英文名：Oxiracetam

性状：又名奥拉酰胺，脑复智。为白色微晶状粉末，熔点165～168℃。由4-羟基吡咯啶-2-酮为原料制得。为脑代谢功能改善剂，属吡咯酮类化合物。可促进磷酰胆碱和磷酰乙醇胺的合成，促进脑代谢，能透过血脑屏障对特异性中枢神经通路产生刺激作用，可促进智力，改善记忆力。适用于大脑功能不全，记忆力衰退的老年患者，尤其适用于老年性痴呆症，还可用于治疗神经官能症、脑外伤、脑炎等脑部疾病的康复期治疗。制剂有片剂，胶囊，针剂。本品的毒性比较小。

药理作用：环GABOB衍生物。动物实验证实本品对化学物质所致学习记忆障碍有显著改善作用和促进学习记忆作用.本品毒性极低，小鼠灌胃给10g/kg，静注给药2g/kg和大鼠灌胃给药10g/kg均未见动物死亡，也未见毒性反应。文献报道，大鼠口服120mg/kg52、狗口服83.3mg/kg52周，也未见药物毒性反应.无致突变和致癌作用以及生殖毒性.

药代动力学：口服吸收迅速，入血后能迅速分布到全身体液.达峰时间（Tp）为1小时左右，峰浓度为48.34±18.35～54.96±34.73μg/ml，表观分布容积V/F（C）为27.45±21.16～36.18±28.73L，消除半衰期t1/2β为3.34±1.59～4.74±1.41小时，总清除率Cl(s)为6.78±5.50～11.65±5.40L/h，药物消除较迅速.服药后48小时内约40%的原形药经尿中排出.老年组和青年组排泄率常数分别为0.1098±0.0306和0.1295±0.0390h-1:消除半衰期t1/2分别为6.76±1.98和5.88±1.99小时，本品在不同年龄的正常人体内的消除规律基本一致。

适应症：一种促智药，适用于轻中度血管性痴呆、老年性痴呆以及脑外伤等症引起的记忆与智能障碍。

用法与用量：口服.一次800mg，一日2～3次，或遵医嘱适当增减。

不良反应：在327例Ⅱ期临床试验中未发现明显不良反应。

禁忌症：经证实对本品过敏者.肾功能不全者禁用。

注意事项：肾功能不全者，使用本品时要十分谨慎，并要降低剂量。

【原产地英文商品名】Oxiracetam 800mg/capsule 30capsules/bottle
【原产地英文药品名】Oxiracetam
【中文参考商品译名】
注：以下产品不同规格和不规格，购买时请以电话为咨询为准
·奥拉西坦 800毫克/胶囊 30胶囊/瓶
·奥拉西坦 800毫克/胶囊 60胶囊/瓶
·奥拉西坦 750毫克/胶囊 30胶囊/瓶
【中文参考药品译名】奥拉西坦
【生产厂家中文参考译名】NutraceuticsRx
【生产厂家英文名】NutraceuticsRx

NutraceuticsRX Oxiracetam
4-hydroxy-2-oxo-1-pyrrolidinacetamide.
A potent nootropic supplement of the racetam family.

It is a fast acting water soluble analog of the nootropic Piracetam. It is similar to, but far stronger than piracetam and aniracetam. Researchers wrote that oxiracetam is a "vigilance-enhancing compound with some effects on spontaneous memory", and that "in comparison with piracetam, oxiracetam exhibits a greater improvement in memory factor". During another study, they found that oxiracetam had better therapeutic results than piracetam on both a psychosomatic and neurologic symptoms. Oxiracetam also seemed to decease platelet aggregation.

Supplement Facts
Serving Size: 1 Capsule
Servings per container: 30
Amount Per Serving % Daily Value
Oxiracetam (4-hydroxy-2-oxo-1-pyrrolidinacetamide) 800 mg

Other Ingredients: Cellulose (capsule), and Rice flour.

Contains no: Wheat, yeast, gluten, corn, soy, milk, eggs, artificial colors or preservatives.

Suggested Use: As a dietary supplement take 1 capsule 2 - 3 times daily on an empty stomach. Or as directed by a health-care professional.

What works best with it? Piracetam, Aniracetam, Deprenyl, Hydergine, Centrophenoxine, L-Huperzine A, Idebenone, Pyritinol.

Oxiracetam is a nootropic drug of the racetam family.

Several animal studies suggest that the substance is safe even when high doses are consumed for a long period of time. However the mechanism of action of oxiracetam is still a matter of research.