部分中文卡铂处方资料（仅供参考）
【药品名称】
药物别名：卡铂
英 文 名：Carboplatin
化学名：顺式-1，1-环丁烷二羧酸二氨铂。分子式：C6H12N2O4Pt。分子量：371.26。
【药物类别】
铂类化疗药
【药理毒理】
卡铂为第二代铂类抗癌药；肾毒性、胃肠道反应、耳毒性和神经毒性较轻；药物易溶解，不需水化利尿，使用方便。
药代动力学： 卡铂为细胞周期非特异性药物其作用与DDP相似，主要能引起靶细胞 DNA的交叉联结，阻碍DNA合成，同时阻止DNA复制，从而抑制肿瘤细胞的生长适应症。
主要适用于小细胞肺癌、卵巢癌、睾丸癌、头颈部鳞癌，亦可用于非小细胞肺癌、膀胱癌、胸膜间皮瘤、子宫颈癌和子宫内膜癌等
【适应症】
主要用于卵巢癌、小细胞肺癌、非小细胞肺癌、头颈部鳞癌、食管癌、精原细胞瘤、膀胱癌、间皮瘤等。
【禁忌症】
1.有明显骨髓抑制和肝肾功能不全者；
2.对顺铂或其他含铂化合物过敏者；
3.对甘露醇过敏者。
【用法用量】
每次剂量：单药为400mg/m2，联合用药为300mg/m2，先用5%葡萄糖液制成10mg/ml溶液，再加入5%葡萄糖液250-500ml，静脉滴注。亦可将上述剂量分为5次给药，每日1次，静脉滴注。每4周重复作为一周期，3周期为一疗程。
【不良反应】
1.常见的反应：
①骨髓抑制为剂量限制毒性，白细胞与血小板在用药21日后达最低点，通常在用药后30日左右恢复；粒细胞的最低点发生于用药后21～28日，通常在35日左右恢复；白细胞与血小板减少与剂量相关，有蓄积作用；
②注射部位疼痛。
2.较少见的反应：
①过敏反应(皮疹或搔痒，偶见喘咳)，发生于用药后几分钟之内；
②周围神经毒性：指或趾麻木或麻刺感；
③耳毒性：高频率的听觉丧失首先发生，耳鸣偶见；
④视力模糊、粘膜炎或口腔炎；
⑤恶心及呕吐、便秘或腹泻、食欲减退、脱发及头晕，偶见变态反应和肝功能异常。
【注意事项】
1.应用本品前应检查血象及肝肾功能，治疗期间至少每周检查1次白细胞与血小板；
2.带状疱疹、感染、肾功能减退者慎用。
3.静脉注射时应避免漏于血管外。
4.本品溶解后，应在8小时内用完。
5.滴注及存放时应避免直接日晒。
6.用药期间应随访检查：
①听力；
②神经功能；
③血尿素氮，肌酐清除率与血清肌酐测定；
④红细胞压积，血红蛋白测定，白细胞分类与血小板计数；
⑤血清钙、镁、钾、钠含量的测定。
Carboplatin Generic Name:
Carboplatin Brand Name: Paraplatin
Carboplatin may cause severe allergic reactions, bone marrow suppression, and anemia. Contact your doctor immediately if you develop symptoms of a severe allergic reaction (eg, rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue), symptoms of infection (eg, fever, chills, sore throat), or unusual bruising or bleeding. Vomiting is a common side effect of Carboplatin . Talk with your doctor about ways to decrease this side effect.
Carboplatin is used for:
Treating ovarian cancer. It may also be used for other conditions as determined by your doctor.
Carboplatin is an antineoplastic. It works by disrupting the cell growth of cancer cells, which helps you fight cancer.
Do NOT use Carboplatin if:
you are allergic to any ingredient in Carboplatin , mannitol, or compounds that contain platinum (eg, cisplatin)
you have severe bone marrow depression or severe bleeding problems
Contact your doctor or health care provider right away if any of these apply to you.
