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当前位置:药品说明书与价格首页 >> 综合药讯 >> 曲司氯铵缓释胶囊-治疗尿失禁,膀胱过度活动症上市新药

曲司氯铵缓释胶囊-治疗尿失禁,膀胱过度活动症上市新药

2009-11-19 12:31:06  作者:新特药房  来源:中国新特药网  浏览次数:237  文字大小:【】【】【
简介: 用于膀胱过度活动症的曲司氯铵缓释胶囊在英国上市近日,英国上市了用于治疗膀胱过度活动症(OAB)的曲司氯铵(trospium chloride,Regurin)缓释胶囊,本品只需每日服用一次。其特点为起效快,可持续有效 ...
用于膀胱过度活动症的曲司氯铵缓释胶囊在英国上市

近日,英国上市了用于治疗膀胱过度活动症(OAB)的曲司氯铵(trospium chloride,Regurin)缓释胶囊,本品只需每日服用一次。其特点为起效快,可持续有效改善OAB的症状,中枢神经系统不良反应少。一项多中心临床Ⅲ期试验表明该药在使用后第一周末开始产生持续的疗效。本品是季胺类药物,具有阿托品样解痉效应。对M1和M3受体具有高亲合力,对M2受体的亲和力较弱。与其他OAB药物的不同点在于,该药不易代谢、与蛋白结合少以及理论上不能穿过血脑屏障及血眼屏障,因而与OAB治疗相关的不良反应相对较少。

How does it work?

Regurin tablets and Regurin XL prolonged release capsules both contain the active ingredient trospium chloride, which is a type of medicine called an anticholinergic (or antimuscarinic) muscle relaxant. It works by relaxing the involuntary muscle that is found in the wall of the bladder.

The muscle in the wall of the bladder is called the detrusor muscle. It can sometimes contract in uncontrollable spasms, and this is often referred to as having an overactive bladder. The overactive detrusor muscle can increase in the number of times you need to pass urine, or cause uncontrollable urges to pass urine, or involuntary leakage of urine (urinary incontinence).

Trospium works by relaxing the detrusor muscle in the wall of the bladder. It does this by blocking receptors called cholinergic (or muscarinic) receptors that are found on the surface of the muscle cells. This prevents a natural body chemical called acetylcholine from acting on these receptors.

Normally when acetylcholine acts on these receptors, it causes the detrusor muscle to contract and the bladder to empty. By blocking acetylcholine, trospium helps the muscle in the bladder wall to relax. This reduces unstable, involuntary contractions of the bladder, and thereby increases the capacity of the bladder to hold urine. In turn, this reduces the need to pass urine.

Regurin tablets are known as an immediate release dose form. This means that the medicine is absorbed into the bloodstream from the gut soon after the tablets are taken. These tablets are taken twice a day.

Regurin XL capsules are known as prolonged release capsules. They are designed to release the medicine slowly over the day as the capsule passes through the gut. This means the capsule only need to be taken once a day. The capsules should be swallowed whole with liquid and not chewed or crushed, as this would stop their prolonged release action from working.

What is it used for?

  • Increased need to pass urine (urinary frequency), uncontrollable urges to pass urine (urinary urgency) and involuntary leakage of urine (urinary incontinence) due to an overactive bladder .

Warning!

  • This medicine may cause blurred vision and so may affect your ability to drive or operate machinery safely. Do not drive or operate machinary until you know how this medicine affects you.
  • Your doctor should reassess whether you still need treatment with this medicine every three to six months.

Use with caution in

  • Obstruction or decreased motility of the stomach or intestines, such as pyloric stenosis.
  • Obstruction of the outflow of urine from the bladder.
  • Disorder of the involuntary nerves that control the internal organs (autonomic neuropathy).
  • Hiatus hernia associated with reflux oesophagitis.
  • Heart diseases, for example angina, heart failure, irregular heart beats (arrhythmias).
  • Hyperthyroidism.
  • Decreased liver function.
  • Decreased kidney function.

