英文药名：CATALIN FOR OPHTHALMIC 0.005%(Pirenoxine)

中文药名：吡诺克辛眼科滴眼液

生产厂家：千寿製薬

カタリン点眼用0.005%

治疗类别名称
老年性白内障的治疗剂
一般名
ピレノキシン(Pirenoxine)〔JAN〕
化学名
1-Hydroxy-5-oxo-5H-pyrido［3,2-a］phenoxazine-3-carboxylic acid
構造式

分子式
C16H8N2O5
分子量
308.25
性状
吡诺克辛是黄棕色粉末，没有气味，味道微苦。
极微溶于二甲亚砜，水，乙腈，乙醇（95），并在四氢呋喃或乙醚中几乎不溶。
熔点：约250℃（分解）
操作注意事项
警告
这种药物，应引起注意，因为颜色是由金属离子的掺入改变。
药理毒理
研究表明，白内障形成的原因之一是由于晶体内可溶蛋白质受醌类物质作用，逐渐变成不溶性蛋白质所致。醌类物质系由体内重要功能氨基酸-色氨酸的异常代谢所形成。此种醌类物质对晶状体可溶蛋白质的作用可被卡塔琳竞争性抑制。另外，卡塔琳还可对抗自由基对晶状体损害而导致的白内障。因此，本品对白内障的发展具有一定的抑制功效。动物实验显示，卡塔琳能减少白内障囊外摘除术后后囊膜混浊的发生率。
适应症
初期老人性白内障
剂量和用法
滴眼一次1-2滴，每天滴眼3-5次
储存，到期日期等
存储等
具体请参考[处理]
截止日期
生产三年之后（见解体后的有效期限的部分[处理]）
包装规格
（一个片剂眼科溶液和溶解液15毫升）×10
（一个片剂眼科溶液和溶解液15毫升）×50

制造厂商
千寿药业有限公司
完整处方附件：http://www.info.pmda.go.jp/go/pack/1319706Q2039_1_04/
CATALIN FOR OPHTHALMIC 0.005%（カタリン点眼用0.005％） 
Brand name : CATALIN FOR OPHTHALMIC 0.005%
　Active ingredient: Pirenoxine
　Dosage form: orangish yellow tablet, clear and colorless solvent, after dissolution; clear and yellow ophthalmic solution, (solvent bottle) with large white cap and small brown cap
　Print on wrapping: 
Effects of this medicine
This medicine prevents water-soluble protein in the crystal lens from insolubilization so as to maintain transparency of the lens, and consequently suppresses progression of cataract.
It is usually used to control the progress of early senile cataract.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you wear contact lenses.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•Dissolve the tablet in the solvent just before use. In general, apply 1 to 2 drops at a time, 3 to 5 times daily. Strictly follow the instructions.
•Following the instruction attached in the box, drop the tablet in the solvent and dissolve it shaking well.
•Before using, wash your hands with soap and water. Then warm the bottle by hand for a while (when you apply the medicine right after taking from cold storage, it may drop successively caused by cold air expanding in the bottle). Remove the small brown cap only while keeping the large white cap tightly closed and apply the medicine not to touch the tip of eye dropper to any surface of your eye. After instilling, close your eyes and do not blink for a while. Wipe off any excess liquid with a clean gauze or tissue. If you need to use other eye drops at the same time, wait more than 5 minutes.
•If you miss a dose, apply a dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should not use two doses at one time.
•If you accidentally use more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop using this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
•Possible adverse reactions to this medicine
The most commonly reported adverse reactions include blepharitis (eyelid inflammation), contact dermatitis (rash in the area where the medicine is attached), diffuse superficial keratitis (foreign-body sensation, eye pain, sensitive to light, teary eye), conjunctival congestion, conjunctivitis, irritation in the eye, itching in the eye, foggy vision, eye discharge, lacrimation, eye pain, abnormal sensation in the eye and foreign-body sensation in the eye. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
No pertinent entries.
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of children. Store at room temperature (1-30℃), away from direct sunlight.
•After dissolution, store away from light in a cold place (1-15℃), and use within 3 weeks.
•Discard the remainder. Do not store them.
•To avoid improper use and quality loss, do not transfer this solution to any other bottle or container.
•Do not use any other solution in this bottle.
Senju Pharmaceutical Co.,Ltd.External
Revised: 12/2013
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.