英文药名：Nizoral Lotion 2％（ketoconazole）

中文药名：酮康唑乳液2％

生产厂家：杨森制药

ニゾラールローション2％

治疗类别名称
外用抗真菌剂
商標名
Nizoral Lotion 2％
一般名
ケトコナゾール（ketoconazole）
化学名
1-Acetyl-4-(4-{[(2RS,4SR)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine
分子式
C26H28Cl2N4O4
分子量
531.43
化学構造式

性状
白色至淡黄白色粉末，没有异味。
可溶性
乙酸（100）或可溶于氯仿，微溶于甲醇，微溶于乙醇（99.5），丙酮或2-丙醇微溶，并在二乙醚或几乎不溶于水。
熔点
148〜152℃
操作注意事项
放在儿童不能接触的地方。
适应病症
下面的皮肤真菌病的治疗
（1）癣
足癣，股癣，体癣
（2）皮肤念珠菌病
糜烂疾病的手指，擦烂（包括婴儿寄生菌性红斑）
（3）花斑癣
（4）脂溢性皮炎
用法用量
癣，皮肤念珠菌病，对于花斑癣，每天外擦一次。
对脂溢性皮炎，每天外擦二次。
药效药理
1. 抗真菌作用
酮康唑是皮肤癣菌（毛癣菌，小孢子菌属，表皮癣菌属），酵母菌（念珠菌），显示出对糠秕马拉色菌（糠秕马拉色菌）具有很强的抗真菌作用。
2. 实验治疗效果
对豚鼠实验癣（须癣毛癣菌感染）模型，在实验中，该酮康唑洗剂感染后涂抹一次从7天，每天，它表现在两周申请的高治疗效果。也显示出即使是同样豚鼠实验性念珠菌病（白色念珠菌感染）模型优越的治疗效果。
3. 作用机序
通过麦角甾醇的生物合成的抑制作用是细胞膜的真菌的成分的抗真菌作用。
包装规格
10g×10
制造厂商

杨森制药有限公司
Brand name : Nizoral Lotion 2%
　Active ingredient: Ketoconazole
　Dosage form: white lotion
　Print on wrapping: 
Effects of this medicine
This medicine shows anti-mycotic action by inhibiting biosynthesis of cell membrane of fungus (a kind of mold) to suppress the growth of fungus that is responsible to infectious diseases.
Usually, used for treatment of fungal infections of the skin (tinea, cutaneous candidiasis, chromophytosis, seborrheic dermatitis).
Before using this medicine, be sure to tell your doctor and pharmacist
•If you ever experienced any allergic reaction (itch, rash etc.) to any medicine.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•General dosage regimen: For treatment of tinea, cutaneous candidiasis, chromophytosis, apply once daily to cover the affected area.
For treatment of seborrheic dermatitis, apply twice a day to cover the affected area.
Strictly follow the instructions of your doctor/pharmacist in either case.
•Shake the bottle before use.
•Do not apply into the eyes.
•If you miss a dose, apply the missed dose as soon as possible. DO NOT use a double dose to make up for the missed dose.
•If you use too much of this medicine (more than ordered), check with your doctor/pharmacist. If any lotion gets into your eyes, immediately rinse with water or lukewarm water and check with your doctor/pharmacist.
•Do not stop using this medicine without the instructions of your doctor.
Precautions while taking this medicine
• Possible adverse reactions to this medicine
Common side effects are reported as below. If any of them occurs, check with your doctor/pharmacist: irritation, itching, contact dermatitis, erythema, vesicle.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
No pertinent entries.
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of children. Store away from direct sunlight, heat and humidity.
•Discard the remainder. Do not store them.
http://www.info.pmda.go.jp/go/pack/2655709Q1025_1_08/