HumatroPen® Injection(生长激素)
HumatroPen is designed to provide flexibility and accuracy in dosing through wide dose ranges and fine dose increments. To help you select which Pen may be appropriate for your patient, use the chart below to view dose ranges and dose increments for each Pen. Each patient or the patient's parent or guardian must carefully read the HumatroPen User Manual before using the HumatroPen (see links in the left column).
After calculating the appropriate dose, locate that dose in the columns below and then look to the far left to determine the number of doses that a single cartridge may provide. This can help you prescribe the appropriate number of cartridges and let you inform patients how often they will need to change the cartridge in their Pen.
*The number of doses provided by a cartridge within this dose range is limited to 28 because a reconstituted cartridge is stable for 28 days when refrigerated.
The 6 mg cartridge may be more appropriate in this dose range.
The 12 mg cartridge may be more appropriate in this dose range.
Injection site should be rotated to avoid tissue atrophy. Patients should be informed that local or systemic allergic reactions may occur and that prompt medical attention should be sought in such cases.
Humatrope cartridges must be refrigerated before and after reconstitution.
Humatrope cartridges should not be used if the patient is allergic to metacresol or glycerin, which are components of the Diluent for Humatrope.
Vial Option
•Humatrope is available in a 5 mg vial.
•Each vial is supplied in a combination package with an accompanying 5 mL vial
of diluent.
•If sensitivity to the Diluent for Humatrope should occur, the vials may be reconstituted with Bacteriostatic Water for Injection (Benzyl Alcohol preserved), United States Pharmacopoeia (USP) or Sterile Water for Injection, USP.
•When Humatrope is reconstituted with Bacteriostatic Water for Injection, USP, the solution should be kept refrigerated at 36° to 46°F (2° to 8°C) and used within 14 days.
•It is important to note that benzyl alcohol used as a preservative in Bacteriostatic Water has been associated with toxicity in newborns. Therefore, Bacteriostatic Water for Injection must not be used to reconstitute Humatrope for use in a newborn infant. When Humatrope is to be administered to a newborn infant, it should be reconstituted with the diluent provided or, if the infant is sensitive to the diluent, Sterile Water for Injection, USP.
•When reconstituted with Sterile Water for Injection, the solution should be kept refrigerated at 36° to 46°F (2° to 8°C) and used within 24 hours. Use only 1 dose per Humatrope vial and discard the unused portion.
http://www.humatropehcp.com/Pages/device-options.aspx
部分中文HumatroPen®处方信息（仅供参考）
[作用与用途]
本品具有与人体生长激素同等的作用，即能促进骨骼、内脏和全身生长，促进蛋白质合成，影响脂肪和矿物质代谢，在人体生长发育中起着关键性作用。皮下注射约80％被吸收，5小时后达高峰血浓度，t1/2约4小时。主要用于内源性脑垂体生长激素分泌不足而引起的生长障碍、躯体矮小的侏儒症、短小病患儿。此外，尚可用于治疗烧伤、骨折、创伤、出血性溃疡、组织坏死、肌肉萎缩症、骨质疏松等疾病。
[用法与用量]
本品给药剂量个体差异很大，采用肌内注射或皮下注射，一般用量为每周0．5—0．7单位／kg或每周12单位／m2，分6—7次给药。
[注意事项]
偶可引进皮肤过敏、注射部位发红和皮下脂肪萎缩、氨基转移酶升高、呕吐及腹痛等。
1．肿瘤患者、糖尿病患者、颅内进行性损伤者禁用。
2，对脑肿瘤的垂体抹儒病者、心脏或肾脏病者、孕妇和哺乳妇女等慎用。
3．使用前，需对脑垂体功能作详细检查，准确诊断后才能应用。
4．应临用时配制，用注射用水溶解，轻轻摇动，切勿振荡，以免变性。
[贮藏] 2℃-8℃保存。有效期为1．5年。
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产地国家: 美国
原产地英文商品名:
HumatroPen for injection 6MG/CARTRIDGE/BOX
原产地英文药品名:
somatropin [rDNA origin] for injection
中文参考商品译名:
HumatroPen 6毫克/药筒/盒
中文参考药品译名:
生长激素
生产厂家中文参考译名:
礼来
生产厂家英文名:
Lilly
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产地国家: 美国
原产地英文商品名:
HumatroPen for injection 12MG/CARTRIDGE/BOX
原产地英文药品名:
somatropin [rDNA origin] for injection
中文参考商品译名:
HumatroPen 12毫克/药筒/盒
中文参考药品译名:
生长激素
生产厂家中文参考译名:
礼来
生产厂家英文名:
Lilly
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产地国家: 美国
原产地英文商品名:
HumatroPen for injection 24MG/CARTRIDGE/BOX
原产地英文药品名:
somatropin [rDNA origin] for injection
中文参考商品译名:
HumatroPen 24毫克/药筒/盒
中文参考药品译名:
生长激素
生产厂家中文参考译名:
礼来
生产厂家英文名:
Lilly