部份中文头孢他啶处方资料（仅供参考） 【中文品名】头孢他啶 【药效类别】抗生素>头孢菌素类 【通用药名】CEFTAZIDIME 【别　　名】噻甲羧肟头孢菌素, 头孢齐定, 复达欣, 凯复定, 头孢噻甲羧肟, Cefortam, Fortam, Fortaz, Fortum, Glazidim, Kefadim, Magnacef, Modacin, Panzid, Tazicef, Tazidime, Antibiotic GR-20263, Strarcef SN-401 【化学名称】 Pyridinium, 1-[[(6R,7R)-7-[[(2Z)-(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-en-3-yl]methyl]-, inner salt, pentahydrate 【CA登记号】[72558-82-8] 【结 构 式】 【分 子 式】C22H22N6O7S2 . 5H2O 【分 子 量】636.58 【收录药典】 【开发单位】Glaxo (英国) 【首次上市】1984年，英国 【性　　状】 白色或微黄色结晶性粉末，无臭或稍有特异臭味。易溶于二甲亚砜，几乎不溶于乙醚、乙酸乙酯、难溶于水，极难溶于乙醇。[α]D20=-30°(pH6磷酸缓冲液)。 【构效关系】 3-位、7-位酰胺基上侧链的改变，决定了该药的药代动力学特性、安全性和抗菌活性。在头孢甲肟的7-位亚氨甲氧基处连接羧异丙基，使该药具有较优的抗绿脓杆菌活性和对β-内酰胺酶的高度稳定性。同时却使CAZ对G+菌PBPs亲和力降低，所以对G+菌的抗菌活性不如头孢甲肟。3-位吡啶基使该药的蛋白结合率降低(17%)和仅有微量肾小管排泄。 【抗菌活性】 细菌对CAZ敏感性标准，当MIC≤8μg/ml时对CAZ敏感，MIC≥32μg/ml时对CAZ耐药(菌量接种104--106CFU)。 CAZ对假单孢菌和肠杆菌科细菌有较强的抗菌活性，其MIC范围为0.5--32μg/ml。其它第三代头孢菌素为2--128μg/ml。它对耐氨基糖甙类抗生素和耐羧苄青霉素的绿脓杆菌仍敏感(MIC90为1--4μg/ml)。CAZ对绿脓杆菌具有杀菌作用，对庆大霉素敏感的绿脓杆菌，其最小抑菌浓度(MIC)为8.5μg/ml。 【药代动力学及临床】 CAZ的药代动力学与第三代相似，静注或肌注给药1g，血药浓度比它对绿脓杆菌及肠杆菌科细菌的MIC值要高好几倍，并能维持6--8 h，血中半衰期近2 h，肾功能不全患者更长。本品不被代谢，不经肾小管分泌，由肾小球过滤排出。最初的24 h 约有给药量的80--90%由原尿中排出。临床上CAZ特别适合治疗由绿脓杆菌所引起的各种类型感染，一般情况下，单独用药比联合用药效果好。 【用　　途】 属第三代头孢菌素，主要抑制细菌细胞壁的合成，从而起杀菌作用，抗菌谱似头孢氨噻肟，对绿脓杆菌作用优于头孢磺苄和氨基糖甙类抗生素。绝大多数病原菌株，包括对氨基糖甙类、青霉类及其他头孢菌素耐药细菌对本品敏感，如金葡萄菌、表皮葡萄球菌、化脓性链球菌、肺炎杆菌及其他克雷白菌属、变形菌属、肠杆菌属、沙雷菌属、沙门菌属、志贺菌属、流感噬血杆菌、脑膜炎球菌、淋球菌等革兰氏阴性菌，消化球菌属和消化链球菌属、梭杆菌属、拟杆菌属等厌氧菌。肌注本品1g，1.3小时血药浓度峰值37ug／ml，静注lg，5分钟达87ug／ml。给药后，大多数组织的最小抑制浓度高于其他中枢神经系统。本品易通过胎盘，但很难透入正常的血脑屏障。t1／2约为 1.8小时。血清蛋白结合率约10％。24小时内约90％的药以原型通过肾小球滤过而随尿排出。 用于上述敏感菌引起的严重感染症：败血症、腹膜炎以及患血液病或恶性肿瘤的免疫抑制性病人合并的感染，也用于烧伤、呼吸系统、泌尿系统、耳鼻咽喉、皮肤和软组织以及胃肠道感染。临床上对老年和肾衰竭病人，可安全地替代氨基糖甙类。 モダシン静注用0.5g／モダシン静注用1g 治疗类别名称 头孢类抗生素制剂 中文药名：头孢他啶水合物 商標名 Modacin for injection 一般名 セフタジジム水和物（Ceftazidime Hydrate） 化学名 (6R,7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2-(1-carboxy-1-methylethoxyimino)acetylamino]-3-(pyridinium-1-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate pentahydrate 略号 CAZ 分子式 C22H22N6O7S2・5H2O 分子量 636.65 構造式 性状 它是白色结晶粉末，以淡黄白色。微溶于水，乙腈或乙醇（95）非常微溶。 分配系数 它不是用1-辛醇/水体系（pH 7.0）中分配到有机层中。 包装规格 静脉 0.5克  10瓶 1克    10瓶 制造商（进口） 葛兰素史克公司 完整处方资料附件：http://www.info.pmda.go.jp/go/pack/6132418F1041_1_05/ Modacin for Intravenous Infusion（Ceftazidime hydrate） Modacin for Intravenous Infusion 0.5g（モダシン静注用0.5g）  Brand name : Modacin for Intravenous Infusion 0.5g 　Active ingredient: Ceftazidime hydrate 　Dosage form: injection 　Print on wrapping: Modacin for Intravenous Infusion 1g（モダシン静注用1g）  Brand name : Modacin for Intravenous Infusion 1g 　Active ingredient: Ceftazidime hydrate 　Dosage form: injection 　Print on wrapping:  Effects of this medicine This medicine is a cephem antibiotic that exerts antibacterial effects by inhibiting bacterial cell wall synthesis and proliferation of bacteria. It is usually used to treat a wide range of infections. Before using this medicine, be sure to tell your doctor and pharmacist •If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines. If you or a member of your family has a predisposition for allergic symptoms, such as bronchial asthma, rash and hives. If you have renal disease. If you cannot eat or have poor health condition. •If you are pregnant or breastfeeding. •If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.) Dosing schedule (How to take this medicine) •Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>> •In general, inject this medicine intravenously 2 to 4 times a day according to your symptoms. This medicine may also be injected with an intravenous drip infusion. •This medicine is used for a certain period of time depending on the effects. Precautions while taking this medicine • Possible adverse reactions to this medicine The most commonly reported adverse reactions include abnormal liver function, rash, itch, fever, hives and erythema. If any of these symptoms occur, consult with your doctor or pharmacist. The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately. •facial pallor, cold sweat, dizziness on standing up [shock/anaphylactoid symptoms] •decreased urine output, edema, headache [serious renal disorder such as acute renal failure] •vulnerable to bruising, bleeding tendency, fever or chills [pancytopenia, agranulocytosis, hemolytic anemia, thrombocytopenia] •abdominal pain, diarrhea, loss of appetite [serious colitis accompanied by bloody stool such as pseudomembranous colitis] •fever, mucosal hyperemia of the eyes, mucosal eruption with pain in the oral mucosa [oculomucocutaneous syndrome/toxic epidermal necrosis] The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.