英文药名: Suprax(cefixime tablets)

中文药名: 头孢克肟片,世福素

品牌药生产厂家: Aventis

药品名称

【通用名称】头孢克肟片
【英文名称】Cefixime
【成份／规格】头孢克肟。头孢克肟悬浮液100mg/5ml。头孢克肟片 50mg;100mg;200mg;400mg。
药理毒理

对革兰氏阳性菌和革兰氏阴性菌均有较广泛的抗菌作用，特别是对革兰氏阳性菌中的链球菌属、肺炎球菌、革兰氏阴性菌中的淋球菌、伯雷汉氏菌属、大肠杆菌、沙雷氏杆菌属、克雷白氏菌属、变形杆菌属、流感杆菌等较其它口服头孢类有较强的抗菌能力，其作用方式为杀菌。 由于本品对各种细菌所产生的β-内酰胺酶极其稳定，因而对产生β-内酰胺酶的细菌也具有优异的抗菌力。 本品的作用机制主要是阻止细菌细胞壁的合成。
适应症

广谱抗菌素。对链球菌属、肺炎球菌、淋球菌、伯雷汉氏菌属、大肠杆菌、沙雷氏杆菌属、克雷白氏杆菌属、变形杆菌属、流感杆菌所引起的感染症有效。主要用于治疗支气管炎、支气管扩张合并感染、慢性呼吸道疾患继发感染、肺炎、肾盂肾炎、膀胱炎、淋菌性尿道炎、胆囊炎、胆管炎、猩红热、中耳炎、副鼻窦炎。
用法用量

口服。成人和体重30公斤以上的儿童一次50～100mg，一日2次。重症可增加到一次0.2g，一日2次。
任何疑问，请遵医嘱！
不良反应

主要为腹泻、粪便异常、头疼、恶心、腹痛、皮疹等，极少数患者GPT、GOT升高。
禁忌

对本品或头孢菌素类抗菌素有过敏史者禁用。
注意事项

对青霉素过敏者、过敏体质的患者、高度肾功能损害的患者、对不能很好进食或非经口摄取营养者、高龄者、恶液质等患者、孕妇、新生儿慎用。

Suprax is a broad-spectrum antibiotic used to treat infections of respiratory and urinary systems. Suprax is a cephalosporin antibiotic which bactericidal effect made it useful for treatment of infectious diseases such as pharyngitis, tonsillitis, sinusitis, acute and chronic bronchitis, chronic obstructive pulmonary disease, moderate otitis, non-severe infections of urogenital tract, gonococcal infection of the urethra and cervix, gonorrhea. It is a broad-spectrum antibiotic active against different aerobic and anaerobic gram positive and gram negative organisms including Pseudomonas aeruginosa. Suprax is resistant to beta-lactamases. It is especially active against different streptococcus such as: S. pneumoniae, S. pyogenes, S. agalactiae, microorganisms of genus Haemophilus such as H. influenzae, H. parainfluenzae and others: Moraxella catarrhalis, Escherichia coli, Proteus mirabilis, Proteus vulgaris, Neisseria gonorrhoeae, Klebsiella pneumoniae, Klebsiella oxytoca, Pasteurella sp., Providencia, Salmonella, and others. Dosage and directions Suprax should be taken with or without food with a big glass of water through equal time periods if it is prescribed as several daily intakes.

Precautions:
Before to take Suprax inform your doctor if you have had allergic reactions to penicillins or other cephalosporin antibiotics, stomach or intestinal disease such as colitis in history. Patients with kidney disorders require correction of Suprax dosage. Avoid repeated treatment with this medication as it may result in a secondary infection.
 
Contraindications:
Hypersensitivity to Suprax and penicillins, babies younger than 6 month, pregnancy, breastfeeding. Certain cautiousness should be exercised in adult patients, ones with kidney failure, colitis in history.
 
Side effect:
Severe allergic reactions as rash, hives, itching, difficulty breathing, swelling of the mouth and face,may occur. In case of bloody stools, decreased urination, fever, red, swollen, blistered, or peeling skin, seizures, diarrhea, nausea or vomiting, abdominal pain, unusual bruising or bleeding, vaginal itching, white spots in the mouth, jaundice notify your doctor about your condition as you may need immediate medical help.
 
Drug interaction:
Probenecid (Benemid) may increase the blood concentration of Suprax by decreasing excretion of Suprax by the kidney. Co-administratyion of Suprax and aminoglycosides tobramycin (Tobradex) results in additive bacterial killing effects but also may increase damage to the kidney. Exenatide (Byetta) may delay or reduce the absorption of Suprax. Cephalosporins should be administered one hour before exenatide. Concomitant administration of Suprax and Carbamazepine increases concentration of the latter in blood serum. Suprax may cause a false positive urine ketone and glucose tests.
 
Missed dose:
If you missed a dose take it as soon as you remember. If you take Suprax once daily take the missed dose as soon as you remember. Next dose should be taken in 10-12 hours. If it was prescribed to you to take this medication twice or thrice daily take the missed dose and then the next one in 5-6 or 2-4 hours accordingly. Never double dose this medication.
 
Overdose:
In case of serious and persistent symptoms of allergy or blood in the urine, diarrhea, nausea, upper abdominal pain, vomiting consult your doctor about medical attention.

Cefixime ( SUPRAX, Cefixime 200mg x 2 tablets) treatment of gonorrhea