英文药名: Fosamax(Alendronate Tablets)
中文药名: 福善美（阿仑膦酸钠片）
品牌药生产厂家: Merck Frosst
药品名称和成分
阿仑膦酸钠片
【英文名】Alendronate Sodium Tablets
【成份】阿仑膦酸钠
【性状】白色片
药理毒理
阿仑膦酸钠为氨基二膦酸盐骨吸收抑制剂,与骨内羟磷灰石有强亲和力。本品是通过抑制破骨细胞的活性而发挥抗骨吸收作用。其特点是抗骨吸收活性强,无骨矿化抑制作用。
适应症
适应于治疗绝经后妇女的骨质疏松症。
用法用量
口服,每日早餐前至少30分钟空腹用200ml温开水送服,一次10mg,一日1次。
如果您有任何疑问，请遵医嘱。
不良反应
服用后耐受性良好,少数病人可见胃肠道反应,如恶心、腹胀、腹痛等,偶有头痛、骨胳肌痉痛等,罕见皮疹或红斑。
禁忌
1 对本品过敏者禁用。
2 低钙血症患者禁用。
3 孕妇、哺乳期妇女禁用。
注意事项
1 早餐前至少30分钟用200ml温开水送服,用药后至少30分钟方可进食。
2 与桔子汁和咖啡同时服用会显著地减少本品的吸收。
3 在服用本品前后30分钟内不宜饮用牛奶、奶制品和含较高钙的饮料。
4 服药后即卧床有可能引起食道刺激或溃疡性食管炎。
5 胃肠道紊乱、胃炎、食道不适、十二指肠炎、溃疡病患者慎用。
6 婴幼儿、青少年不宜服用。
7 中、重度肾功能不全患者不宜服用。
8 开始使用本品治疗前,必须治愈钙代谢和矿物质代谢紊乱、维生素D缺乏及低钙血症。
9 补钙剂、抗酸剂和一些口服药剂很可能妨碍本品的吸收,因此,服用本品后应至少推迟半小时再服用其它药物。
10 男性骨质疏松症用药的安全性和有效性尚未验证,不推荐使用。
贮藏
密闭保存。
Boniva
Generic Name: ibandronate (eye BAN dro nate)
Brand Names: Boniva
What is Boniva?
Boniva (ibandronate) is in the group of medicines called bisphosphonates (bis FOS fo nayts). It alters the cycle of bone formation
and breakdown in the body. Ibandronate slows bone loss while increasing bone mass, which may prevent bone fractures.
Boniva is used to treat or prevent osteoporosis in women after menopause.
Boniva may also be used for other purposes not listed in this medication guide.
Important information about Boniva
Do not take a Boniva tablet if you cannot sit upright or stand for at least one full hour. Boniva can cause serious problems in the
stomach or esophagus (the tube that connects your mouth and stomach). You will need to stay upright for at least 60 minutes after
taking this medication.
Take the Boniva tablet first thing in the morning, at least 1 hour (60 minutes) before you eat or drink anything or take any other
medicine.
Take each dose with a full glass (6 to 8 ounces) of water. Use only plain water (not mineral water) when taking a Boniva tablet.
For at least the first 60 minutes after taking a Boniva tablet, do not lie down or recline; do not eat or drink anything other than
plain water; and do not take any other medicines including vitamins, calcium, or antacids.
Some people using medicines similar to Boniva have developed bone loss in the jaw, also called osteonecrosis of the jaw. Symptoms
of this condition may include jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery
involving the gums. You may be more likely to develop osteonecrosis of the jaw if you have cancer or have been treated with
chemotherapy, radiation, or steroids. Other conditions associated with osteonecrosis of the jaw include blood clotting disorders,
anemia (low red blood cells), and pre-existing dental problems.
Boniva is only part of a complete program of treatment that may also include diet changes, exercise, and taking calcium and vitamin
supplements. Follow your diet, medication, and exercise routines very closely.
Before using Boniva
You should not use Boniva if you are allergic to ibandronate, or if you have severe kidney disease, low blood levels of calcium
(hypocalcemia), or a problem with your esophagus (the tube that connects your mouth and stomach).
Do not take a Boniva tablet if you cannot sit upright or stand for at least one full hour. Boniva can cause serious problems in the
stomach or esophagus. You will need to stay upright for at least 60 minutes after taking this medication.
To make sure you can safely take Boniva, tell your doctor if you have any of these other conditions:
• a vitamin D deficiency;
• kidney disease;
• an ulcer in your stomach or esophagus; or
• trouble swallowing.
Some people using medicines similar to Boniva have developed bone loss in the jaw, also called osteonecrosis of the jaw. Symptoms
of this condition may include jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery
involving the gums.
You may be more likely to develop osteonecrosis of the jaw if you have cancer or have been treated with chemotherapy, radiation, or
steroids. Other conditions associated with osteonecrosis of the jaw include blood clotting disorders, anemia (low red blood cells),
and dental surgery or pre-existing dental problems.
FDA pregnancy category C. It is not known whether Boniva will harm an unborn baby. Tell your doctor if you are pregnant or plan to
become pregnant while using this medication. It is not known whether ibandronate passes into breast milk or if it could harm a
nursing baby. Do not use Boniva without telling your doctor if you are breast-feeding a baby.
How should I use Boniva?
Use Boniva exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the
directions on your prescription label.
Boniva tablets are taken either once each day or once each month. Boniva intravenous solution is given as an injection into one of
your veins once every three (3) months. A healthcare provider will give you this injection. Boniva tablets can be taken at home.
