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索坦胶囊|SUTENT Capsules(SUNITINIB MALATE)

2013-07-24 09:30:49  作者:新特药房  来源:互联网  浏览次数:278  文字大小:【】【】【
简介: 部分中文索坦信息资料(仅供参考)【商品名】索坦【通用名】苹果酸舒尼替尼【英文名】sunitinib malate(Sutent)【用 法】每天4粒,一次顿服4粒,服用4周后需停药观察2周后继续服用【疗 程】6周/疗程 ...

部分中文索坦信息资料(仅供参考)
【商品名】索坦
【通用名】苹果酸舒尼替尼
【英文名】sunitinib malate(Sutent)
【用  法】每天4粒,一次顿服4粒,服用4周后需停药观察2周后继续服用
【疗  程】6周/疗程
【适应症】胃肠道间质瘤、肾癌
【份子结构名】苹果酸舒尼替尼
【生产厂家】Pfizer 辉瑞公司
【适应症】除了胃肠道间质肿瘤,抑制晚期肾细胞癌,现在临床证明还可以治疗非小细胞肺癌,治疗肝细胞癌.


Sutent Sunitinib Malate
Brand Name:
  Sutent 12.5mg、25mg、50mg
Strength:  12.5mg、25mg、50mg
Contents: Sunitinib Malate 12.5mg、25mg、50mg
Form: Capsules
Manufacturer: Pfizer Italia S.R.L
Country Of Origin:     Italy
SUTENT  Sunitinib by Pfizer
Sutent (also known by the generic name Sunitinib) is a medication that is used to slow the growth and spread of cancer cells in the body. It is principally used to treat kidney and intestinal cancers. Sutent is a receptor protein-tyrosine kinase inhibitor and also an angiogenesis inhibitor, which inhibits the actions of vascular endothelial growth factor (also abbreviated VEGF).
Cancer cells have abnormal rates of growth and multiply at rates that are different than normal cells. Sutent interferes with the ability of cancer cells to multiply and grow, thereby reducing the total number of cells and helping to stop their spread throughout the body.
What are the side effects of using Sutent (Sunitinib)?
Side effects associated with the use of Sutent may include mild nausea, vomiting, diarrhea, constipation or loss of appetite, headache, joint or muscle pain, changes in hair color or texture, and strange tastes in the mouth.
More severe side effects are possible and may include shortness of breath, significant weakness and feeling faint, swelling in limbs or face, chest pain or pressure, fatigue, numbness or tingly feeling anywhere in the body, confusion, bruising, white patches or sores in and on the mouth, vomiting or coughing of blood or material that looks like wet coffee grounds, and redness or peeling rash on the hands or soles of your feet. Contact your doctor immediately if you experience these or any other unusual symptoms while using this medicine.
Allergic reactions are possible when receiving this drug and include a sudden rash, itchiness or swelling of the skin, mouth, or throat, and difficulty breathing. If you suspect an allergic reaction while taking Sutent, seek emergency medical care.
What precautions are advised when using Sutent (Sunitinib)?
Receiving Sutent may weaken your body’s immune system, so avoid people who have colds, the flu, or other infections.
There are various drugs that can interfere with the way Taxotere works in your body including certain anti-fungals and antibiotics, corticosteroids, other cancer medicines, immunosuppressants, seizure medicines, and any herbal or other nutritional supplements you may be taking. Discuss these with your doctor.
