部份中文厄多司坦处方资料（仅供参考）
药理作用:
本品属粘液溶解剂,为一前体药物,其分子结构中含有被封闭的巯基(-SH),通过肝脏生物转化成含有游离巯基的活性代谢产物而发挥粘痰溶解作用。其作用机理可能主要是通过含游离巯基的代谢产物使支气管分泌物的粘蛋白的二硫键断裂,改变其组成成分和流变学性质(降低痰液粘度),从而有利于痰液排除。另外,本品还具有增强粘膜纤毛运动功能等作用。
毒理研究:
重复给药毒性:Beagle犬和SD大鼠连续经口给予本品3个月的无毒性反应剂量分别为48mg/kg/日和300mg/kg/日(按体表面积折算,分别相当于人临床拟用剂量的2.7倍和4.9倍),与给药相关的毒性反应为尿酮体阳性,停药后可恢复。遗传毒性:本品Ames试验、CHL细胞染色体畸变试验和ICR小鼠骨髓微核试验结果均为阴性。致畸敏感期生殖毒性:SD孕大鼠在怀孕第6～15天连续灌服本品,剂量达1000mg/kg/日(按体表面折算,相当于人临床拟用剂量的162倍)时,母鼠体重增长抑制,胎仔头骨、舌骨、胸椎椎体中心及耻骨骨化迟缓,尾椎、剑突、掌骨骨化点数减少。无毒性反应剂量为500mg/kg/日(按体表面积折算,相当于人临床拟用剂量的81倍)。
药动学：
本品经口服后迅速被胃肠道吸收,并很快代谢转化为3个含有游离巯基的代谢物,代谢物经尿、粪便和胆汁清除。健康成人单次或多次口服本品后发现,血浆中会出现少量、短时的原形药物,代谢物有64.5%与血浆蛋白结合,其无机硫酸盐化合物主要经肾排泄,食物对其吸收代谢和排泄的影响很小。多次给药未发现药物蓄积作用。患急性或慢性支气管炎的,儿童或成年人及健康老年志愿者口服相当于成人剂量的厄多司坦后,药物代谢同健康成年人一样。中度肝肾功能障碍不会显著改变厄多司坦的药物动力学特性。
适应症：
粘痰溶解药。用于急性和慢性支气管炎痰液粘稠所致的呼吸道阻塞。 用法用量：口服,一次300mg,一日2次。
不良反应：
较常见的不良反应为消化不良、恶心、呕吐、胃痛等胃肠道反应。相互作用： 注意事项：
1、服药期间,应避免同服强力镇咳药,亦不能同服使支气管分泌物减少的药物。
2、有胃溃疡或十二指肠溃疡的患者,慎用本品。
3、对本品过敏者禁用。不足15岁的儿童、严重肝肾功能不全者禁用。

Erdotin (Erdosteine)
Generic for Erdotin (Erdosteine) Is an oral mucolytic agent indicated for the treatment of acute exacerbations of chronic bronchitis (chronic obstructive pulmonary disease (COPD)).
Recommended Dosage - Discount Prescription Drug Generic for Erdotin
The dosage of Generic for Erdotin prescribed to each patient will vary. Always follow your physician’s instructions and/or the directions on the prescription drug label.
Missed Dose of Generic for Erdotin
If your physician has instructed or directed you to take Generic for Erdotin medication in a regular schedule and you have missed a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, then skip the missed dose and go back to your regular dosing schedule. Do not double the doses unless otherwise directed.
Overdose of Generic for Erdotin
Any medication taken in excess can have serious consequences. If you suspect an overdose of Generic for Erdotin, seek medical attention immediately.
Side Effects of Generic for Erdotin
Like other medicines, Generic for Erdotin can cause some side effects. If they do occur, the side effects of Generic for Erdotin are most likely to be minor and temporary. However, some may be serious and may require the individual to inform the doctor or visit the nearest hospital immediately.
It is pertinent to note that side effects of Generic for Erdotin cannot be anticipated. If any side effects of Generic for Erdotin develop or change in intensity, the doctor should be informed as soon as possible.
Generic for Erdotin can cause side effects such as nausea, vomiting, headache, and gastrointestinal problems. This is not a complete list of all side effects. Do concur with your doctor and follow his directions completely when you are taking Generic for Erdotin.
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产地国家: 意大利
原产地英文商品名:
Erdotin 300mg  20capsules
原产地英文药品名:
Erdosteine
中文参考商品译名:
好舒丹 300毫克/胶囊 20胶囊/盒
中文参考药品译名:
厄多司坦
生产厂家英文名:
Rottapharm SpA