英文藥名：DEMUNARON（Teprenone）

中文藥名：替普瑞酮胶囊/颗粒剂

生 產 商：鶴原製薬
藥品介紹
【药理与适用症】: 替普瑞酮为一种萜类物质，具有组织修复作用，特别能强化抗溃疡作用。替普瑞酮能促进胃粘膜微粒体中糖脂质中间体的生物合成，进而加速胃粘膜及胃粘液层中主要的粘膜修复因子即高分子糖蛋白的合成，提高粘液中的磷脂质浓度，从而提高粘膜的防御功能。替普瑞酮不影响胃的正常生理功能，如胃液分泌及胃运动功能。对盐酸、阿司匹林及酒精所致溃疡替普瑞酮具有细胞保护作用，而H2受体拮抗剂和抗胆碱药则无此作用。替普瑞酮还能改善氢化可的松引起的胃粘膜增殖区细胞繁殖能力低下，保持胃粘膜细胞增殖区的稳定性，促使损伤愈合。替普瑞酮并能提高正常大鼠胃体部与幽门间粘膜中PGE2的合成能力，改善失血应激及固定水浸应激引起的胃粘膜血流量低下。
12名健康入以交叉法口服胶囊或颗粒剂150mg，tmax为5小时，胶囊剂的Cmax为1669ng／ml，颗粒剂则为1296ng／ml，以后逐渐减少，10小时后再次达峰值，胶囊剂者为675ng／ml，颗粒剂者为604ng／ml，呈双相性，两种剂型生物利用度未见差异。溃疡患者饭前30分钟或饭后30分钟内服用替普瑞酮150mg，其AUC比空腹服用时高30—45倍。替普瑞酮在组织中的分布浓度高于血浓度；临床研究了替普瑞酮的胃内分布，结果证实替普瑞酮在溃疡部位的平均浓度较周围组织高约10倍。
主要用于胃溃疡。
【注意事项】
1.对妊娠妇女及儿童用药的安全性尚未确定，孕妇儿童应慎用。
2。总不良反应发生率约为2．22％，主要有便秘、腹胀、AST及ALT轻度升高、头痛、皮疹及总胆固醇升高等。上述不良反应一般在停药后即可消失。
【用法与用量】: 饭后30分钟内口服，每日3次，每次1粒胶囊(50mg)或颗粒剂0．5g(含替普瑞酮50mg)。
【性状】: 替普瑞酮为含不同几何异构体的油状混合物。
【包装】: 胶囊剂：每胶囊50mg；颗粒剂：100mg／g。
The medicine can have side effects not only the effect (benefit) (risk). To minimize adverse effects, it is important to effects and maximize efficacy. To do this, you must have the understanding and cooperation of patients who are using this medicine.
Product Name: Dem Naron capsule 50mg
Active ingredient: teprenone (Teprenone)
Dosage form: Haiao green / pale orange capsules, total length 14.0mm, 5.2mm diameter
Sheet described: Demunaron 50mg, TSU432,50mg, DEMUNARON
Effects of this medicine
To suppress the reduction of gastric mucus blood flow and increase mucus secretion addition to suppress the occurrence of gastric ulcer, and showed a mucosal protective effect, and promotes the protection and repair of gastric mucosa is damaged.
Normally, gastric ulcer treatment, gastric mucosal lesion of acute exacerbation of acute gastritis and chronic gastritis (erosion, bleeding, redness, swelling) and will be used to improve.
Please tell your doctor and pharmacist before you use experienced any of the following.
• Before using this medicine, itching, sometimes had any unusual or allergic reaction symptoms such as rash.
• If you are pregnant or breastfeeding.
• you are using the other to medicine (you can strengthen the effect on each other, so there is also likely to weaken, please be aware of the drug being used in the other, including the-counter drugs).
(Proper use of this medicine) Dosage and administration
• Your dosage regimen is (doctor»)
• General dosage regimen: For adults, take once a capsule (50mg of the active ingredient) after meals three times a day, disease and age receive the treatment, it will be adjusted according to symptoms. Please follow the dosage instructions of always.
• If you forget to drink, please drink as soon as possible when you notice. However, by then drink time is not drink it was minute to forget if close, please do missed dose to the regular dosing schedule. This is not to drink at a time twice worth absolutely.
• Please consult your doctor or pharmacist if you took too much of this medicine by mistake.
• without the doctor's instructions, please do not stop taking the medicine on your own judgment.
Notes on life
• That where I am while taking care of using this medicine (side effects)
The main side effects, constipation, diarrhea, nausea, headache, rash, itching, etc. have been reported. If you notice such symptoms, please consult your doctor or pharmacist.
There are initial symptoms of the adverse effects that symptoms such as the following rarely appeared, indicated in brackets.
In such a case, stop using it, please seek medical attention immediately.
• general malaise, loss of appetite, yellowing of skin and whites of the eyes [liver dysfunction, jaundice]
Other side effects do not describe all. If you notice any symptoms of concern other than those mentioned above out, please consult your doctor or pharmacist.
Storage and other information
• infants, where it is not out of reach of children, direct sunlight, high temperature, please keep away the moisture.
• If the drug is remaining, please discard it.
原處方資料附件：http://www.info.pmda.go.jp/go/pack/2329012C1220_1_09/
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产地国家: 日本
原产地英文商品名:
DEMUNARON Capsules（デムナロンカプセル）50mg/Caps  100Caps
原产地英文药品名:
Teprenone
中文参考商品译名:
DEMUNARON胶囊（デムナロンカプセル）50毫克/胶囊 100胶囊/盒
中文参考药品译名:
替普瑞酮
生产厂家中文参考译名:
鶴原製薬
生产厂家英文名:
Tsuruhara Pharmaceutical
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产地国家: 日本
原产地英文商品名:
DEMUNARON Fine Granules10%（デムナロン細粒10%）100g
原产地英文药品名:
Teprenone
中文参考商品译名:
DEMUNARON顆粒10%（デムナロン細粒10% ） 100克/瓶
中文参考药品译名:
替普瑞酮
生产厂家中文参考译名:
鶴原製薬
生产厂家英文名:
Tsuruhara Pharmaceutical