英文药名：Mucosolvan（Ambroxol Hydrochloride）

中文药名：盐酸氨溴索片和溶液

生产厂家：Teijin
适应症
适用于伴痰液分泌不正常及排痰功能不良的急性、慢性呼吸道疾病。
例如慢性支气管炎急性加重、喘息型支气管炎、支气管扩张及气管哮喘的祛痰治疗。术后肺部并发症的预防性治疗。
用法用量
成人：
每日3次，每次1片。若每日2次，每次2片服用，可提高疗效。沐舒坦片剂应在餐后以液体送服。
不良反应
通常能很好耐受，曾有轻度的胃肠道副作用报道，主要为胃部灼热、消化不良和偶尔出现恶心、呕吐，过敏反应极少出现。
禁忌
已知对盐酸氨溴索或其他配方成分过敏者不宜使用。
注意事项
1.孕妇及哺乳期妇女慎用。
2.儿童用量请咨询医师或药师。
3.应避免与中枢性镇咳药（如右美沙芬等）同时使用，以免稀化的痰液堵塞气道。
4.沐舒坦为一种粘液调节剂，仅对咳痰症状有一定作用，在使用时应注意咳嗽、咳痰的原因，如使用7日后未见好转，应及时就医。
5.如服用过量或出现严重不良反应，应立即就医。
6.对沐舒坦过敏者禁用，过敏体质者慎用。
7.沐舒坦性状发生改变时禁止使用。
8.请将沐舒坦放在儿童不能接触的地方。
9.儿童必须在成人监护下使用。
10.如正在使用其他药品，使用沐舒坦前请咨询医师。
孕妇及哺乳期妇女用药
孕妇及哺乳期妇女慎用。
老年用药
没有特殊注意事项，请按成人用法用量。
药物相互作用
1.沐舒坦与抗生素（阿莫西林、头孢呋新、红霉素、强力霉素）同时服用，可导致抗生素在肺组织浓度升高。
2.如与其他药物同时使用可能会发生药物相互作用，详情请咨询医师或药师。
药理毒理
药理学：
沐舒坦具有粘液排除促进作用及溶解分泌物的特性。它可促进呼吸道内粘稠分泌物的排除及减少粘液的滞留，因而显著促进排痰，改善呼吸状况。
应用沐舒坦治疗时，病人粘液的分泌可恢复至正常状况。咳嗽及痰量通常显著减少，呼吸道上粘膜的表面活性物质因而能发挥其正常的保护功能。
毒理学：
急性毒性试验中氨溴索的毒性指数非常低。氨溴索无致突变性（Ames和微核试验）。对于小鼠及大鼠的致癌性研究显示，氨溴索无致癌性。
药代动力学
半衰期7—12小时，未发现蓄积，主要由肝脏代谢，90%由肾脏清除。
包装
PTP：
100錠(10錠×10)、500錠(10錠×50)、1,000錠(10錠×100)、2,100錠(21錠×100)、3,000錠(10錠×300)
瓶：1,000錠(褐色ガラス瓶入り)

40mL（褐色ガラス瓶入り）
250mL（褐色ガラス瓶入り）
注：使用请参照原处方：http://www.info.pmda.go.jp/go/pack/2239001F1696_1_01/
Mucosolvan (Behringer Ingelheim)
DESCRIPTION
The active agent, Ambroxol is a proven, reliable and effective expectorant.
It enables sticky phlegm to be removed from the respiratory system faster and more easily by enhancing the bronchial secretions that loosen congested phlegm. Ambroxol also releases and
strengthens the cilia (tiny striking hairs inside the windpipe and bronchial tubes), which can then expel the abnormal phlegm with their conveyor-belt like action.
Ambroxol increases the body's production of surfactant, a substance that promotes the clearance mechanism for elimination of germs or other pathogens, which helps to prevent and overcome infection in the bronchi.
Ambroxol was first introduced in the form of Mucosolvan in 1978 and has proven to be a reliable, trusted expectorant for the treatment of productive cough. Mucosolvan� is one of the leading therapies for cough and is available in many countries around the world.
MODE OF ACTION
Ambroxol is the active agent in Mucosolvan.
It makes phlegm in the airways thinner and less sticky.
It does this by increasing the body's natural production of surfactant. This contributes to a secretomotoric effect:
it helps the cilia - tiny hairs that line the respiratory tract - to transport the phlegm out of the lungs.
Here is a step-by-step description of how Ambroxol works:
1. Ambroxol is quickly metabolised by the body.
It goes straight to work at the mucus-secreting cells, where it changes the mucus so it becomes less viscous.
This thinner, more liquid mucus helps lift the heavy, sticky phlegm off the walls of the airways.
2. Ambroxol frees and activates the cilia. Thanks to the effect of the thinner mucus, the cilia are no longer clogged by the thick, sticky phlegm. They are free to move again and help to push the phlegm up and out of the respiratory tract. Furthermore, Ambroxol enhances the movement of the cilia so they transport phlegm out of the airways more quickly.
3. Ambroxol is not a cough suppressant. It does not interfere with the body's natural cough response.
This is important, because coughing is still needed to eject the excess phlegm from the airways. Ambroxol makes it easier to get the phlegm moving again.
HOW SUPPLIED
Mucosolvan Productive Cough Syrup
Mucosolvan Productive Cough Syrup for Children
Mucosolvan Productive Cough Cough Pastilles
Mucosolvan Productive Cough One-A-Day Capsules
Mucosolvan Productive Cough Effervescent Tablets
Mucosolvan Productive Cough Tablets
Marketed by:
Behringer Ingelheim Mucosolvan is a registered trademark of Behringer Ingelheim
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注：以下产品不同规格和不同价格，购买以咨询为准！
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产地国家:日本
原产地英文商品名:
MUCOSOLVAN TAB(ムコソルバン錠) 15mg/tab 100tabs/box
原产地英文药品名:
Ambroxol Hydrochloride
中文参考商品译名:
沐舒坦片(ムコソルバン錠) 15毫克/片 100片/盒
中文参考药品译名:
盐酸氨溴索
生产厂家中文参考译名:
帝人
生产厂家英文名:
Teijin