|
英文药名: Oxytrol(Oxybutynin Patches)
中文药名: 奥昔布宁贴
生产厂家: Paladin
药品简介
奥昔布宁透皮贴剂(oxybutynin，Oxytrol)是透过皮肤将药物传输入血的一种贴片。由于该产品在治疗中是贴于患者腹部、髋部、臀部进行治疗，不用经过胃肠道系统，可避免其他常用尿失禁药物引起的不良反应如口干、便秘等。该贴剂本身不良反应，例如瘙痒等皮肤刺激。
同之前的口服药物相比，奥昔布宁透皮贴剂既具备抗胆碱药物的治疗优势，又可以避免或减少不良反应的发生，尤其对于一些老年患者来说更是不无裨益。这些患者一直以来服用片剂进行治疗，导致给药负担已经很重，而透皮贴剂的开发不仅提供了新的治疗途径和选择，还能为患者减轻治疗压力。
奥昔布宁透皮系统(Oxybutynin Transdermal System，Oxytrol)由美国Watson公司研制开发, Oxytrol系一透明柔软的薄贴片，1周1～2次贴于腹部、髋部或臀部。本品中的主要成分是奥昔布宁，该药口服制剂25年以来已被人们广泛接受和处方用药。Oxytrol透皮释药系统每日恒速释药3.9mg持续通过皮肤将药物释至全身血液循环，避免口服制剂的肝脏和胃肠道首过代谢，解除膀胱活动过度症状长达4日。
包装规格：
36mg 1盒 x 8 贴
36mg 3盒 x 8 贴
 |
Drug Uses
Oxytrol is indicated for the relief of symptoms of urinary incontinence, urgency and frequency in the unstable bladder, whether due to neurogenic bladder disorders (detrusor hyperreflexia) in conditions such as multiple sclerosis and spina bifida, or to idiopathic detrusor instability (motor urge incontinence).
Children over 5 years of age: In addition to neurogenic bladder disorders, Oxytrol may also be used in nocturnal enuresis in conjunction with non-drug therapy where this alone, or in conjunction with other drug treatment, has failed.
How to use
Adults: The usual dose is 5mg two or three times a day. This may be increased to a maximum of 5 mg four times a day to obtain a clinical response provided that the side effects are tolerated.
Elderly (including frail elderly): The elimination half-life is increased in the elderly. Therefore, a dose of 2.5mg twice a day, particularly if the patient is frail, is likely to be adequate. This dose may be titrated upwards to 5mg two times a day to obtain a clinical response provided the side effects are well tolerated.
Children (under 5 years of age): Not recommended.
Children (over 5 years of age): Neurogenic bladder instability: the usual dose is 2.5mg twice a day. This dose may be titrated upwards to 5mg two or three times a day to obtain a clinical response provided the side effects are well tolerated. Nocturnal enuresis: the usual dose is 2.5mg twice a day. This dose may be titrated upwards to 5mg two or three times a day to obtain a clinical response provided the side effects are tolerated. The last dose should be given before bedtime.
Drug Class and Mechanism
Oxytrol is an anticholinergic. It works by relaxing muscles in the bladder.
Missed Dose
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.
Storage
Store this medicine at room temperature in a tightly-closed container, away from heat and light.
Warnings/Precautions
Hypersensitivity to oxybutynin or any component.
Myasthenia gravis.
Narrow-angle glaucoma or shallow anterior chamber.
Gastrointestinal obstruction including paralytic ileus, intestinal atony.
Patients with toxic megacolon, severe ulcerative colitis.
Patients with bladder outflow obstruction where urinary retention may be precipitated.
Possible Side Effects
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Blurred vision; constipation; diarrhea; dizziness; drowsiness; dry eyes, nose, skin, or mouth; headache; indigestion; nausea; minor redness, itching, or irritation at patch application site; stomach pain.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; difficult or painful urination; fast or irregular heartbeat; fever; hallucinations; pain, burning, blistering, or oozing at the application site; seizures; swelling of the hands, ankles, or feet; vision problems.
More Information
If you have any questions about Oxytrol, please talk with your doctor, pharmacist, or other health care provider.
Oxytrol is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.
|
