英文药名：INOVAN Injection（Dopamine Hydrochloride）
中文药名：盐酸多巴胺注射剂
生产厂家：协和发酵麒麟
イノバン注50mg／イノバン注100mg／イノバン注200mg
治疗类别名称
急性循环衰竭改善剂
欧文商標名
INOVAN Injection
一般名
ドパミン塩酸塩 Dopamine Hydrochloride
化学名
4-（2-Aminoethyl）benzene-1, 2-diol monohydrochloride
分子式
C8H11NO2・HCI＝189.64
化学構造式
性状
它是一种白色晶体或结晶粉末
溶解性
它是易溶于水或甲酸，稍微溶于乙醇（95）。
pH值
4.0〜5.5（1→50）
熔点
关于248℃（分解）
分配系数
logP'OCT=-2.3[测量方法：摇瓶法，正辛醇/pH7.4缓冲溶液]
药效药理
1.心脏收缩力增强
冠状动脉血流量，主动脉血流量和LVDP/ dt的成比例地增加剂量。
2.肾血流量增大的影响
为了增加通过多巴胺受体肾血流量
3.肠系膜血流增加作用
通过增加多巴胺受体在小肠上部之间的Makuchi流。
4.血压升高作用
它提出了血压由于增加心输出量。
适应症
急性循环衰竭（心源性休克，出血性休克）用于急性循环衰竭的条件下，如以下内容。
(1) 无尿，利尿不能在少尿和利尿剂获得
(2) 脉率增加的状态
(3) 或副作用是由其他心脏促进剂，无法获得较好的反应可以观察到的状态
用法用量
通常多巴胺持续1〜5μg的/公斤每分钟的盐酸盐静脉内给药，它可以被增加至20微克/千克取决于患者的病情。
剂量病人的血压，它是根据脉冲速率和尿液的量来调节。
包装规格
Inoban注：50mg：10管
Inoban注：100mg 50管
Inoban注：200mg 10管
生产厂商
协和发酵麒麟有限公司
INOVAN Injection（Dopamine hydrochloride）
INOVAN Injection 50 mg（イノバン注50mg）
Brand name : INOVAN Injection 50 mg
Active ingredient: Dopamine hydrochloride
Dosage form: injection
Print on wrapping:
INOVAN Injection 100 mg（イノバン注100mg）
Brand name : INOVAN Injection 100 mg
Active ingredient: Dopamine hydrochloride
Dosage form: injection
Print on wrapping:
INOVAN Injection 200 mg（イノバン注200mg）
Brand name : INOVAN Injection 200 mg
Active ingredient: Dopamine hydrochloride
Dosage form: injection
Print on wrapping:
Effects of this medicine
This medicine increases blood pressure by enhancing cardiac contractility and also increases urine output by increasing blood flow in the kidneys.
It is usually used for the treatment of acute circulatory failure (cardiogenic shock, hemorrhagic shock).
Before using this medicine, be sure to tell your doctor and pharmacist
If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have phaeochromocytoma, peripheral vascular disorder (diabetes mellitus, alcohol poisoning, frostbite, arteriosclerosis, Raynaud's syndrome or Buerger's disease), tachyarrhythmia, ventricular fibrillation.
If you are pregnant or breastfeeding.
If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
In general, this medicine is administered by intravenous infusion.
Dosing period is determined depending on symptoms and effects.
Precautions while taking this medicine
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include arrhythmia, limbs coldness, vomiting, palpitation, nausea, abdominal bloating, abdominal pain, phlebitis, injection site degenerative necrosis and piloerection. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
nausea, vomiting, intense abdominal pain, no output of stool [paralytic ileus]
coldness of limbs, facial pallor, numbness [limbs coldness, peripheral ischemia]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
Kyowa Hakko Kirin Co.,Ltd Injection
Published: 7/2013
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
http://www.info.pmda.go.jp/go/pack/2119402A1299_1_09/2119402A1299_1_09?view=body#21