Take the Boniva tablet first thing in the morning, at least 1 hour (60 minutes) before you eat or drink anything or take any other
medicine. If you take a Boniva tablet only once a month, take it on the same day each month and always first thing in the morning.
Take each Boniva tablet with a full glass (6 to 8 ounces) of water. Use only plain water (not mineral water) when taking a Boniva
tablet. Do not crush, chew, or suck the tablet. Swallow the tablet whole.
After taking a Boniva tablet, carefully follow these instructions:
• Do not lie down or recline for at least 60 minutes after taking the tablet.
• Do not eat or drink anything other than plain water.
• Do not take any other medicines including vitamins, calcium, or antacids for at least 60 minutes after taking Boniva. It
may be best to take your other medicines at a different time of the day. Talk with your doctor about the best dosing schedule for
your other medicines.
To be sure this medication is helping your condition, your bone mineral density will need to be tested often. Visit your doctor
regularly.
Boniva is only part of a complete program of treatment that may also include diet changes, exercise, and taking calcium and vitamin
supplements. Follow your diet, medication, and exercise routines very closely.
Store Boniva tablets at room temperature away from moisture and heat.
What happens if I miss a dose?
If you take Boniva tablets once daily: If you forget to take this medicine first thing in the morning, do not take it later in the
day. Wait until the following morning to take the medicine and skip the missed dose. Do not take two (2) tablets in one day.
If you take Boniva tablets once a month: If you forget to take Boniva on your scheduled day, take it first thing in the morning on
the day after you remember the missed dose. Then return to your regular monthly schedule on your chosen dose day. If your next
scheduled dose is less than 7 days away, wait until then to take the medicine and skip the missed dose. Do not take two (2) tablets
in one week.
If you receive Boniva injections every 3 months: Call your doctor for instructions if you miss an appointment for your injection.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Drink a full glass of milk and call your local
poison control center or emergency room right away. Do not make yourself vomit and do not lie down.
Overdose symptoms may include nausea, heartburn, stomach pain, diarrhea, muscle cramps, numbness or tingling, tight muscles in your
face, seizure (convulsions), irritability, and unusual thoughts or behavior.
What should I avoid while taking Boniva?
Do not take any other medicines including vitamins, calcium, or antacids for at least 60 minutes before or after taking a Boniva
tablet. Avoid milk and other dairy products for at least 60 minutes after taking Boniva (except in the case of overdose as stated
above). Do not lie down for at least 1 hour (60 minutes) after you take a tablet.
Boniva side effects
Get emergency medical help if you have any of these signs of an allergic reaction to Boniva: hives; difficulty breathing; swelling
of your face, lips, tongue, or throat. Stop using Boniva and call your doctor at once if you have any of these serious side
effects:
• chest pain;
• difficulty or pain when swallowing;
• pain or burning under the ribs or in the back;
• new or worsening heartburn;
• severe joint, bone, or muscle pain; or
• jaw pain, numbness, or swelling.
Less serious Boniva side effects may include:
• back pain, headache;
• redness or swelling of your eyes;
• diarrhea;
• flu symptoms;
• redness or swelling where the medicine was injected;
• nausea or upset stomach; or
• pain in your arms or legs.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may
report side effects to FDA at 1-800-FDA-1088.
See also: Boniva side effects (in more detail)
What other drugs will affect Boniva?
Tell your doctor about all other medicines you use, especially aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such
as:
• celecoxib (Celebrex);
• diclofenac (Voltaren);
• diflunisal (Dolobid);
• ibuprofen (Motrin, Advil);
• indomethacin (Indocin);
• ketoprofen (Orudis)
• ketorolac (Toradol);
• naproxen (Aleve, Naprosyn); or
• piroxicam (Feldene), and others.
This list is not complete and other drugs may interact with Boniva. Tell your doctor about all medications you use. This includes
prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Where can I get more information?
• Your pharmacist can provide more information about Boniva.
• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use
this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-
date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum
information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not
warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information
does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to
assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a
supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a
warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe,
effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered
with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses,
directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs
you are taking, check with your doctor, nurse or pharmacist.
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产地国家：美国
原产地英文药品名：
ALENDRONATE SODIUM/CHOLECALCIFEROL
中文参考药品译名：
阿仑膦酸钠/维生素D3
原产地英文商品名：
FOSAMAX PLUS D(ALENDRONATE SODIUM/CHOLECALCIFEROL))70 MG/5600IU X 4Tabs
中文参考商品译名：
阿仑膦酸钠/维生素D3 70毫
生产厂家英文名：
MERCK
生产厂家中文参考译名：
默克制药
该药品相关信息网址1：
http://www.fosamax.com/alendronate_sodium/fosamax/hcp/about_plus_d/index.jsp
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原产地英文药品名：
ALENDRONATE SODIUM/CHOLECALCIFEROL
中文参考药品译名：
阿仑膦酸钠/维生素D3
原产地英文商品名：
FOSAMAX PLUS D(ALENDRONATE SODIUM/CHOLECALCIFEROL))70 MG/2800IU X 4Tabs
中文参考商品译名：
阿仑膦酸钠/维生素D3 70毫
生产厂家英文名：
MERCK
生产厂家中文参考译名：
默克制药
该药品相关信息网址1：
http://www.fosamax.com/alendronate_sodium/fosamax/hcp/about_plus_d/index.jsp
曾用名：
未知