英文药名：RABEPRAZOLE Sodium Tablets(Sodium rabeprazole)

中文药名：雷贝拉唑钠片

生产厂家：科研制药
治疗类别名称
质子泵抑制剂
商標名
Sodium Rabeprazole Tablets
構造式

一般名
ラベプラゾールナトリウム（Rabeprazole Sodium）
化学名
Monosodium（RS）-2-（｛［4-（3-methoxypropoxy）-3-methylpyridin-2-yl］methyl｝sulfinyl）-1H-benzoimidazolide
分子式
C18H20N3NaO3S
分子量
381.42
性　状
白色至淡黄色粉末。
易溶于水，溶于乙醇（99.5）。
易溶于0.01摩尔/ L氢氧化钠的TS。
它是吸湿性的。
水溶液（1→20）示出了没有旋光性。
操作注意事项
稳定性试验
使用结果的最终包装产品（40±1℃，75±5％的相对湿度，6个月）加速试验，雷贝拉唑钠片10mg“沙”据推测，在正常的市场分布三年稳定在这是。
适应证
胃溃疡，十二指肠溃疡，吻合口溃疡，反流性食道炎，佐林格 - 埃利森综合征，非糜烂性胃食管反流病
下面根除幽门螺杆菌的辅助
胃溃疡，十二指肠溃疡，胃MALT淋巴瘤，特发性血小板减少性紫癜，胃早期胃癌后内镜治疗，幽门螺杆菌感染性胃炎
用法用量
・ 胃溃疡，十二指肠溃疡，吻合口溃疡，卓 - 艾综合征
成人：每日口服一次，每次10毫克，重者口服给药20MG。此外，胃溃疡，长达8周在吻合口溃疡，长达6周的十二指肠溃疡和管理。
・ 返流性食管炎
成人：每日口服一次，每次10毫克，重者口服给药20MG。此外，长达8周的施用。另外，在与质子泵抑制剂的效果不充分的处理的情况下，两次10mg的或一次20毫克每天1次，也能够进一步8周口服给药。
然而，经两次20Mg1_nichi仅限于重度粘膜损伤病例。
在返流性食管炎的维持治疗反复复发或复发，通常，每日口服一次，每次10毫克。
・ 非糜烂性胃食管反流病
成人：每日口服一次，每次10毫克。此外，通常最多4周的给药。
・ 根除幽门螺杆菌的辅助
成人：每日口服一次，每次10毫克，1次将750mg（效价），为阿莫西林水合物，一次作为克拉霉素200毫克的三种药物同时（效价），每7天口服给药。
此外，克拉霉素如果需要可以增加。然而，一旦两次400毫克，每天（效价）和上限。
质子泵抑制剂，如果由阿莫西林水合物和克拉霉素的三药物施用根除治疗幽门螺杆菌是不成功的，因为治疗性替代此，通常，一旦为10mg作为用于成年人雷贝拉唑钠，阿莫西林一旦作为水合物将750mg（效价），并在同一时间的250mg如甲硝唑，7天口服给药，一天两次一次三种药物。
药效药量
雷贝拉唑钠是质子泵抑制剂。成为在酸分泌细胞（亚磺酰胺体）的酸性区域的活性形式，质子泵（H +，K + -ATP酶）来修改抑制酶活性的SH基团，抑制胃酸分泌。
包装规格
片剂
10毫克：100片（PTP），500片（PTP）

