苯妥英钠稀释剂DILANTIN(phenytoin sodium)
Dilantin（苯妥英钠）是一种抗癫痫药物，处方用于控制大发作癫痫发作和颞叶癫痫发作。 该药物还可用于预防和治疗神经外科手术（脑和脊髓手术）期间和之后发生的癫痫发作
DILANTIN Rx
Generic Name and Formulations:
Phenytoin sodium 30mg, 100mg; ext-rel caps.
Company:
Pfizer Inc
Indications for DILANTIN:
Tonic-clonic, psychomotor and neurosurgically induced seizures.

Adult:
Initially: 100mg 3 times daily. Increase weekly if needed; max 200mg 3 times daily. Once-a-day dosing only with ext-rel caps for patients controlled on 300mg daily.

Children:
Initially 5mg/kg per day in 2–3 equally divided doses. Increase weekly if needed. Usual maintenance: 4–8mg/kg per day; max 300mg daily.

Contraindications:
Concomitant delavirdine.

Warnings/Precautions:
Suicidal tendencies (monitor). Diabetes. Impaired liver function. Discontinue if acute hepatotoxicity occurs; do not restart. Adjust dose gradually. Discontinue if first sign of rash develops. Monitor serum levels when switching between sodium salt of phenytoin (caps) and free acid form (suspension, Infatabs). Use proper dental hygiene. Hormonal contraception. Monitor bone mineral density with chronic use. Porphyria. Elderly. Debilitated. Pregnancy (Cat.D). Nursing mothers: not recommended.

Interactions:
Potentiated by acute alcohol ingestion, amiodarone, antiepileptic agents (eg, ethosuximide, felbamate, oxcarbazepine, methsuximide, topiramate), azoles (eg, fluconazole, ketoconazole, itraconazole, miconazole, voriconazole), benzodiazepines (eg, chlordiazepoxide, diazepam), capecitabine, chloramphenicol, disulfiram, estrogens, fluorouracil, fluoxetine, fluvastatin, fluvoxamine, halothane, H2-blockers (eg, cimetidine), isoniazid, methylphenidate, omeprazole, phenothiazines, salicylates, sertraline, succinamides (eg, ethosuximide), sulfonamides, ticlopidine, tolbutamide, trazodone, warfarin. Antagonized by anticancer drugs (eg, bleomycin, carboplatin, cisplatin, doxorubicin, methotrexate), chronic alcohol ingestion, carbamazepine, diazepam, folic acid, fosamprenavir, nelfinavir, reserpine, rifampin, ritonavir, St. John’s wort, sucralfate, theophylline, vigabatrin. Antagonizes albendazole, HIV antivirals (eg, efavirenz, lopinavir/ritonavir, indinavir, nelfinavir, ritonavir, saquinavir), antiepileptic agents (eg, carbamazepine, felbamate, lamotrigine, topiramate, oxcarbazepine, quetiapine), atorvastatin, fluvastatin, simvastatin, chlorpropamide, clozapine, cyclosporine, digoxin, folic acid, methadone, mexiletine, nifedipine, nimodipine, nisoldipine, praziquantel, verapamil. Reduces efficacy of concomitant azoles, corticosteroids, doxycycline, estrogens, furosemide, irinotecan, oral contraceptives, paclitaxel, paroxetine, quinidine, rifampin, sertraline, teniposide, theophylline, vitamin D, warfarin. Concomitant fosamprenavir/ritonavir may potentiate amprenavir. Concomitant neuromuscular blockers (eg, pancuronium, vecuronium, rocuronium, cisatracurium); may need higher infusion rate. Variable effects with phenobarbital, valproic acid, sodium valproate. Absorption decreased by calcium, antacids.

See Also:
DILANTIN INFATABS

DILANTIN SUSPENSION

Pharmacological Class:
Hydantoin.

Adverse Reactions:
Nystagmus, ataxia, slurred speech, decreased coordination, somnolence, mental confusion, headaches, dizziness, cerebellar atrophy, nausea, vomiting, constipation, gingival hyperplasia, osteomalacia, blood dyscrasias, lymphadenopathy, hepatic disease, hyperglycemia, SLE, hypertrichosis; rare: rash (eg, Stevens-Johnson syndrome, toxic epidermal necrolysis), DRESS, multiorgan hypersensitivity.

Note:
To enroll in the North American Antiepileptic Drug Pregnancy Registry call (888) 233-2334.

Generic Availability:
YES

How Supplied:
Caps 30mg—100; 100mg—100, 1000; Tabs—100; Susp—8oz

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注：以下是美国上市产品，不同规格和不同价格，采购以咨询为准
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DILANTIN CAP 100MG 100  PHENYTOIN SODIUM EXTENDED     00071-0369-24   
DILANTIN CAP 100MG 1000  PHENYTOIN SODIUM EXTENDED     00071-0369-32
DILANTIN CAP 100MG UD 100  PHENYTOIN SODIUM EXTENDED     00071-0369-40  
DILANTIN CAP 30MG 100  PHENYTOIN SODIUM EXTENDED     00071-3740-66
DILANTIN INFATAB 50MG 100  PHENYTOIN     00071-0007-24
DILANTIN INFATAB 50MG UD 100  PHENYTOIN     00071-0007-40
DILANTIN-125 SUSP 8OZ  PHENYTOIN     00071-2214-20