部分中文Prevacid处方资料（仅供参考）
【药理毒理】
本药转移到胃粘膜壁细胞的酸分泌细管后，在酸性条件下，转变为活性体结构，此种活性物与质子泵（（H+＋K+）-ATPase）的SH基结合，从而抑制该酶的活性，故能抑制胃酸的分泌。
1．（H+＋K+）-ATPase活性抑制作用，兰索拉唑可抑制狗胃粘膜内微粒体的（H+＋K+）-ATPase活性（体外实验）。
2．壁细胞酸生成抑制作用，兰索拉唑对狗胃粘膜离体壁细胞由组胺、乙酰胆碱及胃泌素的刺激所产生的酸分泌，皆具有抑制作用（体外实验）。
3．胃酸分泌抑制作用，
1）对胃泌素刺激引起的酸分泌：于健康成人，1天1次兰索拉唑30mg口服给药，连续7天，可明显地抑制由胃泌素引起的酸分泌，且此作用能持续24小时。
2）对胰岛素刺激引起的酸分泌：于健康成人，1天1次兰索拉唑30mg口服给药，连续7天，可明显地抑制由胰岛素引起的酸分泌。
3）对夜间的酸分泌：于健康成人，1天1次兰索拉唑30mg口服给药，连续7天，具有明显地抑制夜间胃酸分泌的作用。
4）对24小时的酸分泌：于健康成人24小时胃液采样试验，以1天1次兰索拉唑30mg口服给药连续7天，24小时的胃酸分泌明显地受到抑制。
5）24小时胃内pH值的监测：对健康成人以及十二指肠溃疡患者，以1天1次兰索拉唑30mg口服给药连续7天，24小时的胃酸分泌皆明显地受到抑制。
6）24小时下部食道pH值的监测：于反流性食管炎患者，以1天1次兰索拉唑30mg口服给药连续7天～9天，对胃食管反流现象，有明显地抑制作用。
7）对大白鼠及胃pouch狗的胃酸分泌：本药对于大白鼠的基础酸分泌和因组胺、胃泌素、氨基甲酰基胆碱、2-脱氧-D-葡萄糖或水浸应激试验（water immersion stress）所引起的酸分泌均能明显且持续地抑制（在十二指肠内）。对胃pouch狗因各种刺激所引起的酸分泌，本药亦有明显且持续地抑制作用，在反复给药期间，均能显示稳定的酸分泌抑制作用（经口给药）。
4．慢性溃疡的治愈促进作用，于大白鼠的实验，兰索拉唑能明显地促进由醋酸引起的慢性胃及十二指肠溃疡的愈合（经口给药）。
5．溃疡形成的抑制作用，于大白鼠的实验，对因水浸应激试验、阿司匹林或乙醇引起的胃溃疡，及因mepirisol或半胱胺引起的十二指肠溃疡，和反流性食管炎皆有明显的抑制作用（经口或十二指肠内给药）。
【药代动力学】
1．血中浓度
兰索拉唑的生物利用度具有个体差异性。于空腹或餐后对健康成人（6例）经口给予1次30mg的药量时，血中主要检测到药物原形，其代谢物亦可测得。空腹服药的Tmax为2.2± 0.4h，Cmax为1038± 323ng/ml，T1/2为1.44± 0.94h，AUC为3890± 2484 ng· h/ml。餐后服药的Tmax为3.5± 0.8h，Cmax为679± 359ng/ml，T1/2为1.60±0.90h，AUC为 3319± 2651ng· h/ml。尿中未能检出兰索拉唑的原形，只检出其代谢物，至服用后24小时为止，其尿中排泄率为13.1～14.3%。此外，对健康成人（6例），晨间空腹时，经口给予兰索拉唑30mg1天1次，连续7天，由血中浓度的变化及尿中排泄率来观察，体内无蓄积性。
【适应症】
胃溃疡、十二指肠溃疡、反流性食管炎、卓-艾综合征（Zollinger-Ellison症候群）、吻合口部溃疡。
【用法用量】
十二指肠溃疡，通常成人每日一次，口服兰索拉唑15mg～30mg，连续服用4～6周；胃溃疡、反流性食管炎、卓-艾综合征（Zollinger-Ellison症候群）、吻合口部溃疡，通常成人每日一次，口服兰索拉唑30mg，连续服用6～8周。但用做维持治疗、高龄者、有肝功能障碍、肾功能低下的患者，每日一次，口服兰索拉唑15mg。
【不良反应】
1）过敏症：偶有皮疹、瘙痒等症状，如出现上述症状时请停止用药。
2）肝脏：偶有GOT、GPT、ALP、LDH、γ-GTP上升等现象，所以须细心观察，如有异常现象应采取停药等适当的处置。
3）血液：偶有贫血、白细胞减少，嗜酸球增多等症状，血小板减少之症状极少发生。
4）消化器：偶有便秘，腹泻，口渴，腹胀等症状。
5）精神神经系统：偶有头痛、嗜睡等症状。失眠，头晕等症状极少发生。
6）其它：偶有发热，总胆固醇上升，尿酸上升等症状。
【禁忌】
对本品过敏者禁用
【注意事项】
1．在治疗过程中，应充分观察，按其症状使用治疗上所需最小剂量。
