药品名称: 普瑞巴林 [药代动力学]:在随机、安慰剂对照交叉临床试验中,29名健康志愿者接受pregabalin 1-300mg单次口服。Pregabalin吸收迅速,tmax在1.3小时内达到。Cmax和AUC 0-∞和给药剂量成正比,两者的范围分别为0.0383-9.46μg/ml和0.223-66.3μg x h-1xml-1。清除半衰期的范围为4.6-6.8h,和剂量无关。89.8%的给药剂量以原型形式从尿中排出[1]。 [不良反应]:一项双盲、安慰剂对照试验发现,165名局部发作型癫痫病人在原有治疗基础上加上pregabalin治疗(剂量为50、100、150、300和600 mg/day,每日两次)。最大剂量时大部分患者的耐受性良好。头晕和嗜睡是最常出现的不良反应,600mg/day剂量组的发生率最高,头晕发生率为42%,嗜睡的发生率为29%。而安慰剂组这两种不良反应的发生率均为11%。大部分不良反应为轻到中度。8名患者因不良反应退出了试验,这些患者均是300mg/day 和600mg/day剂量组的患者[2]。泛发型焦虑症和社交恐怖症患者所进行的临床试验也发现头晕和嗜睡是最常出现的不良反应[3] [4]。 [临床试验]:在2003年6月美国神经病学会议上,辉瑞公司公布的pregabalin试验数据表明,该药可以快速有效的治疗广泛性焦虑障碍(GAD)的各种症状。数据综合自5个安慰剂对照试验,包括II期临床试验和III期临床先导试验。数据表明pregabalin对GAD急性治疗的效果广泛、快速。Pregabalin在使用第一周就缓解了每个参加试验患者的精神和身体焦虑症状。在其中一个先导试验中,抗抑郁药文拉法新(venlafaxine)作为对照药物。与之相比pregabalin改善精神和躯体焦虑症状显著快,文拉法新没能在第一周就改善患者焦虑症状。在另一个先导试验中,以苯并二氮卓类药物阿普唑仑(alprazolam)为对照药品,数据再次显示pregabalin显著快速的改善精神和躯体焦虑症状,在第一周就有所改善,而阿普唑仑在第一周只改善了精神症状。2002年的一项双盲试验考察疱疹感染后神经痛患者服用300 mg、600mg pregabalin 8周后与安慰剂的差别,评价方式为平均疼痛得分和SF-McGill疼痛调查表(SF-MPQ)。治疗后第一周疗效就很明显,并且效果持续到研究结束。而另一个研究表明该药效果与剂量相关。在健康志愿者和肾功能不好的慢性疼痛患者中的药代动力学考察表明药物释放呈线性,两者的药物消除率与肌酐清除率有关,在同时服用口服胰岛素、利尿剂和抗糖尿病药物时不必调整该药剂量。 Monograph Number: 7813 LYRICA is not for everyone. LYRICA may cause serious allergic reactions. Tell your doctor right away about any serious allergic reaction such as swelling of the face, mouth, lips, gums, tongue or neck or if you have any trouble breathing. Other allergic reactions may include rash, hives and blisters. Tell your doctor about any changes in your eyesight, including blurry vision, muscle pain along with a fever or tired feeling, or skin sores due to diabetes. Some of the most common side effects of LYRICA are dizziness, sleepiness, weight gain, blurred vision, dry mouth, feeling "high", swelling of hands and feet, and trouble concentrating. You may have a higher chance for swelling and hives if you are also taking angiotensin converting enzyme (ACE) inhibitors so you should let your doctor know if you are taking these medications. You may have a higher chance of swelling or gaining weight if you are also taking certain diabetes medicines. You should not drive a car or operate machinery until you know how LYRICA affects you. Do not drink alcohol while on LYRICA. Be especially careful about medicines that make you sleepy. Also tell your doctor if you are planning to father a child. Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you have had a drug or alcohol problem, you may be more likely to misuse LYRICA. You should talk with your doctor before you stop taking LYRICA, or any other prescription medication. LYRICA is one of several treatment options for you and your doctor to consider. 单价(人民币 RMB): 1,868 元 |
序 号 | 药品名称 | 通用名称 | 规 格 | 单位 | 零售价(元) | 生 产 企 业 |
4891 | 普瑞巴林 | 普瑞巴林 | 75毫克x60胶囊 | 瓶 | 1868 | Pfizer Global Pharmaceuticals (辉瑞公司) |
4892 | Lyrica | 普瑞巴林 | 25毫克x90胶囊 | 瓶 | 1868 | Pfizer Global Pharmaceuticals (辉瑞公司) |