部份拜瑞妥中文处方资料(仅供参考)
药品说明
拜瑞妥 薄膜衣片 [Xarelto®]
成份: 利伐沙班 Rivaroxaban
原研厂家:德国拜耳
适应症:用于择期髋关节或膝关节置换手术成年患者,以预防静脉血栓形成(VTE)
产品特点
利伐沙班是全球第一个高选择性直接抑制因子Xa的口服抗凝药。通过直接抑制因子Xa可以中断凝血瀑布的内源性和外源性途径,抑制凝血酶的产生和血栓形成。利伐沙班技术转让利伐沙班技术转让利伐沙班技术转让利伐沙班片是唯一的一种疗效始终优于依诺肝素的新型口服抗凝药,日服一次,膝关节置换术后患者应连续服用12天,髋关节置换术后患者应连续服用35天。利伐沙班技术转让利伐沙班技术转让利伐沙班技术转让此药物还有预防房颤患者中风的预防和其它临床疾病的潜力。利伐沙班已在全球100多个国家获得批准,并由拜耳公司在超过75个国家成功上市。
药理毒性
利伐沙班高度选择性和可竞争性抑制游离和结合的Xa因子以及凝血酶原活性,以剂量-依赖方式延长活化部分凝血活酶时间板(PT)和凝血酶原时间(aPTT)。利伐沙班与磺达肝素钠/肝素的本质区别在于它不需要抗凝血酶III参与,可直接拮抗游离和结合的Xa因子。而肝素则需要有抗凝血酶III才能发挥作用,且对凝血酶原复合物中的Xa因子无效。
适应症
用于预防髋关节和膝关节置换术后患者深静脉血栓(DVT)和肺栓塞(PE)的形成。也可用于预防非瓣膜性心房纤颤患者脑卒中和非中枢神经系统性栓塞,降低冠状动脉综合症复发的风险等。
See related Xarelto film-coated tab information
Manufacturer Bayer HealthCare Pharma
Distributor DKSH
Contents Rivaroxaban
Indications Prevention of VTE in patients undergoing major orthopaedic surgery of the lower limbs.
Click to view Xarelto detailed prescribing infomation
Dosage 1 tab once daily for 5 wk (major hip surgery) or 2 wk (major knee surgery). Initial dose to be taken 6-10 hr after surgery provided that hemostasis has been established.
Click to view Xarelto detailed prescribing infomation
Overdosage View Xarelto overdosage for action to be taken in the event of an overdose.
Administration May be taken with or without food
Contraindications Clinically significant active bleeding. Hepatic disease associated w/ coagulopathy leading to a clinically relevant bleeding risk. Pregnancy & lactation.
Click to view Xarelto detailed prescribing infomation
Special Precautions Moderate to severe renal impairment, congenital or acquired bleeding disorders; uncontrolled severe arterial HTN; active & recent GI ulcerations; vascular retinopathy; recent intracranial or intracerebral hemorrhage, intraspinal or intracerebral vascular abnormalities; recent brain, spinal or ophthalmological surgery; hip fracture surgery; spinal/epidural anesth or puncture. Women of childbearing potential. Concomitant NSAIDs, platelet aggregation inhibitors, other antithrombotics.
Click to view Xarelto detailed prescribing infomation
Adverse Drug Reactions Increased γ-glutamyl transferase & transaminases (ALT & AST); anaemia; nausea; postprocedural haemorrhage.
View ADR Monitoring Form
Drug Interactions Azole antimycotics, HIV-PIs, clopidogrel.
View more drug interactions with Xarelto
Storage View Xarelto storage conditions for details to ensure optimal shelf-life.
Mechanism of Action View Xarelto mechanism of action for pharmacodynamics and pharmacokinetics details.
包装[注:部份包装规格的价格以咨询为准]
錠剤
10mg PTP包装 100錠(10錠×10),140錠(14錠×10),500錠(10錠×50)
*バラ包装 500錠
15mg PTP包装 100錠(10錠×10),140錠(14錠×10),500錠(10錠×50)
*バラ包装 500錠
製造販売元(輸入)
バイエル薬品株式会社
完整处方资料附件:http://www.info.pmda.go.jp/go/pack/3339003F1024_1_04/
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产地国家:日本
原产地英文商品名:
Xarelto(イグザレルト錠)10mg/tab 100Tablets/box
原产地英文药品名:
Rivaroxaban
中文参考商品译名:
拜瑞妥(イグザレルト錠)10毫克/片 100片/盒
中文参考药品译名:
利伐沙班
生产厂家中文参考译名:
拜耳
生产厂家英文名:
Bayer
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产地国家:日本
原产地英文商品名:
Xarelto(イグザレルト錠)15mg/tab 100Tablets/box
原产地英文药品名:
Rivaroxaban
中文参考商品译名:
拜瑞妥(イグザレルト錠)15毫克/片 100片/盒
中文参考药品译名:
利伐沙班
生产厂家中文参考译名:
拜耳
生产厂家英文名:
Bayer