英文药名: Naprelan(Naproxen Sodium Tablets)

中文药名: 萘普生钠片

药品名称

中文通用名称: 萘普生
英文通用名称: Naproxen
其 它 名 称: 消痛灵, 消炎宁, 甲氧萘丙酸, Naprosyn, Naxen, Equiproxen, Bayley, 帕诺丁, 劳斯叮, Neproxen, 适洛特, 金康普力, 步生, Methoxypropiocin, 萘普生缓释片, 萘普生胶囊, 萘普生片, 萘普生栓, 萘普生注射液, 萘普生颗粒, Ipdas, Naprelan, Napren-E, Naprooxen, Nycopren, 芬斯呵, 希普生, 澳普利, Naproxen Suppositoris, Naproxen Dispersible Tablets, Naproxen Injection, Naproxen Suppositories, Naproxen Sustained Release Tablets, Napton,Napton SR, 那普洛, 萘普生肠溶微丸胶囊, 萘普生分散片, 萘普生缓释胶囊, Naproxen Capsules, Naproxen Granules, Naproxen Powder, Naproxen SR Tablets, Naproxen Sustained Release Capsules, Naproxen Tablets, 芬斯叮, 惠可, 萘普生散, Naproxen Enteric-coated Pellets Capsules
产 品 分 类: 西药\镇痛药\解热镇痛抗炎药\丙酸类
规格

萘普生片 125mg, 250mg, 375mg, 500mg。萘普生肠溶片 250mg, 375mg, 500mg。萘普生缓释片 750mg。
适应症

1.用于治疗风湿性关节炎和类风湿关节炎、骨性关节炎、强直性脊柱炎、幼年型关节炎(Juvenilearthritis)、肌腱炎、腱滑膜炎、滑囊炎及急性痛风性关节炎。对关节炎的疼痛、肿胀及活动受限均有缓解作用。
2.用于缓解各种轻、中度疼痛，如手术后疼痛、牙痛、神经痛、原发性痛经及头痛等。
3.也用于关节及肌肉扭伤、挫伤和纤维组织炎的消炎及镇痛。
4.栓剂还可用于宫腔手术和检查时的镇痛，如早期妊娠的人工流产手术、诊断性刮宫术、清宫术、节育环安取术及子宫内镜检查手术。
用法用量

成人
•常规剂量
•口服给药
1.普通口服制剂：
(1)抗风湿：一次0.25-0.5g，早晚各1次；或早晨服0.25g，晚上服0.5g。
(2)镇痛：首剂0.5g，以后必要时一次0.25g，每6-8小时1次。
(3)痛风性关节炎急性发作：首剂0.75g，以后一次0.25g，每8小时1次，直到急性发作停止。
(4)痛经：首剂0.5g，以后必要时一次0.25g，每6-8小时1次。
2.缓释口服制剂：一次0.5g，一日1次。
•直肠给药
1.用于关节炎及镇痛等：一次0.125-0.25g，一日0.5g。
2.用于宫腔手术和检查：0.4g(1枚)置入肛门内，15分钟后即可手术。
•肌内注射一次0.1-0.2g，一日1次。
•肾功能不全时剂量
应减少剂量。
•肝功能不全时剂量
肝硬化患者服用本药时剂量应减半。
•老年人剂量
用量应酌减。
儿童
•常规剂量
•口服给药抗风湿：一日0.01g/kg，分2次服。
任何疑问，请遵医嘱！
给药说明

1.肾功能不全患者用药期间应监测血清肌酸酐和(或)肌酐清除率；某些患者特别是肾血流受损者(如细胞外脱水、钠盐限制、充血性心力衰竭、肝功能不全及先天性肾病)，治疗前及治疗期间应监测肾功能。在进行肾功能测试前，应暂停使用本药40小时
2.嗜酒引起的慢性肝病及其它肝硬化患者使用本药高剂量时应谨慎。因血浆中的药物总浓度会下降，但血浆中未结合(游离)药物的浓度会升高。
3.胃肠道疾病患者应在严密医疗监护下服用本药。
4.本药缓释制剂应整片(粒)吞服，不得咀嚼。
5.本药与皮质激素合用较安全，但两者合用的疗效并不比单用皮质激素好。
6.由于本药血浆蛋白结合率较高，对同时服用乙内酰脲类(Hydantoins)药物的患者须密切监测，必要时调整用药剂量。
7.抗风湿治疗长期给药时，须根据患者对药物的反应来调整剂量，通常应用最低有效量。
8.使用本药栓剂以镇痛不得超过5日。
9.用药期间，如患者出现胃肠出血、肝肾功能异常、过敏反应、水潴留、血液异常、视物模糊、听力下降以及精神异常等情况时，应立即停药，并作相应处理；其它不良反应持续存在时也应注意。
10.用药过量中毒时应予以紧急处理，包括催吐或洗胃、口服活性炭及抗酸药、给予对症及支持治疗及合理使用利尿药。
不良反应

