| Famciclovir（Famvir）泛昔洛韦 [功效主治]：用于治疗带状疱疹和原发性生殖器疱疹。 [用法用量]：口服，成人一次0.25g，每8小时1次。治疗带状疱疹的疗程为7日，治疗原发性生殖器疱疹的疗程为5天。肾功能不全患者应根据肾功能状况调整剂量，推荐剂量如下：肌酐清除率剂量≥60ml/分钟成人一次0.25g，每8小时1次40～59ml/分钟成人一次0.25g，每12小时1次20～39ml/分钟成人一次0.25g，每24小时1次<20ml/分钟成人一次0.125g，每48小时1次 [不良反应]：常见不良反应是头痛和恶心，，此外尚可见下列反应：1.神经系统：头晕、失眠、嗜睡、感觉异常等。2.消化系统：腹泻、腹痛、消化不良、厌食、呕吐、便秘、胀气等。3.全身反应：疲劳、疼痛、发热、寒颤等4.其他反应：皮疹、皮肤瘙痒、鼻窦炎、咽炎等。 新的带状疱疹治疗剂：Famciclovir（Famvir） 7月28日诺华公司宣布，FDA已经批准其处方药Famvir（泛昔洛韦，famciclovir）片剂作为单日疗法用于免疫力正常的复发型生殖器疱疹（RGH）患者。Famvir可显著降低愈合时间，并减少症状。此外，FDA还批准Famvir作为单剂量疗法用于治疗免疫力正常的复发型口唇疱疹患者。 与其他抗病毒药物联合应用治疗HBV感染的也有报道。Kruger[155]报道用泛昔洛韦和α-2b干扰素联合治疗了1例患乙型肝炎相关性结节性多动脉炎的56岁男性患者，获得成功。Piqueras等[156]报道用泛昔洛韦+干扰素成功治疗1例慢性乙型肝炎患者的肝衰竭。Marques等[157]用泛昔洛韦加α干扰素对5例以前用干扰素治疗失败的成人慢性HBV感染者治疗了20周。治疗方法是：先用泛昔洛韦治疗4周，再加用α干扰素治疗12周，最后停用干扰素，继续使用泛昔洛韦治疗4周。结果有2例患者的HBV DNA阴转，肝功能和肝脏组织学改善。侯金林等[120]在拉米夫定和拉米夫定+泛昔洛韦治疗期间HBV动态改变的研究中也同样证实，联合治疗可提高拉米夫定的抗病毒疗效。 尽管对泛昔洛韦的研究早于拉米夫定，但近年来用其治疗乙型肝炎的报道远远低于拉米夫定。其原因主要是因为其抗HBV作用低于拉米夫定，且同样可诱导HBV多聚酶的YMDD耐药性变异，而治疗费用高于拉米夫定。 Seehofer等[72]对1988年-1998年间的179例肝移植后复发性HBV感染的治疗进行了回顾性的分析，比较了使用泛昔洛韦或拉米夫定+乙型肝炎免疫球蛋白治疗肝移植后复发性HBV感染的疗效，发现泛昔洛韦的疗效低于拉米夫定，且使用泛昔洛韦治疗后出现耐药的患者使用拉米夫定治疗仍然有效。Rayes等[10]对肝移植后长期应用泛昔洛韦和拉米夫定(20例)治疗乙型肝炎进行了比较性研究。32例患者使用泛昔洛韦治疗，20例患者使用拉米夫定治疗，7例患者在泛昔洛韦治疗失败后再用拉米夫定治疗。结果19例用泛昔洛韦治疗的患者和76%用拉米夫定治疗的患者HBV DNA阴转；用拉米夫定治疗的患者中有24%的患者HBsAg阴转，而用泛昔洛韦治疗的患者中无1例HBsAg阴转。对泛昔洛韦治疗失败的患者，拉米夫定治疗也是有效的。作者认为，拉米夫定的抗病毒效应比泛昔洛韦强。 最近，Berenguer等[158]报道了6例肝移植后的HBV感染者(HBsAg阳性，HBV DNA阳性，其中4例HBeAg阳性)用泛昔洛韦500mg tid治疗了至少12个月。结果无1例患者完全有效。有3例患者的ALT接近正常，无1例患者出现抗-HBs或抗-HBe的血清转换。2例患者的HBV DNA阴转，1例下降，其余3例甚至比治疗前DNA水平升高。仅1例患者治疗后肝脏组织学改善。因此作者认为，单独应用泛昔洛韦治疗肝移植后的HBV感染疗效欠佳。 在泛昔洛韦的Ⅲ期临床实验中，证实泛昔洛韦是一种强有力的抗HBV药物，但同时也发现长期应用后同样可以导致HBV多聚酶的YMDD基序变异。动物试验结果还证实，HBV对拉米夫定与泛昔洛韦有交叉耐药性。Mutimer[43]证实，在对拉米夫定耐药的两种变异株中，M550V-L526M与泛昔洛韦有交叉耐药性，而M550I与泛昔洛韦无关。据Rayes等[10]报道，长期治疗的患者中拉米夫定的耐药率为55%，而泛昔洛韦为80%。
【原产地英文商品名】FAMVIR 500mg/tab 30tabs/bottle
Famvir What is Famvir? Famvir is used to treat infections caused by herpes viruses. Illnesses caused by herpes viruses include genital herpes, cold sores, shingles, and chicken pox. -------------------------------------------------------- Important information about Famvir Treatment with Famvir should be started as soon as possible after the first appearance of symptoms (such as tingling, burning, blisters). Herpes infections are contagious and you can infect other people, even while you are being treated with Famvir. Avoid letting infected areas come into contact with other people. Avoid touching an infected area and then touching your eyes. Wash your hands frequently to prevent passing the infection to others. -------------------------------------------------------- Before taking Famvir If you have any of these conditions, you may need a dose adjustment or special tests to safely take Famvir. FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether Famvir passes into breast milk, or if it could harm a nursing baby. Do not take this medication without telling your doctor if you are breast-feeding a baby. Do not give this medication to a child younger than 18 years old. -------------------------------------------------------- How should I take Famvir? Treatment with Famvir should be started as soon as possible after the first appearance of symptoms (such as tingling, burning, blisters). Take each dose with a full glass of water. Drink plenty of water while you are taking this medication to keep your kidneys working properly. Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Famvir will not treat a viral infection such as the common cold or flu. Lesions caused by herpes viruses should be kept as clean and dry as possible. Wearing loose clothing may help to prevent irritation of the lesions. Store this medication at room temperature away from moisture and heat. -------------------------------------------------------- What happens if I miss a dose? -------------------------------------------------------- What happens if I overdose? -------------------------------------------------------- What should I avoid while taking Famvir? Famvir will not prevent the spread of genital herpes. Avoid sexual intercourse or use a latex condom to prevent spreading the virus to others. -------------------------------------------------------- Famvir side effects This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088. -------------------------------------------------------- What other drugs will affect Famvir? This list is not complete and there may be other drugs that can interact with Famvir. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. -------------------------------------------------------- Where can I get more information? Famvir 125 mg - white, round, film-coated tablets Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. |
泛昔洛韦片|FAMVIR（FAMCICLOVIR）简介：
Famciclovir（Famvir）泛昔洛韦[功效主治]：用于治疗带状疱疹和原发性生殖器疱疹。
[用法用量]：口服，成人一次0.25g，每8小时1次。治疗带状疱疹的疗程为7日，治疗原发性生殖器疱疹的疗程为5天。肾功能 ... 责任编辑：admin |
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