气管扩张
一般名
プロカテロール塩酸塩水和物〔Procaterol Hydrochloride Hydrate(JAN)〕
化学名
8-Hydroxy-5-{(1RS,2SR)-1-hydroxy-2-[(1-methylethyl)amino]butyl}quinolin-2(1H)-one monohydrochloride hemihydrate
構造式


分子式
C16H22N2O3・HCl・1/2H2O
分子量
335.83
性状
白色是一个很好的淡黄白色结晶或结晶性粉末。水,微溶于甲酸或甲醇,微溶于乙醇(95),并在乙醚中几乎不溶。本品1.0g溶解于水100毫升,该液体的pH为4.0至5.0。彩色逐渐被光。溶液(1→20)示出了没有旋光性。
熔点:
约195℃(分解)
药效药理
1.支气管扩张
(1) 通过抑制犬、猫和豚鼠的气道阻力增加的效果来看,盐酸丙卡特罗的支气管扩张作用与异丙肾上腺素相同或更强,强于沙丁胺醇及间羟异丙肾上腺素。
(2) 支气管扩张作用期间丙卡特罗盐酸盐水合物吸入意识豚鼠和麻醉狗的表达,在吸入后1-5分钟,迅速与口服给药相比。
(3) 由丙卡特罗盐酸盐水合物吸入,末梢气道也已证实,扩张不儿童患者支气管哮喘的仅中心气道
2.支气管扩张持续时间
(1) 丙卡特罗盐酸盐水合物动作的支气管扩张持续时间,研究了猫和豚鼠,异丙肾上腺素,trimetoquinol,已经证实长于奥西那林硫酸盐和硫酸沙丁胺醇
(2) 丙卡特罗盐酸盐水合物10μg的吸入麻醉狗抑制作用组胺气道阻力增加,示出了吸入和硫酸沙丁胺醇为200μg相同程度的抑制效果,作用持续时间较长
3. 选择性的β2受体
当器官选择性β受体β心血管系统的受体和呼吸道系统,研究了狗,猫,豚鼠,盐酸丙卡特罗水合物是异丙肾上腺素,trimetoquinol,奥西那林硫酸盐和硫酸沙丁胺醇它表现出优异的器官选择性比。
4.抗过敏作用
豚鼠或大鼠,PCA反应和组胺释放从肺中,丙卡特罗盐酸盐水合物,它被用作对皮肤反应和过敏原吸入激发在成年支气管哮喘患者异丙肾上腺素抑制的指标抗过敏作用增加气道阻力的Reaginic已经证实比奥西那林硫酸盐和硫酸沙丁胺醇更强。
5.对呼吸道分泌系统效果
盐酸丙卡特罗水合物,增强鸽子的呼吸道纤毛运动。
6.实验诱发哮喘发作的抑制作用
盐酸丙卡特罗水合跑步机或测力计锻炼和抑制乙酰甲胆碱诱发吸入性哮喘发作的支气管哮喘患者。
适应症
本品缓解下述疾病的呼吸道阻塞性障碍引起的呼吸困难等症状:
支气管哮喘、慢性支气管炎、急性支气管炎、喘息性支气管炎。
用法用量
一般成人一次30〜50μg的(0.3〜0.5毫升),和吸入使用喷雾器,同时深呼吸孩子一次10〜30μg的(0.1〜0.3毫升)。此外,增加或减少取决于患者的年龄和症状。
包装规格
Meptin吸入溶液0.01% 30ml×1瓶


Meptin吸入溶液:0.3毫升   0.3毫升×56个(28×2)


Meptin吸入溶液:0.5毫升: 0.5毫升×56个(28×2)


生产厂商
大冢制药有限公司


MEPTIN Inhalation Solution(Procaterol hydrochloride hydrate)
MEPTIN Inhalation Solution 0.01%
(メプチン吸入液0.01%)
Brand name : MEPTIN Inhalation Solution 0.01%
 Active ingredient: Procaterol hydrochloride hydrate
 Dosage form: colorless, clear liquid
 Print on wrapping: 
MEPTIN Inhalation Solution 0.3 mL Unit(メプチン吸入液ユニット0.3mL)
Brand name : MEPTIN Inhalation Solution 0.3 mL Unit
 Active ingredient: Procaterol hydrochloride hydrate
 Dosage form: colorless, clear liquid, blue plastic ampule
 Print on wrapping: 
MEPTIN Inhalation Solution 0.5 mL Unit(メプチン吸入液ユニット0.5mL) 
Brand name : MEPTIN Inhalation Solution 0.5 mL Unit
 Active ingredient: Procaterol hydrochloride hydrate
 Dosage form: colorless, clear liquid, colorless plastic ampule
 Print on wrapping: 
Effects of this medicine
This medicine dilates the bronchi to allow easier breathing.
It is usually used to improve symptoms (breathing difficulty, etc.) of bronchial asthma, chronic bronchitis, or pulmonary emphysema.
Before using this medicine, be sure to tell your doctor and pharmacist
If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you are pregnant or breastfeeding.
If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
In general, for adults, inhale 0.3 to 0.5 mL (30 to 50 mcg of active ingredient), and for children, inhale 0.1 to 0.3 mL (10 to 30 mcg of active ingredient) at a time by using the nebulizer while taking a deep breath. The dosage may be adjusted according to your disease, age, or symptoms. This medicine contains 0.5 mL per unit. Strictly follow the inhaling procedures as instructed by your doctor or pharmacist.
Follow the instructions of your doctor or pharmacist and carefully read the Guidance for Proper Use of Meptin Inhalation Solution 0.3 mL and 0.5 mL Unit-doses (Japanese only) before use.
Always gargle after inhaling this medicine.
Be careful not to put the medicine in the eyes or drink it.
This medicine must only be used with the nebulizer.
Never inhale 2 doses at one time.
If you accidentally use more than your prescribed dose, consult with your doctor or pharmacist.
Do not stop using this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include palpitation, tachycardia, tremor, headache/dull headache, nausea/vomiting, rash and itch. If any of these symptoms occurs, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
cold sweat, decreased blood pressure, respiratory distress [shock]
swelling around the eyes or mouth, hives, respiratory distress [anaphylaxis]
lassitude, respiratory distress, dry mouth [serious decrease in serum potassium]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
Keep out of the reach of children. Store away from light and heat.
If there is a remainder, this is to be discarded. Do not store it.
Otsuka Pharmaceutical Co., Ltd. External
Revised: 2/2014
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
http://www.info.pmda.go.jp/go/pack/2259704G1032_1_11/

责任编辑:admin


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