1.发生率为3%-9%的不良反应有：皮肤瘙痒、呼吸短促、呼吸困难、哮喘、耳鸣、下肢水肿、消化不良、恶心及呕吐、胃烧灼感、胃痛或其它胃部不适、便秘、头晕、头痛及嗜睡等。
2.发生率为1%-3%的不良反应有：视物模糊或视觉障碍、听力减退、腹泻、口腔刺激或痛感、心悸及多汗、胃肠道出血、肾脏损害(过敏性肾炎、肾乳头坏死及肾衰竭等)、荨麻疹、血管性水肿、过敏性皮疹、抑郁、肌无力、出血、粒细胞减少及肝功能损害等。
3.长期服用本药口服制剂，患者耐受良好。
注意事项

1.交叉过敏对阿司匹林或其它非甾体类抗炎药过敏者，对本药也过敏。
2.禁忌症
(1)对本药或同类药过敏者。
(2)曾因使用阿司匹林或其它非甾体类抗炎药引起哮喘、鼻炎及鼻息肉综合征者的患者。
(3)消化性溃疡活动期或有溃疡合并出血和穿孔史者。
(4)哺乳妇女。
(5)2岁以下儿童。
3.慎用
(1)有凝血机制或血小板功能障碍者。
(2)哮喘患者。
(3)心功能不全或高血压患者。
(4)肝功能不全者。
(5)肾功能不全者(肌酐清除率低于20ml/min的患者不应长期服用本药)。
(6)有消化性溃疡史者。
(7)胃肠道疾病患者。
4.药物对儿童的影响2岁以下儿童使用本药的安全性及疗效尚未确立，2岁以下儿童禁用。
5.药物对老人的影响本药在老人体内血浆半衰期长，老年人应慎用。
6.药物对妊娠的影响本药能延缓动物的分娩时间，同时也能影响胎仔的心血管系统(动脉导管的闭合)。对胎儿的影响尚无充分研究。妊娠期(尤其是妊娠早期和晚期)，使用本药应权衡利弊。美国药品和食品管理局(FDA)对本药的妊娠安全性分级为B级(妊娠早、中期)和D级(妊娠晚期)。
7.药物对哺乳的影响本药在乳汁中的浓度相当于血药浓度的1%。哺乳妇女禁用。
8.药物对检验值或诊断的影响本药可影响尿5-羟吲哚醋酸(5-HIAA)及尿17-酮的测定值。
9.用药前后及用药时应当检查或监测长期用药应定期进行肝功能、肾功能、血常规及眼科检查。

Brand names: Aflaxen™, Aleve®, Anaprox®, Anaprox® DS, Mediproxen®, Naprelan®, Naprelan® 375, Naprelan® 500, Naprosyn®, Wal-Proxen

Naproxen Gastro-resistant tablet

What is this medicine?

NAPROXEN (na PROX en) is a non-steroidal anti-inflammatory drug (NSAID). It is used to reduce swelling and to treat pain. This medicine may be used for dental pain, headache, or painful monthly periods. It is also used for painful joint and muscular problems such as arthritis, tendinitis, bursitis, and gout.
 
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
• asthma
• cigarette smoker
• drink more than 3 alcohol containing drinks a day
• heart disease or circulation problems such as heart failure or leg edema (fluid retention)
• high blood pressure
• kidney disease
• liver disease
• stomach bleeding or ulcers
• an unusual or allergic reaction to naproxen, aspirin, other NSAIDs, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Do not cut, crush or chew this medicine. Take it with food if your stomach gets upset. Try to not lie down for at least 10 minutes after you take it. Take your medicine at regular intervals. Do not take your medicine more often than directed. Long-term, continuous use may increase the risk of heart attack or stroke.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.

What may interact with this medicine?

• alcohol
• antacids
• aspirin
• cidofovir
• diuretics
• lithium
• medicines for stomach, or intestine problems, like acid reflux or GERD
• methotrexate
• other drugs for inflammation like ketorolac or prednisone
• pemetrexed
• probenecid
• sucralfate
• warfarin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Tell your doctor or health care professional if your pain does not get better. Talk to your doctor before taking another medicine for pain. Do not treat yourself.
 
This medicine does not prevent heart attack or stroke. In fact, this medicine may increase the chance of a heart attack or stroke. The chance may increase with longer use of this medicine and in people who have heart disease. If you take aspirin to prevent heart attack or stroke, talk with your doctor or health care professional.
 
Do not take other medicines that contain aspirin, ibuprofen, or naproxen with this medicine. Side effects such as stomach upset, nausea, or ulcers may be more likely to occur. Many medicines available without a prescription should not be taken with this medicine.
 
This medicine can cause ulcers and bleeding in the stomach and intestines at any time during treatment. Do not smoke cigarettes or drink alcohol. These increase irritation to your stomach and can make it more susceptible to damage from this medicine. Ulcers and bleeding can happen without warning symptoms and can cause death.
 
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.
 
This medicine can cause you to bleed more easily. Try to avoid damage to your teeth and gums when you brush or floss your teeth.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
• black or bloody stools, blood in the urine or vomit
• blurred vision
• chest pain
• difficulty breathing or wheezing
• nausea or vomiting
• skin rash, skin redness, blistering or peeling skin, hives, or itching
• slurred speech or weakness on one side of the body
• swelling of eyelids, throat, lips
• unexplained weight gain or swelling
• unusually weak or tired
• yellowing of eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
• constipation
• headache
• heartburn

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date