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富马酸福莫特罗胶囊FORADIL(FORMOTEROL FUMARATE)

2012-09-23 17:14:03  作者:新特药房  来源:中国新特药网天津分站  浏览次数:224  文字大小:【】【】【
简介: 部分中文富马酸福莫特罗处方资料(仅供参考) 中文名称: 富马酸福莫特罗。 中文别名: N-[2-羟基-5[(RS)-1-羟基-2-[(RS)-2-(4-甲氧基苯基)-1-甲基乙基胺]乙基]苯基]甲酰胺半富马酸。 英文名称: ...

 部分中文富马酸福莫特罗处方资料(仅供参考)

中文名称: 富马酸福莫特罗。

中文别名: N-[2-羟基-5[(RS)-1-羟基-2-[(RS)-2-(4-甲氧基苯基)-1-甲基乙基胺]乙基]苯基]甲酰胺半富马酸。

英文名称: Formoterol Fumarate

英文别名: Formoterol fumarate [USAN] ;n-(2-hydroxy-5-(1-hydroxy-2-((2-(4-methoxyphenyl)-1-methylethyl)amin;o)ethyl)phenyl)-,(e)-2-butenedioate(2:1)(salt)

产品用途: 用作支气管扩张药,长效β2受体选择性激动剂,用于治疗支气管哮喘

研究显示对COPD患者Foradil(R) Aerolizer(TM)比茶碱更有效
    4月份的CHEST发表的一项新的研究显示,有症状的慢性阻塞性肺疾病的患者,长期服用Foradil® Aerolizer(TM)(福莫特罗富马酸盐吸入粉剂),要比口服缓释茶碱的效果更好,并且患者的耐受性也更好。CHEST是美国胸科医生学会的官方杂志。  
    亚利桑那大学的临床医学教授Bernard Levine博士是该试验的研究者和文章的作者之一。他指出,“我们能够为慢性阻塞性肺疾病患者做的最重要的事情之一,就是控制他们的症状,加强对疾病的日常管理。对该病的治疗原则建议使用支气管扩张剂作为一线药物,因此医生和患者均应知道药物之间的区别。这次的研究证实,长期坚持每日服用两次Foradil Aerolizer对控制慢性阻塞性肺疾病患者的症状的效果。同时还表明Foradil Aerolizer的疗效要优于茶碱。”   
    在改善肺功能方面,每日服用Foradil Aerolizer两次,每次12 mcg,其疗效要明显的优于茶碱。两者比较,P值小于或等于0.026。与安慰剂相比,使用两种剂量的Foradil Aerolizer或茶碱,经过12个月的治疗,均能显著的改善肺功能。其P值均小于0.001。其中Foradil Aerolizer的剂量为12mcg 或 24mcg,每日两次;茶碱的剂量为200 或300 mg,每日两次。Foradil Aerolizer的推荐剂量为12mcg,每日两次。  
    同时研究还发现,两种剂量的Foradil Aerolizer可以改善以下的一些评价疗效的重要指标,而茶碱则没有这些效果。服用Foradil Aerolizer的患者所经历的症状恶化的时间要短。与安慰剂或茶碱相比,P值小于或等于0.035。在12个月的治疗期间,服用Foradil Aerolizer还能够减少患者需要急救的次数。与安慰剂相比,P值小于或等于0.003。这是第一次公布有关Foradil Aerolizer的治疗效果要优于缓释茶碱的临床资料。

Foradil Aerolizer
Generic Name: Formoterol

What is Foradil Aerolizer?
Foradil Aerolizer helps control asthma in people who need regular treatment with short-acting inhalers. Foradil Aerolizer is also used to relieve tightening of the airways in people with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. Taken as needed, Foradil Aerolizer can also be used to prevent exercise-induced bronchospasm (EIB), which is tightening of the airways.

What is the most important information I should know about Foradil Aerolizer?
Foradil Aerolizer is used to prevent asthma attacks. Do not use it to relieve acute asthma symptoms. Your doctor will prescribe a short-acting inhaler, such as albuterol, to use for acute asthma attacks. Do not use Foradil as your only asthma medicine.

Foradil Aerolizer may increase the risk of asthma-related death. It should only be used as additional therapy if you are not adequately controlled on other asthma medications or if your disease is severe enough to require treatment with two medications.

You should never swallow Foradil capsules. Foradil capsules are only to be used with the inhaler that comes with Foradil Aerolizer. Never place a capsule in the mouthpiece of the inhaler.

Foradil Aerolizer should not be used as a substitute for oral or inhaled corticosteroids.

Call your doctor if your breathing problems worsen over time while using Foradil; you may need different treatment.

Who should not take Foradil Aerolizer?
Do not take Foradil Aerolizer to treat your asthma without a long-term asthma control medicine, such as an inhaled corticosteroid.

Do not take Foradil Aerolizer if you are sensitive to any component of the medication, including lactose (milk sugar) or milk protein.

What should I tell my doctor before I take the first dose of Foradil Aerolizer?
Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Foradil. Also, talk to your doctor about your complete medical history, especially if your asthma is significantly worsening, or if you have high blood pressure, heart disease, an abnormal heart rhythm, a seizure disorder, thyroid disease, diabetes, kidney or liver disease, are pregnant or planning to become pregnant, or are breastfeeding.

