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枸橼酸托瑞米芬片Fareston(Toremifene Tablets)

2012-12-31 22:18:02 作者：新特药房来源：互联网浏览次数：200 文字大小：【大】【中】【小】

简介： 英文药名: Fareston(Toremifene Tablets) 中文药名: 法乐通（枸橼酸托瑞米芬片）药品说明药品英文名 Toremifene 药品别名氯三苯氧胺、托咪酚、氯他莫昔芬、法乐通、Fareston 药物剂型片剂： ...

关键字：枸橼酸托瑞米芬片转移性乳腺癌

英文药名: Fareston(Toremifene Tablets)

中文药名: 法乐通（枸橼酸托瑞米芬片）

药品说明

药品英文名
Toremifene

药品别名
氯三苯氧胺、托咪酚、氯他莫昔芬、法乐通、Fareston

药物剂型
片剂：20mg，60mg。

药理作用
本品为非甾体类三苯乙烯的衍生物。其抗肿瘤作用机制除了与他莫昔芬一样竞争性地与乳腺癌细胞浆内的雌激素受体(ER)结合、阻止癌细胞增殖分化外，还能诱导转化具有肿瘤抑制作用的生长因子(β-TGF)的产生和通过癌细胞的基因调节诱导癌细胞的程序性死亡。体外实验显示，TOR具有很强的抑制ER阳性人乳腺癌细胞系(MCF-7及ZR-75-1)生长的作用，其抑制强度与药物浓度有关。它抗雌激素作用强，而类雌激素作用较轻，其抗雌激素作用与类雌激素作用的比值是TAM的4倍。此外，TOR在高剂量时(3μmol/L)还具有抗雌激素受体依赖性抗肿瘤作用的特点。

药动学
口服吸收良好，tmax为2～4h，分布半衰期为4h，清除半衰期为5天。主要在肝内代谢转化，经胆汁、大便排出体外，只有小部分(＜10%)代谢产物从肾脏排出。

适应证
乳腺癌和子宫内膜癌。

禁忌证
有血栓栓塞病史者禁用。

注意事项
尚不明确。

不良反应
1.消化道反应：恶心、呕吐、腹部不适、厌食、腹泻、便秘、食欲增加等，多不严重。
2.内分泌症状：面部潮红、阴道排液、阴道出血、眩晕、失眠等。
3.其他：偶有过敏、高钙血症、血栓栓塞、口痛、乳房痛、视力减弱、眼干、血小板及白细胞减少等。

用法用量
1.目前推荐一线治疗乳腺癌为60mg，每天1次，口服；
2.二线、三线用量为每天200～240mg，1次或分次口服。

药物相应作用
1.与噻嗪类利尿剂、华法林类抗凝剂及癫痫药物有相互作用。
2.能降低钙排泄。

专家点评
托瑞米芬为一新型抗雌激素类药物，作用机制与TAM相似，与TAM有交叉耐药性。对乳腺癌的疗效与TAM相同或略高，但不良反应轻微，长期用药未发现类似于TAM所致的子宫内膜癌、增生性结节及视网膜改变等不良反应。使用较高剂量对乳腺癌疗效更好，已成为治疗乳腺癌的一线药物。

Fareston Generic Name: Toremifene (TORE-em-i-feen)Brand Name: Fareston
Fareston is used for:
Treating breast cancer in women past menopause with estrogen-dependent tumors or unknown tumors. It may also be used for other conditions as determined by your doctor.
Fareston is an antiestrogen. It works by blocking the effects of estrogen on certain body tissues, including breast tissue. This helps block the growth of estrogen-activated tumors.
Do NOT use Fareston if:
you are allergic to any ingredient in Fareston
Contact your doctor or health care provider right away if any of these apply to you.
Before using Fareston :
Some medical conditions may interact with Fareston . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have bone cancer or a growth of the endometrium
if you have a history of blood clots, cancer, or decreased blood platelets or white blood cells
Some MEDICINES MAY INTERACT with Fareston . Tell your health care provider if you are taking any other medicines, especially any of the following:
Ketoconazole or macrolide antibiotics (eg, erythromycin) because the actions and side effects of Fareston may be increased
Fluorouracil, mitomycin C, or thiazide diuretics (eg, hydrochlorothiazide) because the risk of side effects may be increased
Carbamazepine, phenobarbital, or rifampin because the effectiveness of Fareston may be decreased
Anticoagulants (eg, warfarin) or hydantoins (eg, phenytoin) because the actions and side effects of these medicines may be increased
This may not be a complete list of all interactions that may occur. Ask your health care provider if Fareston may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Fareston :
Use Fareston as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Fareston may be taken with or without food.
If you miss a dose of Fareston , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Fareston .
Important safety information:
Fareston may cause dizziness or changes in vision. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Fareston . Using Fareston alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
If Fareston causes nausea or vomiting, ask your doctor or pharmacist about ways to minimize this effect.
LAB TESTS, including complete blood cell counts, calcium levels, and liver function tests, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
Fareston is not recommended for use in CHILDREN. Safety and effectiveness have not been confirmed.
PREGNANCY and BREAST-FEEDING: Fareston has been shown to cause harm to the fetus. If you become pregnant, discuss with your doctor the benefits and risks of using Fareston during pregnancy. It is unknown if Fareston is excreted in breast milk. If you are or will be breast-feeding while you are using Fareston , check with your doctor or pharmacist to discuss the risks to your baby.
Possible side effects of Fareston :
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Dizziness; hot flashes; joint pain; loss of appetite; nausea; sweating; swelling of the hands or feet; tiredness; vaginal discharge; vomiting.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); change in vision; chest pain; confusion; depression; flushing; hallucinations; irregular heartbeat; muscle pain; unusual bleeding or bruising ; vaginal bleeding .
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include dizziness; hallucinations; headache; hot flashes; nausea; loss of coordination; vaginal bleeding; vomiting.
Proper storage of Fareston :
Store Fareston at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Fareston out of the reach of children and away from pets.
附件:
201232019353139.PDF

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注：以下产品不同规格和不同价格，购买时请以电话咨询为准！
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产地国家: 美国
原产地英文商品名:
FARESTON 60mg/Tab 100Tabs/box
原产地英文药品名:
TOREMIFENE CITRATE
中文参考商品译名:
法乐通 60毫克/片 100片/盒
中文参考药品译名:
枸橼酸托瑞米芬
生产厂家中文参考译名:
GTX INC
生产厂家英文名:
GTX INC

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产地国家: 美国
原产地英文商品名:
FARESTON 60mg/Tab 30Tabs/box
原产地英文药品名:
TOREMIFENE CITRATE
中文参考商品译名:
法乐通 60毫克/片 30片/盒
中文参考药品译名:
枸橼酸托瑞米芬
生产厂家中文参考译名:
GTX INC
生产厂家英文名:
GTX INC