20毫克：100片（PTP），500片（PTP）

生产商：科研制药
RABEPRAZOLE Sodium Tablets 10mg "KAKEN"（ラベプラゾールナトリウム錠10mg「科研」） 
Brand name : RABEPRAZOLE Sodium Tablets 10mg "KAKEN"
　Active ingredient: Sodium rabeprazole
　Dosage form: pale yellow tablet, diameter: 6.7mm, thickness: 3.3mm
　Print on wrapping: ラベプラゾールナトリウム錠10mg「科研」, RABEPRAZOLE SODIUM Tab.10mg 「KAKEN」, 10mg, KC80
RABEPRAZOLE Sodium Tablets 20mg "KAKEN"（ラベプラゾールナトリウム錠20mg「科研」） 
Brand name : RABEPRAZOLE Sodium Tablets 20mg "KAKEN"
　Active ingredient: Sodium rabeprazole
　Dosage form: pale yellow tablet, diameter: 7.2mm, thickness: 3.4mm
　Print on wrapping: ラベプラゾールナトリウム錠20mg「科研」, RABEPRAZOLE SODIUM Tab.20mg 「KAKEN」, 20mg, KC81
Effects of this medicine
This medicine inhibits the mechanism of gastric acid secretion in gastric mucosal cells to suppress gastric acid secretion. It consequently results in rapid healing of gastric and duodenal ulcer, and relieves pain and heartburn attributed to reflux esophagitis.
It is usually used in the treatment of gastric ulcer, duodenal ulcer, reflux esophagitis, and non-erosive gastroesophageal reflux disease. It is also used for adjunctive medicine to eradicate Helicobacter pylori bacteria in the stomach in gastric ulcer, duodenal ulcer, gastric MALT lymphoma, idiopathic thrombocytopenic purpura, and after endoscopic therapy for early gastric cancer, and Helicobacter pylori gastritis with other antibacterial medicines.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have liver problems.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•For gastric ulcer and duodenal ulcer, anastomotic ulcer and Zollinger-Ellison syndrome: In general, for adults, take 1 tablet (10 mg of the active ingredient) at a time, once daily. However, the dosage may be increased up to 2 tablets (20 mg), once daily. Duration of taking the medicine is up to 8 weeks for gastric ulcer and anastomotic ulcer; 6 weeks for duodenal ulcer.
For reflux esophagitis: In general, for adults, take 1 tablet (10 mg of the active ingredient) at a time, once daily. However, the dosage may be increased up to 2 tablets (20 mg), once daily. Duration of taking the medicine is up to 8 weeks. When proton pump inhibitor treatment is ineffective, take 1 tablet (10 mg) or 2 tablets (20 mg) at a time, twice daily for further 8 weeks. However, a dose of 2 tablets (20 mg) at a time, twice daily is only used in patients with severe mucosa injury. For reflux esophagitis which relapses several times, take 1 tablet (10 mg), once daily.
For non-erosive gastroesophageal reflux disease: In general, for adults, take 1 tablet (10 mg of the active ingredient) at a time, once daily. Duration of taking the medicine is up to 4 weeks.
For helping to eradicate Helicobacter pylori bacteria: In general, for adults, take 1 tablet (10 mg of the active ingredient) at a time, twice daily, for 7 days, concomitantly with amoxicillin hydrate and clarithromycin. If this treatment resulted in failure, take 1 tablet (10 mg) at a time, twice daily, for 7 days, concomitantly with amoxicillin hydrate and metronidazole.
In any case, strictly follow the instructions.
•Swallow the tablet without chewing or crushing.
•If you miss a dose, take a dose as soon as possible when you remember that you missed a dose. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
•If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
• Possible adverse reactions to this medicine
The most commonly reported adverse reactions include rash, hives, itching sensation, diarrhea, abdominal pain, abdominal bloating and constipation. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•breathing difficulty, hives, dizziness [shock, anaphylaxis]
•fever, anemia, gum bleeding, subcutaneous bleeding [pancytopenia, agranulocytosis, thrombocytopenia, hemolytic anemia]
•nausea, vomiting, decreased appetite, yellowing in the skin or white of the eye [fulminant hepatitis, hepatic dysfunction, jaundice]
•fever, widespread red rash, erosion in the eye, mouth or genitalia [toxic epidermal necrosis, Stevens-Johnson syndrome, erythema multiforme]
•decreased urine output, edema, fever [acute renal failure, interstitial nephritis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
•Discard the remainder. Do not store them.
Kaken Pharmacetical Co.,LtdInternal
Revised: 4/2016
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
http://www.info.pmda.go.jp/go/pack/2329028F2224_1_06/