【中文品名】头孢克肟 【药效类别】抗生素>头孢菌素类 【通用药名】CEFIXIME 【别　　名】世福素, 氨噻肟烯头孢菌素, 克肟头孢菌素, 世伏素, Aerocef, Cefixoral, Cefspan, Cephoral, CL-284635, Denvar, Fixim, Necopen, Novacef, Oroken, Suprax, Tricef 【CA 名 称】 5-Thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-(2-amino-4-thiazolyl)[(carboxymethoxy)imino]acetyl]amino]-3-ethenyl-8-oxo-, (6R,7R)- 【CA登记号】[79350-37-1] 【结 构 式】 【分 子 式】C16H15N5O7S2 【分 子 量】453.444 【收录药典】 【开发单位】藤泽药品工业株式会社 (日本) 【首次上市】1987年，日本 【性　　状】 白色或淡黄色结晶性粉末。无臭或稍有特殊气味。易溶于甲醇、二甲基亚砜，难溶于乙醇，几乎不溶于水和乙醚。 mp240℃(dec)。其二钠盐(C16H13N5Na2O7S2)：mp>250℃。 【用　　途】 头孢烯类广谱抗生素。用于对本品敏感的链球菌、肺炎球菌、淋菌、大肠杆菌、克雷杆菌、沙雷菌、变形杆菌、嗜血流感杆菌等所引起的以下感染：气管炎、支气管 扩张、慢性呼吸道疾病二次感染、肺炎、肾盂肾炎、膀胱炎、淋病性尿道炎、胆囊炎(胆道炎、猩红热、中耳炎及副鼻腔炎。 【原产地英文商品名】Cefspan fine granules 50mg(セフスパン) 100g/bottle 【原产地英文药品名】Cefixime 【中文参考商品译名】世福素细粒剂50毫克(セフスパン) 100克/瓶 【中文参考药品译名】头孢克肟 【生产厂家中文参考译名】安斯泰来 【生产厂家英文名】Astellas 颗粒剂50毫克Sefusupan 安斯泰来制药公司 主成分水合物头孢克肟 淡橙色的细颗粒配方 在包装颗粒50毫克Sefusupan，50mg/1g，马克的安斯泰来 可以抑制抗菌活性，通过抑制细菌细胞壁的合成与这种药物作用效应的扩散。头孢菌素是抗生素用于治疗感染。 通常情况下，呼吸道感染，皮肤感染，耳鼻喉感染，是用于治疗尿路感染，包括感染范围广。   我喜欢下面，请告诉医生和药剂师在使用前。使用药物之前，瘙痒，过敏性反应，使皮疹就出来了。 怀孕或哺乳。 其他药物的使用（或互为因果的行为，或者它也可能减弱，请注意其他药物，包括非处方药使用）。   给药方案（这种药物的正确使用），一般1.5〜3mg/kg儿童[0.03〜0.06g/kg的活性成分（效价）一]通常采取每天两次。将调整根据治疗疾病或症状。如果严重或反应不足一6mg/kg 0.12g/kg [（效价）]通常采取每天两次。 50毫克的本药1g（效价）和包含的活性成分。请按照说明书上的剂量是针对。 补服的通知时，请喝一剂，尽快。如果时间差不多了，未来饮料通常是跳过一个，请采取补服未来定期每隔一小时。喝一次两次在任何一分钟。 如果您不小心喝了很多，请咨询您的医生或药剂师。 没有医生的监督，请停止服用自行选择是否采用中药。   之后，你可以以此为主要的副作用，皮疹，麻疹灰尘，红斑，瘙痒，发热，水肿药物（副作用）小心，腹泻，有报道，如胃部不适。如果你注意到这些症状，请咨询您的医生或药剂师。 如症状：在极少数情况下，[]可能是括号内表示的副作用症状。 如果发生这种情况，停止使用，请索取立即就医。 浆状，冷汗，头晕[休克，过敏症状] 发烧，水泡，红疹[史蒂文斯 - 约翰逊综合征，中毒性表皮坏死松解症] 易发生出血，全身性浊音，发热[粒细胞缺乏症，溶血性贫血，血小板减少症] 尿量减少，肿胀，全身性浊音[急性肾功能衰竭] 发烧，咳嗽，从呼吸窘迫[间质性肺炎综合征，PIE] 这里没有列出的其他方面的影响可能会发生。如果你不担心任何上述症状，请咨询您的医生或药剂师。   存储和其他婴儿出在阳光直射，高温儿童接触，请远离潮湿了。 如果剩下的药，请丢弃 ------------------------------------------------------------------------------------------------------------------------------------------ セフスパン細粒50mg アステラス製薬株式会社 主成分 セフィキシム 剤形 淡いだいだい色の細粒剤 シート記載 セフスパン細粒50mg、50mg/1g、社マーク+astellas Cefspan - General Information: Cefspan, an antibiotic, is a third-generation cephalosporin like ceftriaxone and cefotaxime. Cefspan is highly stable in the presence of beta-lactamase enzymes. As a result, many organisms resistant to penicillins and some cephalosporins due to the presence of beta-lactamases, may be susceptible to cefixime. The antibacterial effect of cefixime results from inhibition of mucopeptide synthesis in the bacterial cell wall. Pharmacology: Cefspan, an antibiotic, is a third-generation cephalosporin like ceftriaxone and cefotaxime. Cefspan is highly stable in the presence of beta-lactamase enzymes. As a result, many organisms resistant to penicillins and some cephalosporins due to the presence of beta-lactamases, may be susceptible to cefixime. The antibacterial effect of cefixime results from inhibition of mucopeptide synthesis in the bacterial cell wall. Cefspan for patients Cefixime is a cephalosporin antibiotic used to treat bacterial infections. Take at regular intervals and complete the entire course of therapy. Do not take this medication if you are allergic to any type of penicillin or cephalosporin. Notify your physician if you are pregnant or nursing. This antibiotic may decrease the effectiveness of birth control pills; use another form of birth control while taking this medication. Shake the suspension well before each use and store it in the refrigerator. May cause nausea, vomiting or diarrhea; notify your physician if these occur. Take with food or milk to avoid stomach upset. Cefixime may cause a false-positive reaction for nonspecific urine glucose tests in patients with diabetes. This medication does not interfere with