Medication name
Generic name: Ifosfamide - Injection
Brand name(s): Ifex
Warning
Ifosfamide may cause serious side effects (e.g., urinary problems such as hemorrhagic cystitis, mental/mood changes, and blood/bone marrow disorders), which may require your treatment with this medication to be stopped. Tell your doctor immediately if you develop symptoms such as pink/bloody urine, frequent/painful urination, severe drowsiness, confusion, or hallucinations. Blood/bone marrow disorders can affect your body's ability to stop bleeding or fight infection. Tell your doctor immediately if you develop easy bruising/bleeding or signs of infection (e.g., fever, chills, persistent sore throat).
Uses
Ifosfamide is used to treat various cancers (such as testicular cancer). It works by slowing or stopping the growth of cancer cells.
Other uses
This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.This drug may also be used to treat other types of cancer (such as sarcomas, lung cancer).
How to use
This medication is given by injection into a vein as directed by your doctor. Dosage is based on your medical condition, body size, and response to treatment.If you are giving this medication to yourself at home, learn all usage instructions from your health care professional. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.If this medication touches your skin, immediately wash the area well with soap and water. If this medication gets in your eye, open the eyelid and flush with water for 15 minutes, then seek immediate medical attention.To help prevent urinary problems, drink plenty of fluids and urinate frequently while using this medication unless otherwise directed by your doctor. Your doctor may also prescribe other medication (e.g., mesna, IV fluids) to decrease the risk.
Precautions
Before using ifosfamide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood/bleeding disorders (e.g., anemia, low blood cell counts), current infection, kidney disease, liver disease, radiation treatment.Do not have immunizations/vaccinations without the consent of your doctor, and avoid contact with people who have recently received oral polio vaccine or flu vaccine inhaled through the nose. Wash your hands well to prevent the spread of infections.To lower your risk of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports.Before having surgery, tell your doctor or dentist that you are using this medication.This drug may make you drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.This medication may affect the production of sperm, increasing the risk of fathering a child with birth defects. Therefore, men receiving treatment with this drug should use reliable forms of birth control (e.g., condoms). Consult your doctor for details and to discuss effective forms of birth control.This medication is not recommended for use during pregnancy. It may harm an unborn baby. If you become pregnant or think you may be pregnant, tell your doctor immediately. To avoid pregnancy, both males and females using this drug should use reliable form(s) of birth control (e.g., birth control pills, condoms) during treatment. Consult your doctor for details and to discuss effective forms of birth control.This medication passes into breast milk and may have undesirable effects on a nursing infant. Therefore, breast-feeding is not recommended while using this drug. Consult your doctor before breast-feeding.
Drug interactions
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: other anti-cancer drugs, aprepitant/fosaprepitant, nalidixic acid.
Side effects
See also Warning section.Nausea, vomiting, diarrhea, stomach/abdominal pain, loss of appetite, or redness/pain/swelling at the injection site may occur. Nausea and vomiting can be severe. In some cases, your doctor may prescribe medication to prevent or relieve nausea and vomiting. Eating several small meals, not eating before treatment, or limiting activity may help lessen some of these effects. If these effects persist or worsen, tell your doctor or pharmacist promptly.Severe nausea, vomiting, and diarrhea may infrequently result in a loss of too much body water (dehydration). Contact your doctor promptly if you notice any symptoms of dehydration such as unusual decreased urination, unusual dry mouth/increased thirst, lack of tears, dizziness/lightheadedness, or pale/wrinkled skin.Temporary hair loss frequently occurs in patients using this drug. Normal hair growth should return after treatment has ended.Many people using this medication have serious side effects. However, your doctor has prescribed this drug because he or she has judged that the benefit to you is greater than the risk of side effects. Careful monitoring by your doctor may decrease your risk.Tell your doctor right away if you have any serious side effects, including: unusual weakness, seizure.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Missed dose
For the best possible benefit, it is important to receive each scheduled dose of this medication as directed. If you miss a dose, contact your doctor to establish a new dosing schedule. Do not double the dose to catch up.
Overdose
If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US National Poison Hotline at 1-800-222-1222. Canada residents can call a provincial poison control center.
Notes
Laboratory and/or medical tests (e.g., complete blood counts, blood salt/mineral levels, kidney function tests) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.
Medical alert
Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-800-854-1166 (USA) or 1-800-668-1507 (Canada).
Storage
Consult the product instructions and your pharmacist for storage details. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Photos by medication strength
Click the "Photos" link to see sample photographs for a specific medication strength.
Common strengths
ifosfamide 1 gram IV Solution

