英文药名：ZIONE INJECTION/LIDOCAINE(Aluminum　Potassium　Sulfate Hydrate)

中文药名：硫酸铝钾水合物注射液/利多卡因

生产厂家：田边三菱制药

ジオン注　無痛化剤付

治疗类别名称
内痔硬化剂
商標名
ZIONE INJECTION/LIDOCAINE
一般名
硫酸铝钾水合物
化学名
Aluminum　Potassium　Sulfate Hydrate
分子式
AlK（SO4）212H2O
分子量
474.39
性状
在粉末或无色结晶，以白色，无臭，味微甜，有较强的收敛。
它易溶于水，并在乙醚或乙醇（95）中几乎不溶。
是酸性的（1→20）的水溶液。
一般名
单宁酸
化学名
Tannic　Acid
性状
无定形棕色的粉末，在海绵状或小片的质量闪亮的淡白色至黄色，有异味或略，或不闻，味极苦。
它非常易溶于乙醇（95），并在乙醚或几乎不溶于水。
疗效或有效性
混合痔以及其他的痔疮
用法与用量
服用这种药物之前，放松肛门括约肌的骶部硬膜外麻醉或腰麻。
在使用时，除了连接到（10mL）溶液，1小瓶用生理盐水注二酮，2％的溶液，其制备如硫酸铝钾水合物，10毫升和20毫升的盐水。
通常成人给药粘膜下分裂的9 13毫升2％的溶液，作为每一个主要的痔疮。
并且应当注意的是，该剂量可以根据病人的情况进行调整，每单次治疗的总剂量为60毫升溶液应该在2％以内。
当管理的四个主要痔疮。应参照以下的标准剂量，给予谨慎的管理程序。
<标准dose>
加入3ml：极痔上黏膜下层
2-4毫升：痔的中央部分的黏膜下层
1-2毫升：固有层痔的中央部
3-4毫升：痔黏膜下层的下极
<Delivery技术(four-step注射method)>
1）当局极痔上黏膜下层
穿刺注射针管2mL管理城市深入到粘膜下层（可能有时打不触及）上极直肠痔上动脉搏动。然后，同时将针尖1毫升手。
给药后，在粘膜表面有点发白。

2）中央部分痔粘膜下层
管理作为一个标准的量加入到1毫升体积痔城市穿刺针深入到黏膜下层中的中心的主痔。
固有层痔3的中央部
“在粘膜管理的中央部分痔”1 2毫升，管理到固有层拉针，一只小手。
黏膜表面微微凸起的剂量是足够的。
下极黏膜下层的痔
给药2-3毫升城市穿刺针深入到粘膜下层的网站（有0.1 0.2厘米齿状线以上）下极痔。然后，我管理，同时将针尖1毫升手。
以下情况：
1立方厘米，体积的主五痔。有痔疮和副给药时，不会有任何行政上极部分和下极痔疮痔疮。
不管理在肌肉层.如果你不小心在肌肉层的穿刺，回报可以给药一次的针尖，再次从穿孔。
注意的症状，膀胱刺激症状，前列腺癌和阴道壁小心，不要管理。
请注意，行政或向下的化学溶液渗透到齿状线下方，它可能会引起疼痛嵌顿痔或肛门部位会出现齿状线。
后所有痔疮。管理，防止过度的炎症反应得到足够的效果，可以在整个区域充分按摩手指散发的化学管理。
包装规格
10毫升/1瓶(添+10mL稀释后的溶液)

生产厂家：
田边三菱制药

完整资料附件：http://www.info.pmda.go.jp/go/pack/2559500A1023_2_07/
ZIONE INJECTION/LIDOCAINE-硫酸铝水合物-是唯一治疗各类型痔疮的新型注射剂
ZION Injection with analgesic agent（ジオン注無痛化剤付） 
Brand name : ZION Injection with analgesic agent
　Active ingredient: Aluminum potassium sulfate hydrate
 Tannic acid
 Lidocaine (analgesic agent)
　Dosage form: Injection
　Print on wrapping: 
Effects of this medicine
This medicine induces acute inflammation in haemorrhoids and cause fibrosis of tissue, and then reduces the haemorrhoids which protrude outside the anus. Therefore, it improves haemorrhoid symptoms including bleeding and protrusion of the haemorrhoid outside the anus.
It is usually used to treat internal haemorrhoid with prolapse.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
You are a patient on dialysis therapy.
•If you are pregnant, may be pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•In general, this medicine is injected into several parts of the affected area.
Precautions while taking this medicine
•Observe your condition after injection, because transient fever may occur until 2 weeks after injection of this medicine. Consult with your doctor if you develop a fever.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include fever, decreased blood pressure, headache, nausea, loss of appetite and proctalgia. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•dizziness on standing up, dizziness, weakness [decreased blood pressure, bradycardia]
•abdominal pain, blood in stool, perianal pain [rectal ulcer]
•thin stool, difficult to defecate [rectal stenosis]
•pale face, cold sweat, dizziness on standing up [shock]
•palpitation, rapid temperature rise, muscle stiffness [malignant hyperthermia]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Mitsubishi Tanabe Pharma CorporationInjection
Revised: 2/2014
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.