英文药名：Tenozet Tablets(Tenofovir Disoproxil Fumarate)

中文药名：替诺福韦酯富马酸盐片

生产厂家： 葛兰素史克日本公司
药品介绍：
抗病毒化疗药物（Ｂ型肝炎治療薬）
批准上市日期：2014年5月
商標名
Tenozet Tablets
一般名
テノホビル ジソプロキシルフマル酸塩
（Tenofovir Disoproxil Fumarate）
化学名
Bis（isopropoxycarbonyloxymethyl）｛［（1R）-2-（6-amino-9H-purin-9-yl）-1-methylethoxy］methyl｝phosphonate monofumarate
分子式
C19H30N5O10P・C4H4O4
分子量
635.51
構造式

性状
它是一种白色至黄白色结晶粉末，易溶少量甲醇和乙醇，和微溶于丙酮，水和不溶于乙醚。
熔点
112〜119℃
分配系数
（1 - 辛醇/pH6.5磷酸盐缓冲溶液）1.25
药理作用
本品是一种新型核苷酸类逆转录酶抑制剂。以与核甘类逆转录酶抑制剂类似的方法抑制逆转录酶，从而具有潜在的抗HIV-1活性。替诺福韦的活性成分替诺福韦双磷酸盐可通过直接竞争性地与天然脱氧核糖底物相结合而抑制病毒聚合酶，及通过插入DNA中终止DNA链。
适应症症
用于治疗HIV、HBV感染。本品和其他逆转录酶抑制剂合用于HIV-1感染、乙肝的治疗。
用法用量
口服：每日1次，每次300mg，与食物同服。
包装规格
300毫克/片*30片/瓶
生产商： 葛兰素史克公司
完整资料附件：http://meds.qlifepro.com/detail/622336301/

Tenozet Tablets（Tenofovir disoproxil fumarate）
Tenozet Tablets 300mg（テノゼット錠300mg） 
Brand name : Tenozet Tablets 300mg
　Active ingredient: Tenofovir disoproxil fumarate
　Dosage form: white or light blue tablet, major axis: 17.0 mm, minor axis: 10.5 mm, thickness: 5.0 mm
　Print on wrapping: 
Effects of this medicine
This medicine decreases the amount of virus by suppressing the growth of the hepatitis B virus and improves liver function.
It is usually used to treatchronic hepatitis B virus infection.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•In general, for adults, take one tablet (300 mg of the active ingredient) at a time once a day. Strictly follow the instructions.
•If you miss a dose, take a dose as soon as possible. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
•If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop taking the medicine unless your doctor instructs you do so.
Precautions while taking this medicine
•It is important that you receive medical examination on a regular basis because symptoms of chronic hepatitis B and hepatic cirrhosis B are extremely difficult to detect on your own.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include nausea and abdominal pain. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•edema, decreased urine output, thirst [renal failure, severe renal dysfunction]
•hyperpnea, disturbed consciousness, shivering limbs [lactic acidosis]
•fatty deposition in hypodermal tissues or internal organs, enlargement of the liver (pressured feeling in the right hypochondrium) [severe liver enlargement due to fatty deposition (hepatic steatosis)]
•nausea, severe abdominal pain, back pain [pancreatitis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
•Discard the remainder. Do not store them. Consult with your dispensing pharmacy or medical institution on how to discard the medicine.
GlaxoSmithKline K.K.Internal
Revised: 1/2016
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.