Before using Carboplatin :
Some medical conditions may interact with Carboplatin . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have impaired kidney function or liver problems
Some MEDICINES MAY INTERACT with Carboplatin . Tell your health care provider if you are taking any other medicines, especially any of the following:
Aminoglycoside antibiotics (eg, gentamicin) and anticoagulants (eg, warfarin) because side effects, including risk of bleeding, kidney problems, or hearing problems, may be increased by Carboplatin Hydantoins (eg, phenytoin) because the effectiveness of these medicines may be decreased
This may not be a complete list of all interactions that may occur. Ask your health care provider if Carboplatin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Carboplatin :
Use Carboplatin as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Carboplatin is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using Carboplatin at home, carefully follow the injection procedures taught to you by your health care provider.
Carboplatin comes with an additional patient leaflet. Read it carefully and reread it each time you get Carboplatin refilled.
If Carboplatin contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
If Carboplatin accidentally spills on your skin, wash it off immediately with soap and water.
Keep this product, as well as syringes and needles, out of the reach of children. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
If nausea, vomiting, or loss of appetite occur, ask your doctor or pharmacist for ways to lessen these effects.
If you miss a dose of Carboplatin , contact your doctor immediately.
Ask your health care provider any questions you may have about how to use Carboplatin .
Important safety information:
Carboplatin may reduce the number of clot-forming cells (platelets) in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Report any unusual bleeding, bruising, blood in stools, or dark, tarry stools to your doctor.
Carboplatin may lower your body's ability to fight infection. Prevent infection by avoiding contact with people with colds or other infections. Notify your doctor of any signs of infection including fever, sore throat, rashes, or chills.
Avoid vaccinations with live virus vaccines (eg, measles, mumps, oral polio) while you are taking Carboplatin . Vaccinations may be less effective.
LAB TESTS, including blood counts, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
Use Carboplatin with caution in the ELDERLY because they may be more sensitive to its effects.
Use Carboplatin with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.
PREGNANCY and BREAST-FEEDING: Carboplatin has been shown to cause harm to the fetus. Avoid becoming pregnant while taking Carboplatin . If you think you may be pregnant, discuss with your doctor the benefits and risks of using Carboplatin during pregnancy. It is unknown if Carboplatin is excreted in breast milk. Do not breast feed while taking Carboplatin .
Possible side effects of Carboplatin :
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Constipation; diarrhea; hair loss; loss of appetite; nausea; stomach pain; vomiting; weakness.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); cough; decrease in amount of urine; fever or chills; injection site reactions (redness, swelling, pain); numbness, tingling, or pain of the hands or feet; pain, irritation, or sores in the mouth; ringing in the ears or hearing loss; sore throat; unusual bruising or bleeding; vision changes or loss.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center , or emergency room immediately. Symptoms may include loss of vision (which can be complete for light and colors); severe stomach pain; yellowing of skin or eyes.
Proper storage of Carboplatin :
Carboplatin is usually handled and stored by a health care provider. If you are using Carboplatin at home, store Carboplatin as directed by your pharmacist or health care provider.
General information:
If you have any questions about Carboplatin , please talk with your doctor, pharmacist, or other health care provider.
Carboplatin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.

附件:

201111121511730.pdf
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注：以下产品不同规格和不同价格，购买时请以电话咨询为准！
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产地国家: 美国
原产地英文商品名:
CARBOPLATIN LYOF POWD 150mg/vial
原产地英文药品名:
CARBOPLATIN
中文参考商品译名:
卡铂LYOF粉 150毫克/瓶
中文参考药品译名:
卡铂
中文参考化合物名称:
顺式-1，1-环丁烷二羧酸二氨铂
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产地国家: 美国
原产地英文商品名:
CARBOPLATIN LYOF POWD 50mg/vial
原产地英文药品名:
CARBOPLATIN
中文参考商品译名:
卡铂LYOF粉 50毫克/瓶
中文参考药品译名:
卡铂
中文参考化合物名称:
顺式-1，1-环丁烷二羧酸二氨铂