马法兰(爱克兰、美法仑) 英文名: Melphalan,L-Sarcolysine, Alkeran,L-PAM ,CB3025。 生产厂家:葛兰素威康公司(GlaxoSmithKline) [化 学 名] L-3{对[双(2-氯乙基)胺基]苯基}丙氨酸。 [分 子 式] C13H18O2N2Cl2。 [性 状] 本品为白色至浅黄色粉末,难溶于水,对光、热及在潮湿情况下不稳定。 [药理作用] 本品为左旋体苯丙按酸氮芥,其抗癌效应按PAM为强,其作用机制与HN2相同,亦为细胞周期非特异性药物。 [体内过程] [临床应用] 口服:每日0.05~0.25mg/kg(2~10mg/m2),分次服用,共4~7日,本品与强的松合用,可能比单用更有效,联合用药通常间歇地进行,对治疗有效者延长疗程超过一年不会改变疗效。若无明显骨髓毒性,在4~6周内重复给药。 [不良反应] (1)骨髓抑制:为剂量限制性毒性,主要表现为白细胞、血小板减少及贫血,白细胞减少可在首次用药后的第2周至第3周出现;有时老年患者骨髓抑制可延续5~6周。 (2)胃肠道反应:大剂量一次用药可出现恶心、呕吐,小剂量持续给药则不明显。 (3)长期持续给药,偶可引起白血病、脱皮、皮炎、口炎及肺纤维化。 [禁 忌 证] (1)孕妇、哺乳妇禁用。 [注意事项] (1)每次用药前须检查血像,嗜中性白细胞低于2×109/L时应停药。 (2)应根据骨髓抑制程度调整剂量。 [病患教育] 对此药过敏,请不要服用此药品;避免饮酒;避免服用Aspirin(Tapal)或感冒药,需告知医师;接受疫苗注射前,需告知医师;容易感染,需避免到公共场所及预防感冒等;不要哺乳、怀孕,接受此药后可能会造成不孕;易有口腔发炎、疮及刺刺的感觉,口腔清洁需撤底。若要预防恶心,呕吐,可请医师开立止吐药处方,医师可以会为病人抽血检查血象。 我院荐有部份现货,购买时请以电话咨询价格为准! Alkeran(Melphalan)Alkeran Information
Alkeran belongs to the class of medicines used for treating cancer called antineoplastic. It lowers the growth and spread of the cancer cells in the body. Alkeran IndicationsThis product is used to treat cancer of the ovary, Breast Cancer and myeloma, a type of blood cancer. It can also be used as medication in some illness other than those mentioned before. Alkeran WarningsAlkeran belongs to the FDA category D that is known to cause defects to those unborn baby. Consult your doctor first before taking this medicine because it is not advisable to patients who are pregnant or is planning a pregnancy. Also, it is not good to take Alkeran when you are breast feeding a baby. Consult your doctor first before taking Alkeran if you have the following:
Alkeran can lower your immune system making you prone to infections so avoid contact with people who have colds, flu, and other contagious diseases during treatment with Alkeran. Alkeran Intake GuidelinesYou should take Alkeran exactly the same procedure or direction the doctor has prescribed. Ask your doctor, nurse, or pharmacist to explain them to you in case you do not understand the instructions. It is advised to take each oral dose with a large glass of water. Only qualified healthcare providers which is experienced in the use of cancer chemotherapeutic agents has the supervision to administer or to give injectable Alkeran. To monitor side effects and progress, your doctor might require you to have regular schedule of blood tests and other medical evaluations during the time of treatment with Alkeran. Alkeran DosageThe amount and frequency of treatment with Alkeran will be given by your doctor depending on the kind of cancer or disease to be treated and other factors. Alkeran OverdoseIf you overdose Alkeran, the symptoms is similar with its side effects only, sometimes it is more severe. If you have suspected any symptoms of overdose from this product, look for emergency medical attention or contact your healthcare provider immediately. Alkeran Missed DoseYou should contact your doctor in any cases of missed dose. Alkeran Side EffectsYou must contact your doctor or have an emergency medical treatment in case you experience the following serious side effects:
Consult your doctor if you experience the following less serious side effects:
Talk to your doctor about the risks and benefits of the medication because there are some reported cases that second cancers occur during and following the treatment with Alkeran. There are some side effects which were not mentioned so if there are any unusual or bothersome things that occur in you, tell your doctor about it. Alkeran Drug ReactionsInform your doctor first before taking Alkeran if you are using the following medicines:
In case that you are taking the medicines listed above, you might need some dosage adjustment or special monitoring during your treatment with Alkeran. It is dangerous to take ‘live’ vaccines during the treatment with Alkeran. Before taking other prescription or over-the-counter medicines like minerals, vitamins, and herbal products during the treatment of Alkeran, ask your doctor or pharmacist first because there are some other drugs which are not listed above that could affect Alkeran. |
序号 | 药品名称 | 通用名称 | 规格 | 单位 | 零售价(元) | 生产企业 |
7895 | 马法兰(爱克兰、美法仑) | 马法兰 | 2mg*25片 | 瓶 | 葛兰素威康公司(GlaxoSmithKline) |
*アルケラン錠2mg
薬効分類名
抗多発性骨髄腫剤