通用名称和剂型：
埃索美拉唑（三水镁）20毫克，40毫克，含EC缓释微丸。
公司：
阿斯利康制药公司
主治NEXIUM：
三联疗法（W.阿莫西林+克拉霉素）H.
根除幽门螺杆菌十二指肠溃疡病。愈合糜烂性食管炎（EE），GERD症状的短期治疗和维护。短期治疗EE由于酸介导的GERD在婴幼儿1个月<1年。为了减少NSAID相关胃溃疡的风险。长期治疗的病理性分泌过多的条件（例如，卓-艾综合征）。
NEXIUM成人剂量为：
食品前1小时服药。
整个吞下去或可能打开瓶盖和洒1汤匙苹果酱颗粒，并立即采取。打开瓶盖和混合颗粒在50ml的水，并给通过鼻饲管，冲洗管与更多的水。停赛：15ML的水包混合内容，保留2-3分钟，然后在30分钟内喝。可能会通过NG或经胃管（见文献）。
三联疗法：埃索美拉唑40毫克，每日一次+阿莫西林1G每日两次+克拉霉素500毫克，每日两次;所有10天。EE：20或40毫克，每日一次4-8周，可能会持续4-8周以上。
维护愈合EE：20毫克每日一次。症状的GERD：20毫克，每日一次，连续4周，持续4周以上。
NSAID相关胃溃疡风险降低：20毫克或40毫克，每日一次，长达6个月。
过多现象：最初40毫克，每日两次，如果需要调整，每日剂量为240毫克已使用。
严重肝功能障碍：最大20mg/day。
儿童剂量NEXIUM
EE由于酸介导的GERD：<1月：不成立的。1月，<1年：3公斤，5公斤2.5mg的。5KG-7.5千克信息：5mg。>7.5千克-12KG：10MG;：给每日一次长达6周。治疗EE：<1年：不成立的。1-11岁：20公斤10毫克;≥20千克：10或20mg; 12-17yrs：20或40毫克;：给每日一次长达8个星期。症状的GERD :1-11岁：10毫克，每日一次长达8周; 12 17yrs：20毫克，每日一次，连续4周。
请参见：
口服混悬液NEXIUM
NEXIUM IV
药理类别：
质子泵抑制剂。
警告/注意事项：
长期每日多次剂量治疗骨质疏松症相关的骨折风险增加。监控镁水平与长期治疗。怀孕（Cat.B）。哺乳母亲：不推荐。
相互作用：
伴随阿扎那韦，奈非那韦：不推荐。可能会增强沙奎那韦，监测和考虑降低沙奎那韦剂量。可能会改变胃pH依赖性的药物（例如，酮康唑，铁盐，地高辛）的吸收。拮抗氯吡格雷;考虑替代的抗血小板治疗。可能会影响通过CYP2C19代谢的药物。避免伴随着圣约翰草，利福平。可能会增强他克莫司（考虑减少剂量），西洛他唑，氨甲喋呤（考虑暂时撤离PPI）。监测华法林。抗酸剂可能会随之而来。可能导致假（+）诊断为神经内分泌肿瘤的调查结果。
不良反应：
头痛，腹泻，腹痛，恶心，胀气，便秘，口干，注射部位反应，少见的有：皮疹，过敏反应，低镁血症，可能C.
艰难梭菌相关性腹泻。儿童：此外，嗜睡，反胃，呼吸急促，ALT升高。
注意事项：
更多信息，请参阅Biaxin。Amoxil阿莫西林更多信息。
代谢：
肝（CYP2C19，CYP3A4）。97％蛋白结合。
消除：
肾（主要），粪便。
通用状况：
NO
如何提供：
30，90，1000;停赛-30包/箱; IV SOLN（单次使用小瓶）-10

EXIUM Rx
Generic Name and Formulations:
Esomeprazole (as magnesium trihydrate) 20mg, 40mg; caps containing e-c delayed-release pellets.
