部份中文净透明质酸钠处方资料（仅供参考）
类别名称
关节功能改善剂
欧文商標名
ADANT INTRA-ARTICULAR INJECTION 25mg
ADANT DISPO INTRA-ARTICULAR INJECTION 25mg
通用名称
纯净透明质酸钠
通用名称
（欧洲名）纯化透明质酸钠（Purified Sodium Hyaluronate）
分子式
（C14H20NNaO11）N
分子量
平均分子量 500000-1200000
性状
钠纯化透明质酸是一团白色粉末，颗粒或纤维。
此产品是微溶于水，并在乙醇（99.5）几乎不溶。
本产品是吸湿。
構造式

操作注意事项
稳定性试验
包装产品的长期保存试验使用（25℃，60％，42个月相对湿度）的结果，Adanto关节注25毫克，已经证实，它是在市场分配一个正常稳定三年。
药效药理
覆盖和保护关节软骨表面的作用，软骨组织的变性变化的抑制效果，关节活动度改善挛缩关节的作用，并且具有关节疼痛的抑制作用。
对关节软骨的效果
正常兔膝关节腔内给药，摄取到软骨表面进行了观察。此外，在膝盖软骨（体外），分布扩散从软骨表面随着时间的推移，以所有层的人的骨关节炎，这种软骨中的分布是与蛋白多糖的损失地点一致。
抑制了牛关节软骨细胞的蛋白聚糖的释放（体外）。
在膝骨关节炎模型和固定膝关节挛缩模型使用兔，由关节腔给药，它抑制软骨的退变。
关节活动度改善作用
使用兔子固定膝关节挛缩模型，它是由关节腔内给药，以提高运动范围。
疼痛抑制作用
尿酸盐晶体诱发的膝关节疼痛与狗，观察到抑制效果
适应症
膝关节骨性关节炎，肩周炎
膝关节疼痛的类风湿关节炎（以下至（前提是满足4所有标准））
任何系统性膝关节疼痛即使疾病是不能够在治疗以控制与抗风湿药等。
全身性的炎症症状是小于或等于10毫克/分升的CRP值
轻度膝关节症状中度
LarsenX行膝关节从一级到三级分类
用法用量
膝关节骨性关节炎，肩周炎
成人一次，每周5 Kaihiza关节腔内或肩关节连续每安瓿内和症状给予（肩关节间隙，肩峰下滑囊或肱二头肌长Atamakenkensaya）以增加或减少的剂量的数目为适当。
类风湿关节炎膝关节疼痛
给予连续五年Kaihiza关节腔每周一次的成人2.5毫升。
任何疑问，请遵医嘱
包装规格
注射液
1％ 2.5毫升*10安瓿

注射器
1％ 2.5毫升（套件产品）10注射器

制造厂商
明治制果制药社
ADANT INTRA-ARTICULAR INJECTION 25mg（アダント関節注25mg）
Brand name : ADANT INTRA-ARTICULAR INJECTION 25mg
　Active ingredient: Purified sodium hyaluronate
　Dosage form: injection
　Print on wrapping:
------------------------------------
ADANT DISPO INTRA-ARTICULAR INJECTION 25mg（アダントディスポ関節注25mg）
Brand name : ADANT DISPO INTRA-ARTICULAR INJECTION 25mg
　Active ingredient: Purified sodium hyaluronate
　Dosage form: injection
　Print on wrapping:
------------------------------------
Effects of this medicine
This medicine suppresses pain and inflammation of knee and shoulder joint, and improves the movements.
It is usually used to treat osteoarthritis of the knee, frozen shoulder and knee pain of rheumatoid arthritis.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have or have previously experienced liver disorder.
If you have skin disease on injection site.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•Osteoarthritis of the knee and frozen shoulder: In general, inject into a joint cavity of knee or a joint of shoulder once a week for five consecutive times.
Rheumatoid arthritis: In general, inject into a joint cavity of knee once a week for five consecutive times.
•The treatment period with this medicine depends on your symptoms or response to this medicine.
Precautions while taking this medicine
• Possible adverse reactions to this medicine
The most commonly reported adverse reactions include injection site pain, injection site swelling, edema of knee on injection site, rash such as hives, itching, edema (edema of face/eyelid, etc) and facial redness. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•dizziness, facial pallor, loss of consciousness [shock]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep at rest if you have joint pain after injection.
•Keep the injection site clean as much as possible.
Meiji Seika Pharma Co., Ltd.Injection
Published: 2/2015
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
http://www.kegg.jp/medicus-bin/japic_med?japic_code=00055086
http://www.kegg.jp/medicus-bin/japic_med_product?id=00055062-001