2．下列患者慎重用药
1）曾发生药物过敏症的患者
2）肝功能障碍的患者
3．其它
对大白鼠经口给药52周的实验，50mg/kg/日组（约为临床用量的100倍），发现1例有良性精巢间细胞瘤。于大白鼠经口给药24个月的实验，15mg及50mg/kg/日组中，精巢间细胞瘤发生率会增加，在50mg/kg/日组中发现1例雌大白鼠有胃部类癌（carcinoid）出现。
因本药会掩盖胃癌的症状，所以须先排除胃癌，方可给药。
【孕妇及哺乳期妇女用药】
1．已确认兰索拉唑在大白鼠胎仔的血浆浓度比在母鼠中高。又在兔子（经口给药30mg/kg）的实验发现胎仔死亡率增加，故对孕妇或有可能怀孕的妇女，需事先判断治疗上的益处超过危险性时，方可用药。
2．曾有报告指出，在动物实验中药品会转移到乳汁中。所以本药品不适合用于正在哺乳中的妇女。如不得已需服药时，应避免哺乳。
【儿童用药】
对儿童用药的安全性尚未确立（由于在小儿的临床经验极少）。
【老年患者用药】
一般而言，老年患者的胃酸分泌能力和其他生理机能均会降低，故用药期间请注意观察。
【药物相互作用】
会延迟安定（diazepam）及苯妥英钠（phenytoin）的代谢与排泄，资料已被发表于类似药物奥美拉唑的报告中。
【贮藏】
密封，在干燥处保存
Generic Name: lansoprazole
PREVACID 30 has been identified as Prevacid 30 mg.
Prevacid is used in the treatment of stomach ulcer; gerd; barrett's esophagus; erosive esophagitis; nsaid-induced ulcer prophylaxis (and more), and belongs to the drug class proton pump inhibitors. There is no proven risk in humans during pregnancy.
Prevacid 30 mg is not subject to the Controlled Substances Act.
Prevacid Delayed-Release CapsulesGeneric Name: Lansoprazole (lan-SOE-pra-zole)Brand Name: Prevacid
Prevacid Delayed-Release Capsules are used for:
Preventing or treating certain types of ulcers. It is also used to treat symptoms of gastroesophageal reflux disease (GERD) (eg, heartburn) and irritation of the esophagus. It is also used to treat conditions that cause your body to make too much stomach acid (eg, Zollinger-Ellison syndrome). It may also be used for other conditions as determined by your doctor.
Prevacid Delayed-Release Capsules are a proton pump inhibitor. It works by decreasing the amount of acid produced in the stomach.
Do NOT use Prevacid Delayed-Release Capsules if:
you are allergic to any ingredient in Prevacid Delayed-Release Capsules
you are taking an HIV protease inhibitor (eg, atazanavir)
Contact your doctor or health care provider right away if any of these apply to you.