enzyme-based urine glucose tests. Cefspan Interactions Carbamazepine: Elevated carbamazepine levels have been reported in postmarketing experience when SUPRAX is administered concomitantly. Drug monitoring may be of assistance in detecting alterations in carbamazepine plasma concentrations. Warfarin and Anticoagulants: Increased prothrombin time, with or without clinical bleeding, has been reported when cefixime is administered concomitantly. Drug/Laboratory Test Interactions A false-positive reaction for ketones in the urine may occur with tests using nitroprusside but not with those using nitroferricyanide. The administration of SUPRAX may result in a false-positive reaction for glucose in the urine using ClinitestÒ**, Benedictís solution, or Fehlingís solution. It is recommended that glucose tests based on enzymatic glucose oxidase reactions (such as Clinistix®** or Tes-TapeÒ**) be used. A false-positive direct Coombs test has been reported during treatment with other cephalosporin antibiotics; therefore, it should be recognized that a positive Coombs test may be due to the drug. Cefspan Contraindications SUPRAXÒ is contraindicated in patients with known allergy to the cephalosporin group of antibiotics. Additional information about Cefspan Cefspan Indication: For use in the treatment of the following infections when caused by susceptible strains of the designated microorganisms: (1) uncomplicated urinary tract infections caused by Escherichia coli and Proteus mirabilis, (2) otitis media caused by Haemophilus influenzae (beta-lactamase positive and negative strains), Moraxella catarrhalis (most of which are beta-lactamase positive), and S. pyogenes, (3) pharyngitis and tonsillitis caused by S. pyogenes, (4) acute bronchitis and acute exacerbations of chronic bronchitis caused by Streptococcus pneumoniae and Haemophilus influenzae (beta-lactamase positive and negative strains), and (5) uncomplicated gonorrhea (cervical/urethral) caused by Neisseria gonorrhoeae (penicillinase- and non-penicillinase-producing strains). Mechanism Of Action: Like all beta-lactam antibiotics, cefixime binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefixime interferes with an autolysin inhibitor. Drug Interactions: Probenecid Probenecid increases the antibiotic's level Food Interactions: Preferably on an empty stomach, rate of absorption is decreased but extenet of absorption remains the same: not really problematic. Generic Name: Cefixime Synonyms: Cefixima [Spanish]; Cefixime Anhydrous; Cefiximum [Latin]; Cefixim Drug Category: Anti-Bacterial Agents; Cephalosporins Drug Type: Small Molecule; Approved Other Brand Names containing Cefixime: CFIX; Cefixoral; Cefspan; Cephoral; Oroken; Suprax; Unixime; Absorption: About 40%-50% absorbed orally whether administered with or without food, however, time to maximal absorption is increased approximately 0.8 hours when administered with food. Toxicity (Overdose): Symptoms of overdose include blood in the urine, diarrhea, nausea, upper abdominal pain, and vomiting. Protein Binding: 65% (concentration independent) Biotransformation: Hepatic. Approximately 50% of the absorbed dose is excreted unchanged in the urine in 24 hours. Half Life: 3-4 hours (may range up to 9 hours). In severe renal impairment (5 to 20 mL/min creatinine clearance), the half-life increased to an average of 11.5 hours. Dosage Forms of Cefspan: Tablet Oral Powder, for suspension Oral Chemical IUPAC Name: (6R,7R)-7-[[2-(2-amino-1,3-thiazol-4-yl)-2-(carboxymethyloxyimino)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical Formula: C16H15N5O7S2 Organisms Affected: Enteric bacteria and other eubacteria