Not to be used in

  • Inability to pass urine (urinary retention).
  • Closed angle glaucoma..
  • Abnormal muscle weakness (myasthenia gravis).
  • Severe inflammation of the bowel and back passage (ulcerative colitis).
  • Sudden expansion of the large intestine seen in advanced ulcerative colitis or Crohn's disease (toxic megacolon).
  • Fast, abnormal heart rhythms (tachyarrhythmias).
  • There is insufficient information regarding the safety and efficacy of this medicine in children. Regurin tablets are not recommended for children under 12 years old. Regurin XL capsules are not recommended for children under 18 years old.
  • People with lactose intolerance, glucose/galactose malabsorption or a genetic disorder leading to accumulation of galactose in the blood (galactosaemia). (Regurin tablets contain lactose).
  • People who suffer from an allergy to wheat. (Regurin tablets contain wheat starch).
  • People with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption, or sucrose-isomaltase insufficiency. (Regurin tablets and Regurin XL capsules both contain sucrose).

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

  • The safety of this medicine in pregnancy has not been established. It should therefore be used with caution during pregnancy, and only if the benefits to the mother outweigh any risks to the foetus. Seek medical advice from your doctor.
  • It is not known if this medicine passes into breast milk. It should be used with caution in nursing mothers, and only if the benefits to the mother outweigh any risks to the nursing infant. Discuss this with your doctor.

Label warnings

  • Take this medication an hour before food or on an empty stomach.

Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

Very common (affect more than 1 in 10 people)

  • Dry mouth.

Common (affect between 1 in 10 and 1 in 100 people)

  • Dry eyes and nose.
  • Indigestion (dyspepsia) .
  • Abdominal pain and bloating.
  • Constipation.
  • Nausea.

Uncommon (affect between 1 in 100 and 1 in 1000 people)

  • Excess gas in the stomach and intestines (flatulence).

Rare (affect between 1 in 1000 and 1 in 10,000 people)

  • Difficulty in emptying the bladder.
  • Difficulty in passing urine (urinary retention) .
  • Increased heart rate (tachycardia).
  • Visual disturbances, such as blurred vision, difficulty focusing on near objects.
  • Diarrhoea.
  • Difficulty in breathing (dyspnoea).
  • Rash.
  • Weakness or loss of strength (asthenia).
  • Chest pain.

Very rare (affect less than 1 in 10,000 people)

  • Abnormal heart beats (arrhythmias).
  • Swelling of the legs and ankles due to excess fluid retention (peripheral oedema).
  • Headache.

The side effects listed above may not include all of the side effects reported by the medicine's manufacturer.

For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?

It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, ask your doctor or pharmacist before taking any new medicines while taking this one, so they can check that the combination is safe.

There may be an increased risk of side effects such as dry mouth, blurred vision, drowsiness, constipation and difficulty passing urine, if this medicine is taken with other medicines that have anticholinergic effects, such as the following:

  • amantadine
  • anticholinergic medicines for Parkinson's symptoms, eg procyclidine, orphenadrine, trihexiphenidyl (benzhexol)
  • antihistamines, eg brompheniramine, chlorphenamine
  • antipsychotic medicines, eg haloperidol, chlorpromazine, clozapine
  • antispasmodic medicines, eg hyoscine, atropine
  • disopyramide
  • other anticholinergic medicines for urinary incontinence, eg tolterodine, solifenacin, propiverine
  • MAOI antidepressants, eg phenelzine, tranylcypromine
  • tricyclic antidepressants, eg amitriptyline, clomipramine.

If you experience a dry mouth as a side effect of this medicine you may find that medicines that are designed to dissolve and be absorbed from under the tongue, eg sublingual glyceryl trinitrate (GTN) tablets, become less effective. This is because the tablets do not dissolve properly in a dry mouth. To resolve this, drink a mouthful of water before taking sublingual tablets.

This medicine may reduce the effects of the following medicines on the gut:

  • cisapride
  • domperidone
  • metoclopramide.

Trospium may enhance the increased heart rate that may be experienced after taking beta-sympathomimetic medicines such as the following:

  • adrenaline
  • certain medicines for asthma, eg salbutamol, terbutaline, salmeterol
  • decongestant medicines, eg ephedrine, pseudoephedrine, phenylpropanolamine.

The following medicines may reduce the absorption of trospium from the gut and should therefore not be taken together:

  • guar gum
  • colestyramine
  • colestipol.

Other medicines containing the same active ingredient

There are currently no other medicines available in the UK that contain trospium chloride as the active ingredient.

责任编辑:admin


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