ifosfamide 1 gram/20 mL IV Soln
ifosfamide 3 gram IV Solution
ifosfamide 3 gram/60 mL IV Soln

The photos shown are samples only. Not all photos of the drug may be displayed. Your medication may look different. If you have questions, ask your pharmacist.
Important note
HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

Information last revised May 2012. Copyright(c) 2012 First Databank, Inc.

Intravenous
Solution

ifosfamide|
Osteogenic Sarcoma|Myelosarcoma|Ewing's Tumor|Burkitt's Tumor|Small Cell Lung Cancer|Oat Cell Carcinoma of the Lung|Head and Neck Cancer|Malignancy of Head and Neck|Malignant Neoplasm of Head and Neck|
Osteosarcoma of Bone|Ewing's Sarcoma|Tumor of Soft/Connective Tissue that is Usually Malignant|Invasive Bladder Cancer|Burkitt's Lymphoma|Progressive Diffuse Large B-Cell Lymphoma|Small Cell Cancer of the Lung|Non-Small Cell Lung Cancer|Testicular Germ Cell Cancer|Cancer Involving the Head or Neck|
BL|NSCLC|
Selected from NATIONAL DRUG DATA FILE (NDDF) data included with permission and copyrighted by First DataBank, Inc., 2012. This copyrighted material has been downloaded from a licensed data provider.

The above information is intended to supplement, not substitute for, the expertise and judgment of your health care professional. You should consult your health care professional before taking any drug, changing your diet, or commencing or discontinuing any course of treatment.

通 用 名：注射用异环磷酰胺     
别    名：宜佛斯酰胺,和乐生,异磷酰胺,匹服平,Z-4942,HOLOXAN,IFEX,A-4942,IFO
英 文 名：Ifosfamide for Injection
本品主要成份为异环磷酰胺，其化学名称为：3-(2-氯乙基)-2-［（2-氯乙基）氨基］四氢-2H-1，3，2- 恶 了磷-2-氧化物。
适 应 症：适用于睾丸癌、卵巢癌、乳腺癌、肉瘤、恶性淋巴瘤和肺癌等。
用法用量：
1. 单药治疗  静脉注射按体表面积每次1.2~2.5g/m2，连续5日为一疗程。
2. 联合用药  静脉注射按体表面积每次1.2~2.0g/m2，连续5日为一疗程。
3. 每一疗程间隙3~4周。500～600mg/m2。

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产地国家：美国
所属类别：抗癌药物 ->治疗睾丸癌药物
原产地英文药品名：
IFOSFAMIDE
中文参考药品译名：
未知
原产地英文商品名：
IFEX-3g/Vial
中文参考商品译名：
异环磷酰胺-3克/瓶

生产厂家英文名：
Bristol-Myers Squibb

生产厂家中文参考译名：
未知 该药品相关信息网址1：
http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=95曾用名：
未知
化合物中文译名：
异环磷酰胺

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产地国家：美国
所属类别：抗癌药物 ->治疗睾丸癌药物
原产地英文药品名：
IFOSFAMIDE
中文参考药品译名：
未知
原产地英文商品名：
IFEX-1g/Vial
中文参考商品译名：
异环磷酰胺-1克/瓶
生产厂家英文名：
Bristol-Myers Squibb
生产厂家中文参考译名：
未知
该药品相关信息网址1：
http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=95
曾用名：
未知
化合物中文译名：
异环磷酰胺