Women who are pregnant or nursing should not take Sunitinib unless specifically prescribed by their doctor. Women taking this medicine are advised against becoming pregnant because this drug could harm an unborn baby.
What happens with an overdose of Sutent (Sunitinib)?
Overdoses with Sutent may include chills, tremors, stomach pain, weakness, or any of the severe side effects listed previously. Contact a doctor right away if you suspect you have received an overdose of this drug.  
Sutent Intake Guidelines
Patients are recommended to ask their personal healthcare provider to explain them exactly how they should take Sutent. It is recommended to listen and remember all of the doctor’s instructions. If the patients do not understand one or more of the doctor’s recommendations they should ask him again or contact a pharmacist for more information.
Every dose of Sutent must be taken with at least two quarts of fluid in order to avoid an upset stomach. Persons who are under treatment with this medicine should avoid drinking, should have an equilibrate diet and often wash their hands. Patients who are taking this medicine have a high risk of infection this is why it is recommended to avoid crowded places, people with colds. In order to reduce the symptoms, patients are recommended to take anti-nausea drugs and to eat small and frequent meals.
舒尼替尼(sunitinib malate)是由美国辉瑞公司开发的一种口服小分子多靶点酪氨酸激酶受体抑制剂。分别于2006年1月和2007年1月由美国FDA和欧洲EMEA批准上市,商品名为Sutent,为口服胶囊制剂,用于治疗胃肠道间质肿瘤(GIST)和晚期肾细胞瘤。
舒尼替尼是一种能够抑制多种酪氨酸激酶受体的小分子化合物,它可以通过抑制血管内皮生长因子受体、血小板衍生生长因子受体、干细胞因子受体、Fms-样酪氨酸激酶一3、集落刺激因子受体I型和神经胶质细胞系衍生神经营养因子受体的酪氨酸激酶受体的活性,阻断肿瘤细胞生长的血液和营养供应,从而产生抗血管生成和抗肿瘤作用,此外,Sutent还可以直接杀伤肿瘤细胞。
Ⅲ期临床试验结果证实,与使用干扰素相比,晚期/转移性肾细胞癌(MRCC)患者使用Sutent,病情不恶化患者的存活时间由5个月增加到11个月。口服Sutent可能会出现乏力、虚弱、恶心、消化不良、腹泻或口腔黏膜炎、中性粒细胞减少、血小板减少以及皮炎、皮肤脱色或毛发褪色等轻中度不良反应,患者能够很好地耐受。
目前该药已经得到我国药监部门批准上市,并于国内开展舒尼替尼(Sutent)治疗转移性肾癌的多中心开放性Ⅳ期临床试验。
--------------------------------------------------
产地国家: 意大利
原产地英文商品名:
SUTENT 50mg/cap 14caps/bottle
原产地英文药品名:
SUNITINIB MALATE
中文参考商品译名:
索坦 50毫克/胶囊 14胶囊/瓶
中文参考药品译名:
苹果酸舒尼替尼
生产厂家中文参考译名:
pfizer
生产厂家英文名:
pfizer
--------------------------------------------------
产地国家: 意大利
原产地英文商品名:
SUTENT 25mg/cap 28caps/bottle
原产地英文药品名:
SUNITINIB MALATE
中文参考商品译名:
索坦 25毫克/胶囊 28胶囊/瓶
中文参考药品译名:
苹果酸舒尼替尼
生产厂家中文参考译名:
pfizer
生产厂家英文名:
pfizer
--------------------------------------------------
产地国家: 意大利
原产地英文商品名:
SUTENT 12.5mg/cap 28caps/bottle
原产地英文药品名:
SUNITINIB MALATE
中文参考商品译名:
索坦 12.5毫克/胶囊 28胶囊/瓶
中文参考药品译名:
苹果酸舒尼替尼
生产厂家中文参考译名:
pfizer
生产厂家英文名:
pfizer
--------------------------------------------------
产地国家: 加拿大
原产地英文商品名:
SUTENT 25mg/Capsule 28Capsules/bottle
原产地英文药品名:
SUNITINIB MALATE
中文参考商品译名:
索坦 25毫克/胶囊 28胶囊/瓶
中文参考药品译名:
苹果酸舒尼替尼
生产厂家中文参考译名:
pfizer Canada
生产厂家英文名:
pfizer Canada
该药品相关信息网址1:
http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=369
该药品相关信息网址2:
http://www.sutent.com/

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