Before using Prevacid Delayed-Release Capsules:
Some medical conditions may interact with Prevacid Delayed-Release Capsules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have liver problems or stomach or bowel cancer
Some MEDICINES MAY INTERACT with Prevacid Delayed-Release Capsules. Tell your health care provider if you are taking any other medicines, especially any of the following:
Clarithromycin or voriconazole because they may increase the risk of Prevacid Delayed-Release Capsules's side effects
Anticoagulants (eg, warfarin) or digoxin because the risk of their side effects may be increased by Prevacid Delayed-Release Capsules
Azole antifungals (eg, ketoconazole), clopidogrel, HIV protease inhibitors (eg, atazanavir), iron, or theophylline because their effectiveness may be decreased by Prevacid Delayed-Release Capsules
This may not be a complete list of all interactions that may occur. Ask your health care provider if Prevacid Delayed-Release Capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Prevacid Delayed-Release Capsules:
Use Prevacid Delayed-Release Capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Take Prevacid Delayed-Release Capsules by mouth on an empty stomach before eating.
Swallow Prevacid Delayed-Release Capsules whole. Do not break, crush, or chew before swallowing.
If you have trouble swallowing the capsule, open it and sprinkle the granules on 1 tablespoon (15 mL) of applesauce, Ensure pudding, cottage cheese, yogurt, or strained pears. Swallow at once. Do not chew or crush the granules. Do not store the mixture for use at a later time.
You may also open the capsule and sprinkle the granules into 2 oz (60 mL) apple juice, orange juice, or tomato juice. Mix briefly, then swallow at once. Do not chew or crush the granules. Do not store the mixture for use at a later time. After you take your dose, rinse the glass with at least 4 oz (120 mL) of juice and swallow to be sure you have received all of the medicine.
Do NOT mix Prevacid Delayed-Release Capsules with other foods or liquids.
You may take antacids while you are using Prevacid Delayed-Release Capsules if you are directed to do so by your doctor.
If you are also taking an imidazole antifungal (eg, ketoconazole), take it at least 2 hours before taking Prevacid Delayed-Release Capsules.
If you also take sucralfate, take Prevacid Delayed-Release Capsules at least 30 minutes before taking sucralfate.
Continue to take Prevacid Delayed-Release Capsules even if you feel well. Do not miss any doses.
If you miss a dose of Prevacid Delayed-Release Capsules, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Prevacid Delayed-Release Capsules.
Important safety information:
Prevacid Delayed-Release Capsules may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Prevacid Delayed-Release Capsules with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
Contact your doctor if you have any symptoms of a bleeding ulcer, such as black, tarry stools or vomit that looks like coffee grounds; or if you experience throat pain, chest pain, severe stomach pain, or trouble swallowing.
Prevacid Delayed-Release Capsules may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Prevacid Delayed-Release Capsules.
Prevacid Delayed-Release Capsules should be used with caution in Asian patients; the risk of side effects may be increased in these patients.
Prevacid Delayed-Release Capsules should be used with extreme caution in CHILDREN younger than 1 year old; safety and effectiveness in these children have not been confirmed.
PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Prevacid Delayed-Release Capsules while you are pregnant. It is not known if Prevacid Delayed-Release Capsules are found in breast milk. Do not breast-feed while taking Prevacid Delayed-Release Capsules.
Possible side effects of Prevacid Delayed-Release Capsules:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Constipation; diarrhea; headache; nausea; stomach pain.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); chest pain; fast or irregular heartbeat; fever, chills, or sore throat; red, swollen, blistered, or peeling skin; seizure; unusual bruising or bleeding; unusual tiredness; vision changes.

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注：以下产品不同的规格和不同的价格，购买时请以电话咨询为准！
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产地国家: 美国
原产地英文商品名:
PREVACID capsule DR 30mg/capsule 100capsules/box
原产地英文药品名:
LANSOPRAZOLE
中文参考商品译名:
PREVACID缓释胶囊 30毫克/胶囊 100胶囊/盒
中文参考药品译名:
兰索拉唑
生产厂家中文参考译名:
武田/诺华
生产厂家英文名:
TAKEDA/NOVARTIS
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产地国家: 美国
原产地英文商品名:
PREVACID capsule DR 15mg/capsule 100capsules/box
原产地英文药品名:
LANSOPRAZOLE
中文参考商品译名:
PREVACID缓释胶囊 15毫克/胶囊 100胶囊/盒
中文参考药品译名:
兰索拉唑
生产厂家中文参考译名:
武田/诺华
生产厂家英文名:
TAKEDA/NOVARTIS