英文药名：NEODOPASOL COMBINATION TABLETS（Levodopa/Benserazide Hydrochloride） 中文药名：左旋多巴/盐酸苄丝肼复方片 生产厂家：第一三共制药 ネオドパゾール配合錠 治疗类别名称 帕金森治疗药物 商標名 NEODOPASOL COMBINATION TABLETS 1.左旋多巴 (1) 一般名 レボドパ (Levodopa) (2) 略名 L-DOPA (3) 化学名 3-Hydroxy-L-tyrosine (4) 分子式 C9H11NO4 (5) 分子量 197.19 (6) 構造式 (7) 性状 白色或略带灰色色彩的白色结晶或结晶性粉末，没有异味。易溶于甲酸，微溶于水，并在乙醇中（95）几乎不溶。溶于稀盐酸。 饱和水溶液的pH值是5.0到6.5。 (8) 融点 约275℃（分解） 2.盐酸苄丝肼 (1) 一般名 ベンセラジド塩酸塩 (Benserazide Hydrochloride) (2) 化学名 (2RS )-2-Amino-3-hydroxy-N′-(2,3,4-trihydroxybenzyl)propanoylhydrazide monohydrochloride (3) 分子式 C10H15N3O5・HCl (4) 分子量 293.70 (5) 構造式 (6) 性状 是一种白色或类白色结晶性粉末。易溶于水或甲酸，略溶于甲醇，乙醇（95）非常微溶。易溶于0.1mol / L的盐酸测试解决方案。解决这个品1.0g溶解于100ml水的pH为4.0至5.0。它是吸湿性的。光逐渐着色。水溶液（1→100）示出了没有旋光性。 适应病症 帕金森氏病，帕金森氏综合症 用法用量 末用左旋多巴者 成人：日剂量1-3粒第一1-3次，逐渐由饭后口服给药的每日剂量为1-2片，每2-3天增加，每天1次3-6片剂作为维持剂量口服给药。此外，增加或减少取决于患者的年龄和症状。 用过左旋多巴者 成人：初始日剂量被切换到左旋多巴量（每片这种药物在左旋多巴100毫克含），它经口饭后给药在1-3分剂量，逐渐增加或逐渐下降，3至6片作为维持剂量的每日剂量口服施用。 此外，增加或减少取决于患者的年龄和症状。 药效药理 Neodopazoru组合片剂是左旋多巴和芳香族L-氨基酸脱羧酶抑制剂苄丝肼的4：帕金森治疗剂与1比例混合。患者帕金森氏病，帕金森氏综合征，具有补充该缺少在纹状体脑多巴胺的作用，以下动作已被实验在大鼠中观察到。 左旋多巴是多巴胺的前体，血 - 通过血脑屏障通过，在脑中转化为多巴胺由脱羧酶的作用，以改善帕金森氏病，帕金森氏综合症的症状。然而，在单次给药的情况下，左旋多巴在周边组织转化为快速多巴胺通过脱羧酶。因此在体内，血液中的吸收左旋多巴量相比 - 左旋多巴量通过血脑屏障掺入脑少5）。另一方面，苄丝肼盐酸盐为左旋多巴脱羧酶抑制剂，以防止左旋多巴脱羧在除脑以外的外围组织。因此，在外围制剂增加血左旋多巴水平，它增加左旋多巴过渡量到大脑6）。 相比左旋多巴单独施用，左旋多巴的每日剂量可以减少到大约五分之一，以发挥相同或更多的效果。 另外食欲不振，恶心的损失，缓解消化功能紊乱，如呕吐。此外，即使在组合盐酸吡哆醇（维生素B6）工作不衰减。 包装规格 组合片剂 （PTP）100粒（瓶装）1000片 制造厂商 第一三共有限公司 NEODOPASOL COMBINATION TABLETS（Levodopa/Benserazide Hydrochloride） Brand name : NEODOPASOL COMBINATION TABLETS 　Active ingredient: Levodopa   Benserazide hydrochloride 　Dosage form: pale red tablet with split line (diameter: 9.1 mm, thickness 3.2 mm) 　Print on wrapping: ネオドパゾール配合錠, Neodopasol , D119 Effects of this medicine This medicine enhances the transfer of levodopa into the brain by inhibition of amino-acid decarboxylase, and changes levodopa into dopamine to supplement insufficient dopamine, and consequently improves symptoms such as movement disorders in daily life, tremor of limbs, abnormal posture, muscle rigidity and slow movement associated with Parkinson's disease and parkinsonian syndrome. It is usually used for the treatment of Parkinson's disease and parkinsonian syndrome. Before using this medicine, be sure to tell your doctor and pharmacist •If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines. If you have angle-closure glaucoma. •If you are pregnant or breastfeeding. •If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.) Dosing schedule (How to take this medicine) •Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>> •If you have never taken levodopa before: In general, for adults, the initial dose is started at 1 to 3 tablets (100 to 300 mg of levodopa) daily, in 1 to 3 divided doses, after meal. The daily dose is increased by 1 to 2 tablets (100 to 200 mg) every 2 or 3 days, then take 3 to 6 tablets (300 to 600 mg) daily, as the maintenance dose. If you have been taking Levodopa: In general, for adults, the initial dose is determined based on equivalent to one fifth of levodopa (this preparation contains 100 mg of levodopa in a tablet) of the daily maintenance dose that you are taking, and take it in 1 to 3 divided doses daily, after meal. After that, the dosage may be adjusted, then take 3 to 6 tablets (300 to 600 mg) daily, as the maintenance dose. In any case, the dosage may be adjusted according to the age or symptoms. Strictly follow the instructions. •If you miss a dose, take a dose as soon as possible when you remember that you missed a dose. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time. •If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist. •Do not stop taking this medicine unless your doctor instructs you to do so. Precautions while taking this medicine •The medicine may cause sudden sleep or drowsiness; difficulty in seeing; decline of attention, concentration or reflection. Avoid driving a car or operating dangerous machinery after taking the medicine. Possible adverse reactions to this medicine The most commonly reported adverse reactions include involuntary movement, insomnia, hallucination, nausea, vomiting and loss of appetite. If any of these symptoms occur, consult with your doctor or pharmacist. The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately. •muscle rigidity, fever, impaired consciousness [neuroleptic malignant syndrome] •unconsciousness, difficulty in thinking, seeing things or hearing sounds that do not exist, depression, not feel like doing anything [confusion, hallucination, depression] •nausea, vomiting, epigastric pain [deterioration of gastric or duodenal ulcer] •light headness, yellowing of the skin/the white of eyes, fatiguability [hemolytic anemia, thrombopenia] •sudden drowsiness without any sign [sudden sleep] •severe eye pain, headache, sudden visual loss [angle-closure glaucoma] The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above. Storage conditions and other information •Keep out of the reach of children. Store away from light, heat and moisture (the medicine is hygroscopic). •Discard the remainder. Do not store them. •If you may have angle-closure glaucoma, take a gonioscopy or intraocular pressure test. •[To family members] Despite an unfavorable social outcome, the following symptoms may appear: repeated gambling, repeated excessive unplanned shopping, and an abnormal rise in sexual desire and appetite, etc. If any of these symptoms are observed, consult with your doctor. DAIICHI SANKYO COMPANY, LIMITEDInternal Revised: 4/2016 The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment. http://www.info.pmda.go.jp/go/pack/1169100F1060_1_10/1169100F1060_1_10?view=body