Flomax一般治疗前列腺增大（良性前列腺增生症;良性前列腺增生症） 。也可用于医生确诊的其他病症。 Flomax是一个α -受体阻滞剂。它的工作原理是放松前列腺癌和膀胱癌的肌肉，这有助于改善尿流，减少前列腺增生的症状。

Tamsulosin (rINN) is an α1a-selective alpha blocker used in the symptomatic treatment of benign prostatic hyperplasia (BPH). Tamsulosin was developed by Yamanouchi Pharmaceuticals (now part of Astellas Pharma) and is marketed by various companies under licence, including Boehringer-Ingelheim and CSL. Tamsulosin hydrochloride extended-release capsules are marketed under the trade names Flomax, Flomaxtra and Urimax, though generic non-modified release capsules are still approved and marketed in many countries, such as Canada. The U.S. patent for Flomax is set to expire October 2009.
Mechanism
Main article: Alpha blocker
Tamsulosin is a selective α1 receptor antagonist that has preferential selectivity for the α1A receptor in the prostate versus the α1B receptor in the blood vessels.
Clinical uses
Tamsulosin is primarily used for benign prostatic hyperplasia, but is sometimes used for the passage of kidney stones by the same mechanism of smooth muscle relaxation via alpha antagonism.
Adverse effects
Two ADRs (Adverse Drug Reactions) have been reported:
Immunologic: It contains a sulfa moiety, thus causing typical reactions to sulfa drugs.
Ophthalmologic: Patients taking tamsulosin are prone to a complication known as floppy iris syndrome during cataract surgery. Adverse outcomes of the surgery are greatly reduced by the surgeon's prior knowledge of the patient's history with this drug, and thus having the option of alternative techniques.
Tamsulosin has also affected the sexual function in men. Tamsulosin can cause males to experience retrograde ejaculation. In males, retrograde ejaculation occurs when the fluid to be ejaculated, which would normally exit the body via the urethra, is redirected to the urinary bladder. Normally, the sphincter of the bladder contracts and the ejaculate goes to the urethra, the area of least pressure. In retrograde ejaculation, this sphincter does not function properly. Occasionally, tamsulosin can cause a drop in blood pressure, rarely resulting in dizziness or fainting. Other reported side effects include headache, dizziness, nasal congestion, and palpitations.
Clinical comparison
Although prostate specific, it does not have the prostate apoptotic effects of other alpha-blockers such as doxazosin and terazosin.
Use in Combination Therapy
The results of the CombAT (Combination of Avodart and Tamsulosin) trial have recently demonstrated that treatment with the combination of dutasteride and tamsulosin provides superior symptom benefits compared with either monotherapy.
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原产地英文商品名:
Flomax 0.4 mg/capusle 30 capusles/bottle
原产地英文药品名:
Tamsulosin
中文参考商品译名:
Flomax 0.4毫克/粒 30粒/瓶
中文参考药品译名:
坦索罗新
生产厂家中文参考译名:
加拿大勃林格殷格翰公司
生产厂家英文名:
Boehringer Ingelheim Pharmaceuticals, Inc.