部份中文阿罗洛尔处方资料（仅供参考）
药理作用
本品为β受体阻滞剂，兼有适度的α受体阻滞作用，能降低血压，治疗心绞痛及心律失常。该药同时具有骨骼肌β2受体阻断作用，在MPTM诱发的震颤(猴)试验中，被证实有抗震颤作用。本品具有β-受体阻滞作用及适度的α-受体阻滞作用，其作用强度之比为8∶1。β-受体阻滞作用可抑制亢进的心功能，使心肌耗氧量减少，血压降低；β-受体阻滞作用又使外周血管阻力不致上升。
药动学
口服后2h血药浓度达峰值，半衰期为10h。血中及尿中主要代谢物为氨基甲酰基水解后的活性代谢物。
适应证
用于轻至中度原发性高血压、心绞痛、心动过速性心律失常；也用于特发性震颤（原发性震颤)。
禁忌证
1.有重度心动过缓，房室传导阻滞(Ⅱ度、Ⅲ度)，窦房传导阻滞的患者。
2.有糖尿病性酮症，代谢性酸中毒的患者。
3.有可能出现支气管哮喘，支气管痉挛的患者。
4.有心源性休克的患者。
5.有肺动脉高压所致右心衰竭的患者。
6.有充血性心衰竭的患者。
7.孕妇或有怀孕可能的妇女。
注意事项
1.慎用：特发性低血糖、长时间禁食、末梢循环障碍循环；肝肾功能障碍者。
2.服药期间禁止驾车。
3.停药时缓慢减退。
4.正在服用类似化合物的心绞痛患者须缓慢减量。手术前48h内不宜给药。
不良反应
1.严重不良反应：偶见心衰，房室传导阻滞，心动过缓。
2.一般不良反应：头痛倦怠、软便腹泻、腹部不适、腹痛、恶心呕吐、偶尔哮喘、皮肤过敏、皮疹、瘙痒、有时出现GOT、GPT、BUN及血糖升高。
3.不良反应发生率为8.9%，主要有心动过缓、心悸、头晕、乏力、抑郁、腹痛、恶心、食欲缺乏、稀便、转氨酶升高、雾视、泪液分泌减少、水肿、血尿素氮升高。罕见咳嗽、皮疹、肌肉痛及空腹血糖升高。
用法用量
1.原发性震颤：成人每次5mg，每天2次，疗效不充分时可增加用量，每次10mg，每天2次，但每天不能超过30mg。
2.高血压(轻度～中度)、心绞痛、心律失常：成人每次10mg，每天2次，疗效不充分时，可增至每天30mg。
药物相应作用
1.联合应用对交感神经系统有抑制作用的药物(如利血平)有时可出现过度抑制状态，应减量慎重应用。
2.联合应用降血糖药有时可增强降血糖作用，故应慎重应用。
3.联合应用钙拮抗剂有时可相互增强作用。
4.可乐定有可能增强停药后的回跳现象。
5.联合应用砒二丙胺，普鲁卡因胺，阿马林有时可出现心脏传导系统阻滞现象。
专家点评
该药同时具有骨骼肌β2受体阻断作用，在MPTM诱发的震颤试验中，证明有抗震颤作用。本品属α、β受体阻断剂。具有明显的降压作用，并具有抑制高血压所致心、肾等血管病变的作用。因此临床常用于抗心绞痛和抗心律失常。冠心病心绞痛患者使用β受体阻断剂治疗突然停用时，可发生心绞痛恶化，甚至出现心肌梗死或室性心律失常。因此，临床应用要特别谨慎。老年人用药应从小剂量开始。

Essential hypertension(mild to moderate disease) Angina Tachyarrhythmia Essential tremor DOSAGE AND ADMINISTRATION If essential hypertension (mild to moderate disease), angina pectoris, of tachyarrhythmia Usually, the arotinolol hydrochloride in adults, it is administered orally twice a 20mg 1 day. In addition, it is assumed that it is adjusted according to your age and symptoms, etc., are not adequately responsive to case, it is possible to increase up to 30mg per day.
In the case of essential tremor Usually, the arotinolol hydrochloride in adults, starting daily dose 10mg, sufficiently effective if it is administered orally twice a maintenance dose of 20mg 1 day. It is assumed to be adjusted according to the age and symptoms such as, but not more than 30mg 1 day. PRECAUTIONS Careful administration (Thing. Administering carefully be carefully observed, such as a combination of digitalis agent) patients at risk
of congestive heart failure there is a possibility that the symptoms of congestive heart failure is worse to suppress the [cardiac function. ] It is important to note the blood sugar level so easy to mask the sympathetic nervous system reaction idiopathic hypoglycemia, diabetes mellitus inadequate control, tachycardia or the like which is a pre-symptomatic patients with long-term fasting state [of hypoglycemia. ] There is a possibility that the [symptoms worsen patients with hypotension, bradycardia, atrioventricular block of (I degree). ] There is a possibility that the affected metabolism patients with liver and kidney dysfunction [severe drug and excretion. ] (See section "administration for the elderly") Elderly There is a possibility that the symptoms worse to suppress the expansion of [patients with peripheral vascular (Raynaud's syndrome, intermittent claudication, etc.) the peripheral circulation disorder. ] Important Precautions If administered over a long period of time, and be carried out on a regular basis (pulse, blood pressure, electrocardiogram, X-rays, etc.) heart function test.
Should be discontinued or weight loss in the case that caused the low blood pressure and when became especially bradycardia.
Further, the use of atropine as needed. In addition, liver function, renal function, attention should be paid to the image, such as blood. When you stop the administration suddenly in patients with angina-like compound of (propranolol) in use, patients with symptoms worsening, caused the myocardial infarction have been reported, the weight loss gradually if it takes a drug holiday that is, trying to fine-tune the observation. Also, Be careful you do not want to discontinue medication without a physician's supervision to the
patient. Application of angina other than, for example, even when administered in arrhythmia, to the attention of the same, especially in the elderly. Should not be administered 48 hours prior to surgery is desirable. When using the essential tremor, and be subjected to discrimination between other diseases that produce tremor similar carefully monitored, by the diagnosis, it is administered only to patients who are distinguished from essential tremor. The such as discontinuation or dose reduction if symptoms were observed
carefully monitored because there is that compared to when bradycardia, dizziness, low blood pressure, etc.
were administered to hypertensive patients, it is more common when administered in essential tremor By performing the appropriate actions. Because you might wander dizziness may occur, the (initial administration in particular) patients of this drug during administration, and
allowing attention to the work of the machine with operator, such as risk of a motor vehicle. Side effect Overview of side effects situation This drug has not conducted a survey side effects incidence of drug use investigation or the like becomes clearer.
Term side effects and serious side effects Clinically significant adverse reactions (Incidence unknown) Heart failure, atrioventricular block, sinoatrial block, sick sinus syndrome, bradycardia It is performed on a regular basis the heart function tests, and appropriate measures should be taken of such as discontinuation or dose reduction in the case of such side effects were expressed.
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产地国家: 日本
原产地英文商品名:
Acemail（アセメール錠）5mg 100tabs
原产地英文药品名:
Arotinolol
中文参考商品译名:
Acemail（アセメール錠）5毫克/片 100片/盒
中文参考药品译名:
阿罗洛尔
生产厂家英文名:
Sawai
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产地国家: 日本
原产地英文商品名:
Acemail（アセメール錠）10mg 100tabs
原产地英文药品名:
Arotinolol
中文参考商品译名:
Acemail（アセメール錠）10毫克/片 100片/盒
中文参考药品译名:
阿罗洛尔
生产厂家英文名:
Sawai