Company:
AstraZeneca Pharmaceuticals
Indications for NEXIUM:
Triple therapy (w. amoxicillin + clarithromycin) for H. pylori eradication in duodenal ulcer disease. Short-term treatment and maintenance of healing of erosive esophagitis (EE), symptomatic GERD. Short-term treatment of EE due to acid-mediated GERD in infants 1month to <1year. To reduce risk of NSAID-associated gastric ulcer. Long-term treatment of pathological hypersecretory conditions (eg, Zollinger-Ellison syndrome).
Adult Dose for NEXIUM:
Take 1 hour before food. Caps: swallow whole or may open caps and sprinkle pellets on 1 tablespoon applesauce and take immediately. May open caps and mix granules in 50mL of water and give via NG tube; flush tube with more water. Susp: mix contents of packet in 15mL of water, leave 2–3 minutes, then drink within 30 minutes. May give via NG or gastric tube (see literature). Triple therapy: esomeprazole 40mg once daily + amoxicillin 1g twice daily + clarithromycin 500mg twice daily; all for 10 days. EE: 20 or 40mg once daily for 4–8 weeks, may continue 4–8 more weeks.
Maintenance of healing of EE: 20mg once daily. Symptomatic GERD: 20mg once daily for 4 weeks, may continue 4 more weeks. NSAID-associated ulcer risk reduction: 20mg or 40mg once daily for up to 6 months.
Hypersecretory conditions: initially 40mg twice daily, adjust if needed; doses up to 240mg daily have been used. Severe hepatic impairment: max 20mg/day.
Children's Dose for NEXIUM:
EE due to acid-mediated GERD: <1month: not established. 1month–<1yr: 3kg–5kg: 2.5mg. >5kg–7.5kg: 5mg. >7.5kg–12kg: 10mg; for all: give once daily for up to 6 weeks. Healing of EE: <1yr: not established. 1–11yrs: <20kg: 10mg; ≥20kg: 10 or 20mg; 12–17yrs: 20 or 40mg; for all: give once daily for up to 8 weeks. Symptomatic GERD: 1–11yrs: 10mg once daily for up to 8 weeks; 12–17yrs: 20mg once daily for 4 weeks.
See Also:
NEXIUM for ORAL SUSPENSION
NEXIUM IV
Pharmacological Class:
Proton pump inhibitor.
Warnings/Precautions:
Long term and multiple daily dose therapy: increased risk of osteoporosis-related fractures. Monitor magnesium levels with long-term therapy. Pregnancy (Cat.B). Nursing mothers: not recommended.
Interactions:
Concomitant atazanavir, nelfinavir: not recommended. May potentiate saquinavir; monitor and consider reducing saquinavir dose. May alter absorption of gastric pH-dependent drugs (eg, ketoconazole, iron salts, digoxin). Antagonizes clopidogrel; consider alternative anti-platelet therapy. May affect drugs metabolized by CYP2C19. Avoid concomitant with St. John's Wort, rifampin. May potentiate tacrolimus, cilostazol (consider reduced dose), methotrexate (consider temporary withdrawal of PPI).
Monitor warfarin. May give antacids concomitantly. May cause false (+) results in diagnostic investigations for neuroendocrine tumors.
Adverse Reactions:
Headache, diarrhea, abdominal pain, nausea, flatulence, constipation, dry mouth, inj site reactions; rare: rash, allergic reactions, hypomagnesemia, possible C. difficile associated diarrhea. Children: Also, somnolence, regurgitation, tachypnea, increased ALT.
Note:
See Biaxin for more information on clarithromycin. See Amoxil for more information on amoxicillin.
Metabolism:
Hepatic (CYP2C19, CYP3A4). 97% protein bound.
Elimination:
Renal (primarily), fecal.
Generic Availability:
NO
How Supplied:
Caps—30, 90, 1000; Susp—30 packets/box; IV soln (single-use vial)—10