药品信息:
To reduce the development of drug-resistant bacteria and maintain the effectiveness of BIAXIN and other antibacterial drugs, BIAXIN should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

What is Biaxin?
 
Biaxin is in a group of drugs called macrolide antibiotics. It fights bacteria in your body.
Biaxin is used to treat many different types of bacterial infections affecting the skin and respiratory system. It is also used together with other medicines to treat stomach ulcers caused by Helicobacter pylori.

Biaxin may also be used for other purposes not listed in this medication guide.

Important information about Biaxin

Do not use Biaxin if you are also using any of the drugs listed below. They can interact with Biaxin and cause life-threatening heart rhythm disorders:

cisapride (Propulsid);

pimozide (Orap); or

ergot medicine such as ergotamine (Ergomar, Ergostat, Cafergot, Ercaf, Wigraine), or dihydroergotamine (D.H.E.45, Migranal Nasal Spray).
Take Biaxin for the entire length of time prescribed by your doctor. Biaxin is usually given for 7 to 14 days (or longer when treating stomach ulcer). Your symptoms may get better before the infection is completely treated. Biaxin will not treat a viral infection such as the common cold or flu.

Before taking Biaxi

Do not use Biaxin if you are allergic to clarithromycin or to similar medicines such as azithromycin (Zithromax), dirithromycin (Dynabac), erythromycin (E.E.S., E-Mycin, Ery-Tab, Erythrocin), or troleandomycin (Tao). Do not use Biaxin if you are also using any of the drugs listed below. They can interact with Biaxin and cause life-threatening heart rhythm disorders:

cisapride (Propulsid);

pimozide (Orap); or

ergot medicine such as ergotamine (Ergomar, Ergostat, Cafergot, Ercaf, Wigraine), or dihydroergotamine (D.H.E. 45, Migranal Nasal Spray).
If you have any of these other conditions, you may need a dose adjustment or special tests to safely take Biaxin:

liver disease;

kidney disease;

myasthenia gravis;

porphyria; or

a personal or family history of "Long QT syndrome."
FDA pregnancy category C. It is not known whether Biaxin is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether Biaxin passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not give this medicine to a child younger than 6 months of age.
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部分中文克拉霉素处方资料（仅供参考）

【作用与用途】
抗菌谱与红霉素相似，对胃酸稳定，对革兰阳性菌作用更强，对部分革兰阴性菌、链球菌属、支原体及衣原体等均有抗菌活性。对肺炎链球菌、化脓性链球菌、金葡菌、卡他莫拉菌、流感嗜血杆菌及肺炎支原体等有效。临床主用于支气管炎、肺炎、咽喉炎、扁桃体炎、支原体肺炎、皮肤及软组织感染、中耳炎、牙周炎、百日咳、猩红热。
【剂量与用法】
口服，成人，0.25g/次，2次/日；严重感染可增加至0.5g/次，2次/日，根据病情连续服用6～14日。儿童每日10mg～15mg/kg，分2～3次给予。
【副作用】
1 胃肠道反应有恶心、呕吐、胃部不适、腹胀，食欲不振及软便等，偶有转氨酶上升。
2 对大环内酯类药物有过敏史者慎用。如出现皮疹等过敏症状时须停药。
3 孕妇禁用，哺乳妇慎用。
【补充资料】
克拉霉素又名甲红霉素，是红霉素的衍生物，上世纪90年代初由日本大正公司开发成功，并以商品名Clarith注册。尔后，大正公司首先将其技术转让给美国雅培公司生产；1990年在爱尔兰、意大利上市，1991年10月获FDA批准定为IB类新药上市，商品名Biaxin，1993年以Klacid在中国香港上市，在欧洲和亚洲的商品名为克拉仙，目前已在全球50多个国家上市，市场用量稳步增长，并在临床中发挥了重要作用。克拉霉素及其片剂、胶囊已收载入中国药典2000年版（注：2005版药典收录在二部第232页），目前生产的剂型还有颗粒剂、分散片、缓释片、注射剂和干混悬剂。
克拉霉素具有高效、口服易于吸收，对酸稳定性好的特点，该药对革兰阳性菌的活性强，对酶稳定，在血清和肺组织中浓度高。临床证明体内活性是红霉素的6～10倍，是交沙霉素的14～35倍。并以改善生物利用度为特征，组织和细胞内分布极好、半衰期长，其不良反应发生率仅为3%，是用于治疗上呼吸道及下呼吸道和皮肤、软组织感染，已成为取代红霉素的大环内酯类抗生素品种。此外，美国FDA已批准将克拉霉素与洛赛克合用，作为幽门螺旋杆菌引起的胃及十二指肠溃疡的治疗方案；该药也是治疗艾滋病患者感染的首选药物。
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原产地英文商品名:
CLARITHROMYCIN 250mg
原产地英文药品名:
CLARITHROMYCIN
中文参考商品译名:
Generic BIAXIN 250毫克/片 60片/盒
中文参考药品译名:
克拉霉素
该药品相关信息网址1:
http://www.biaxin.com/
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原产地英文商品名:
CLARITHROMYCIN 500mg
原产地英文药品名:
CLARITHROMYCIN
中文参考商品译名:
Generic BIAXIN 500毫克/片 30片/盒
中文参考药品译名:
克拉霉素