国外媒体报道，研究人员在2010欧洲抗风湿病联盟年会上说，类风湿性关节炎（RA）患者接受阿达木单抗治疗可诱导低疾病活动状态，并且疗效至少可维持4年。 研究人员回顾了一项为期12周标签公开3b期活动期风湿性关节炎(ReACT)实验的结果，这项实验纳入了6,610例RA患者。患者被确诊为类风湿关节炎约10-12年。约四分之三的患者接受了以前的疾病改善抗风湿治疗药的治疗。 研究发现，几乎在所有情况下，这些患者均对阿达木单抗治疗应答。例如首次接受肿瘤坏死因子拮抗剂治疗的患者，从3个月到12个月，完成1年的治疗并达到低疾病活动状态的比例从11.9％上升至31.8％。如果他们以前曾接受过生物制剂治疗，1年后达到低疾病活动状态的患者比例从10.9％增加21.9％。低疾病活动状态定义为28关节计数评分疾病活动性得分<=3.2。 德国柏林夏里特大学医学Burmester博士指出，如果患者已经接受英利昔单抗或依那西普并且DAS28得分在6至7范围内，切换到阿达木单抗治疗可以使病人的DAS28得分达到3至5的范围内——而且这个得分可维持超过4年。 Manufacturer: No Manufacturer Listed Description This medicine is a tumor necrosis factor (TNF) blocker used for treating a variety of moderate to severe inflammatory conditions (eg, rheumatoid arthritis, juvenile rheumatoid arthritis [JRA], psoriatic arthritis, ankylosing spondylitis). It is also used to treat certain patients with moderate to severe Crohn disease and certain patients with chronic plaque psoriasis. It may be used alone or in combination with other medicine. Directions STORE THIS MEDICINE in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Protect from light. Store in the original container until ready to use. Side Effects SIDE EFFECTS that may occur while taking this medicine include back pain; headache; mild pain, redness, or swelling at the injection site; nausea; sinus inflammation; or stomach pain. If they continue or are bothersome, check with your doctor. CONTACT YOUR DOCTOR IMMEDIATELY if you experience blood in the urine or stools; butterfly-shaped rash on the nose and cheeks; chest pain; fainting; fast or irregular heartbeat; mental or mood changes; muscle pain or weakness; new or worsening joint pain; numbness, tingling, or pain in the hands or feet; open sore that does not heal; persistent cough; persistent pain, swelling, or redness at the injection site; red, swollen, or blistered skin; severe or persistent headache or dizziness; severe or persistent stomach pain; shortness of breath; signs of infection (eg, fever, chills, or sore throat; warm, red, or painful skin); swelling of the ankles, hands, or feet; unexplained weight loss; unusual bruising or bleeding; unusual lumps; unusual tiredness or weakness; unusually pale skin; or vision changes. AN ALLERGIC REACTION to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; or unusual hoarseness.