What is the usual dosage?
The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

Asthma
Adults and children ≥5 years: For the long-term control of asthma, the recommended dosage is one capsule every 12 hours. Do not use more than two capsules per day.

Prevention of Exercise-Induced Asthma
Adults and children ≥5 years: The recommended dosage is one capsule at least 15 minutes before exercise. If a second dose is needed the same day, take it at least 12 hours after the first dose. Do not use more than two capsules per day. If you are already taking Foradil Aerolizer on a regular, twice-daily basis, do not take an extra dose before exercise.

Chronic Obstructive Pulmonary Disease
Adults: The usual dosage is one capsule every 12 hours. Do not use more than two capsules a day. If your usual dosage does not provide relief, check with your doctor. Other treatments may have to be added to your regimen.

How should I take Foradil Aerolizer?
Foradil capsules are intended for use only with the Aerolizer inhaler. They should not be swallowed.

Leave the capsules in the blister pack until you need them. Always throw out the Aerolizer by the "Use by" date.

To use the system, place a capsule in the well of the Aerolizer, then press and release the buttons on the side of the device. This will pierce the capsule. The medication is released into the airways when you breathe in rapidly and deeply through the mouthpiece. Detailed instructions are supplied with your prescription. If you have any questions, ask your doctor or pharmacist.

On rare occasions, the capsule may break into small pieces that can reach the throat or mouth during inhalation. A screen built into the inhaler should prevent any capsule pieces from being inhaled. To reduce the chance of the capsules breaking, store them in a dry place and keep them in their blister pack until just before use. Pierce the capsule only once.

Be sure your hands are dry before handling the capsules and be careful to keep the Aerolizer dry. Do not wash any part of the device. Throw away the Aerolizer when your prescription is finished and replace it with the new one provided with each refill.

After use, open the inhaler and remove and throw away the empty capsule.

What should I avoid while taking Foradil Aerolizer?
Do not use Foradil Aerolizer with a spacer and never exhale into the Aerolizer device.

Never take the Aerolizer inhaler apart.

Never place a Foradil capsule directly into the mouthpiece of the inhaler. Never leave a used capsule in the inhaler chamber.

Always use the new inhaler that comes with your next refill. Do not use the inhaler from your last refill.

Avoid exposing Foradil capsules to moisture.

Avoid situations that may trigger an asthma attack.

Do not use Foradil Aerolizer more often than prescribed. Excessive use can cause heart irregularities. Tell your doctor immediately if you experience chest pain, palpitations, rapid heart rate, or tremor.

Do not use Foradil with other long-acting beta2-agonists such as salmeterol.

What are possible food and drug interactions associated with Foradil Aerolizer?
If Foradil Aerolizer is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Foradil Aerolizer with the following: antibiotics such as clarithromycin and erythromycin, antidepressants categorized as tricyclics (such as amitriptyline and imipramine), antidepressants categorized as monoamine oxidase inhibitors (such as phenelzine and tranylcypromine), antifungals (such as fluconazole, itraconazole, and ketoconazole), beta-blockers used to control high blood pressure (such as atenolol and metoprolol), xanthine derivatives (such as theophylline), steroids (such as hydrocortisone and prednisone), and water pills (diuretics) such as furosemide and hydrochlorothiazide.

What are the possible side effects of Foradil Aerolizer?
Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

Side effects may include: anxiety, bronchitis, chest infection, chest pain, difficulty breathing, difficulty falling or staying asleep, difficulty speaking, dizziness, dry mouth, fast and irregular heart beat, fever, headache, high blood acid, inflammation of the tonsils or sinuses, itchiness, low blood potassium, muscle cramps, nausea, nervousness, rash, tiredness, tremor, upper respiratory tract infection, viral infection, worsening of asthma

Can I receive Foradil Aerolizer if I am pregnant or breastfeeding?
The effects of Foradil Aerolizer during pregnancy and breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

What should I do if I miss a dose of Foradil Aerolizer?
Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take two doses at once.

How should I store Foradil Aerolizer?
Store at room temperature, away from heat and moisture。


---------------------------------------------------------------
原产地英文商品名:
FORADIL AEROLIZER 12MCG/CAP 60CAPS/BOX
原产地英文药品名:
FORMOTEROL FUMARATE
原产地英文化合物名称:
n-(2-hydroxy-5-(1-hydroxy-2-((2-(4-methoxyphenyl)-1-methylethyl)amin;o)ethyl)phenyl)-,(e)-2-butenedioate(2:1)(salt)
中文参考商品译名:
FORADIL AEROLIZER 12微克/胶囊 60胶囊/盒
中文参考药品译名:
富马酸福莫特罗
中文参考化合物名称:
N-[2-羟基-5[(RS)-1-羟基-2-[(RS)-2-(4-甲氧基苯基)-1-甲基乙基胺]乙基]苯基]甲酰胺半富马酸
生产厂家中文参考译名:
诺华
生产厂家英文名:
NOVARTIS

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