部份中文坎地沙坦酯/氨氯地平LD £ HD资料（仅供参考）
通用名：
坎地沙坦酯氨氯地平片
英文名：
Candesartan  Cilexetil and Amlodipine Tablets
药品商标名：
UNISIA®Combination Tablets LD £ HD
适应症：
治疗高血压症。
规格：
8/2.5mg、8/5mg（坎地沙坦酯/氨氯地平）
用法用量：
成人1日1片（坎地沙坦酯/氨氯地平8mg/2.5mg或8mg/5mg）,口服给药。
国外上市情况
本品由日本武田制药公司开发,商品名为UNISIA®Combination Tablets LD £ HD,于2010年在日本上市。上市规格为8/2.5mg、8/5mg（坎地沙坦酯/氨氯地平）。

临床研究
药理、药效及其治疗优势
(1)药理作用：
坎地沙坦酯作用于血管紧张素Ⅱ受体，氨氯地平作用于钙离子通道。联合两种药物的降压作用，在对血管紧张素Ⅱ受体AT1拮抗的同时，舒张血管平滑肌，达到协同降压的目的，同时保护靶器官不受损害。
(2)作用机制：
血管紧张素Ⅱ的分泌和钙离子进入细胞都可使血管收缩，血流阻力增加，血压升高。血管紧张素受体拮抗剂和钙离子通道阻滞剂可以在拮抗血管紧张素受体的同时对减少钙离子进入血管壁细胞，达到降低血压的功效。
(3)组方特点:
本复方制剂将血管紧张素Ⅱ受体拮抗剂与钙拮抗剂联用。坎地沙坦酯作用于血管紧张素Ⅱ受体拮抗剂，减弱血管紧张素Ⅱ对血管的收缩作用。同时，氨氯地平作用于血管钙离子通道，减少钙离子进入血管细胞，达到舒张血管平滑肌的作用。两者在作用机制与作用位点上达到协同作用的目的，并且选用的复方剂量均为最低剂量，减少了大剂量联合应用时产生的不良反应。同时，本品两种药物的联合制剂，可以大大提高患者对治疗的依从性。在国外临床报道中，相比单独用药，联合用药能显著降低患者的血压，同时联合用药组患者的副作用发生率低于单独用药组患者，说明联合用药不仅比单独用药更能有效的控制患者的血压，并且还能更好地降低副反应的发生率。
包装规格[注：以下产品不同规格不同的价格，购买以咨询为准]
配合錠LD(8mg/2.5mg)
100錠（10錠×10）、140錠（14錠×10）、500錠（バラ、10錠×50）、700錠（14錠×50）、1,000錠（10錠×100）

配合錠HD(8mg/5mg)
100錠（10錠×10）、140錠（14錠×10）、500錠（バラ、10錠×50）、700錠（14錠×50）、1,000錠（10錠×100）

生产商
武田藥品工業株式会社
http://www.kegg.jp/medicus-bin/japic_med?japic_code=00058531
Brand Name：UNISIA Combination Tablets LD & HD Generic Name：Candesartan Cilexetil / Amlodipine Besilate Ingredients and Quantity：
UNISIA Combination Tablets LD :It contains 8mg of Candesartan Cilexetil and 2.5mg of Amlodipine
UNISIA Combination Tablets HD :It contains 8mg of Candesartan Cilexetil and 5mg of Amlodipine        
Dosage and Usage：
UNISIA is orally administered to adults once daily as
Candesartan Cilexetil / Amlodipine, 8mg/2.5mg or 8mg/5mg.
It is not able to be used for the first line treatment of
hypertension.
Indications:Hypertension
Product registration:Approved on April 16, 2010
-------------------------------------
Brand name : UNISIA Combination Tablets LD
　Active ingredient: Candesartan cilexetil
 Amlodipine besilate
　Dosage form: light yellow oval tablets, major axis 8.6 mm, minor axis 5.1 mm, thickness 3.0 mm
　Print on wrapping: （Face） ユニシアLD　272, （Back） ユニシアLD
-------------------------------------
Brand name : UNISIA Combination Tablets HD
　Active ingredient: Candesartan cilexetil
 Amlodipine besilate
　Dosage form: light red oval tablets, major axis 8.6 mm, minor axis 5.1 mm, thickness 3.0 mm
　Print on wrapping: （Face） ユニシアHD　273, （Back） ユニシアHD
Effects of this medicine
This medicine lowers blood pressure by reducing peripheral vascular resistance via antagonism against receptor for the pressor substance angiotensin II as well as via its action upon the calcium channel in the vascular smooth muscle.
Usually, used for treatment of hypertension.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you ever experienced any allergic reaction (itch, rash etc.) to any medicine.
If you have renal disorder, liver disorder, heart failure, hyperkalemia, or hyponatremia; are on hemodialysis, or on low-salt diet therapy; or in a preoperative state.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•For adults, take 1 tablet at a time, once a day. Strictly follow the instructions of your doctor/pharmacist.
•If you missed a dose, take the missed dose as soon as possible. If it is less than 8 hours to the next dose, skip the missed dose and then continue your regular dosing schedule. DO NOT take double doses to make up for the missed dose.
•If you took too much of the medicine (more than ordered), check with your doctor/pharmacist.
•Do not stop taking the medicine without the instructions of your doctor.
Precautions while taking this medicine
•As dizziness and light-headedness may appear due to excessive lowering of blood pressure, take extra care when working at heights or operating dangerous machinery such as driving a car.
•Do not take the medicine together with grapefruits juice.
Possible adverse reactions to this medicine
Common side effects are reported as below. If any of them occurs, check with your doctor/pharmacist: rash, itching, photosensitivity, angiitis, dizziness, light-headedness, dizziness on standing up, glow, fall in blood pressure, abdominal discomfort, enlarged feeling of the abdomen, diarrhea, cough, ear ringing, etc.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•swelling of face, tongue and throat, breathlessness [angioedema]
•feeling cold, vomiting, loss of consciousness [shock, syncope, loss of consciousness]
•decreased urinary output, swelling of face and hands/feet, fever [acute renal failure]
•numbness of hands/feet and lips, muscle weakness [hyperkalemia]
•yellowing of the skin or whites of the eyes, dullness, loss of appetite [liver dysfunction, jaundice]
•fever, sore throat, dullness [agranulocytosis, decreased white blood cell count]
•lassitude, muscle pain, brown urine [rhabdomyolysis]
•fever, dry cough, breathlessness [interstitial pneumonia]
•cold sweat, feeling hungry, tremor in hands [hypoglycemia]
•nose bleeding, gingival bleeding, subcutaneous bleeding [decreased platelet count]
•bradycardia, dizziness [atrioventricular block]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of children. Store away from direct sunlight, heat and humidity.
•Discard the remainder. Do not store them.
Takeda Chemical Industries, Ltd.Internal
Revised: 12/2010
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.