英文药名：GLUBES Combination Tab（Mitiglinide Calcium Hydrate/Voglibose） 中文药名：米格列奈钙/伏格列波糖复方片 生产厂家：KISSEI药品 药品介绍 商標名 GLUBES Combination Tab 一般名 ミチグリニドカルシウム水和物（Mitiglinide Calcium Hydrate) (JAN) 化学名 (+)-Monocalcium bis[(2S,3a,7a-cis)-α-benzylhexahydro-γ-oxo-2-isoindolinebutyrate]dihydrate 分子式 C38H48CaN2O6・2H2O 分子量 704.91 構造式 性状 米格列奈钙水合物是一种白色粉末。它是易溶于甲醇或乙醇（99.5），是略溶于水，极微溶于乙腈。 一般名 ボグリボース（Voglibose）（JAN） 化学名 3,4-Dideoxy-4-[2-hydroxy-1-(hydroxymethyl)ethylamino]-2-C-(hydroxymethyl)-D-epi-inositol 分子式 C10H21NO7 分子量 267.28 構造式 性状 伏格列波糖是一种白色晶体或结晶粉末。这是非常易溶于水，可溶于乙酸（100），略溶于甲醇，极微溶于乙醇（99.5）。可溶于0.1mol / L的盐酸的试剂。 操作注意事项 该代理有时看到数位板表面红色斑点，它是通过使用染料 适应症 2型糖尿病 剂量和给药方法 成人每天给药三次，每顿口服一粒（10毫克/0.2mg的作为米格列奈钙水合物/伏格列波糖）。 包装规格 Gurubesu组合片剂：100片（PTP） Gurubesu组合片剂：210片（PTP） Gurubesu组合片剂：500片（PTP） Gurubesu组合片剂：片剂1050（PTP 生产厂商 KISSEI药品有限公司 完整处方资料附件：http://www.info.pmda.go.jp/go/pack/3969102F1020_1_05/ グルベス配合錠 GLUBES Combination Tab，米格列奈钙/伏格列波糖复方片.（Voglibose+Mitiglinide Calcium Hydrate） Brand name : GLUBES Combination Tab. 　Active ingredient: Mitiglinide calcium hydrate  Voglibose 　Dosage form: pale red tablet, major axis: 10.0 mm, minor axis: 5.0 mm, thickness 3.0 mm 　Print on wrapping: グルベス配合錠 糖尿病用薬 MV 食直前に服用 GLUBES Effects of this medicine This medicine stimulates insulin secretion, and by blocking the enzyme α-glucosidase that degrades carbohydrates to glucose, delays glucose absorption from the small intestine which enables it to control the elevation of blood-glucose level after meal (postprandial hyperglycemia) and improve glycemic control. It is usually used to treat type 2 diabetes. Before using this medicine, be sure to tell your doctor and pharmacist •If you have ever experienced any allergic reaction (itch, rash etc.) to any medicine. If you are a patient with ketosis, diabetic coma or precoma, type 1 diabetes, infection, hepatic or renal dysfunction, heart disease, undergone a laparotomy, experienced bowel obstruction, Roemheld syndrome, intestinal disorder, pituitary gland malfunction, adrenal gland dysfunction or gastrointestinal disorder. If you are in pre/postoperative period. If you are injured, starving, state of malnutrition or debility, or an alcohol consumer. If you engage in intense muscular exercise. •If you are pregnant or breastfeeding. •If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.) Dosing schedule (How to take this medicine) •Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>> •General dosage regimen: For adults, take 1 tablet at a time, 3 times a day, just before (within 5 minutes) meals. Strictly follow the instructions of your doctor/pharmacist. •If you have already started meal, skip the missed dose and continue your regular dosing schedule. DO NOT take double doses to make up for the missed dose. •If you took too much of the medicine (more than ordered), check with your doctor/pharmacist. •Do not stop taking the medicine without the instructions of your doctor. Precautions while taking this medicine •Strictly adhere to dietary instructions given and to kinesitherapy prescribed. •The medicine may cause you to have hypoglycemic symptoms such as dizziness or light-headedness. Pay attention when you drive, work at heights, or operate dangerous machinery while taking it. •If you have hypoglycemic symptoms, take glucose not sucrose or something containing enough glucose such as soft drink. Possible adverse reactions to this medicine Common side effects are reported as below. If any of them occurs, check with your doctor/pharmacist: symptoms of hypoglycemia, enlarged feeling of abdomen, numbness, abdominal pain, increased flatus, weight increase, etc. The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately. •pressured feeling or constrictive pain in chest, cold sweat [myocardial infarction] •dizziness, abnormal craving for food, tremor in limbs [hypoglycemia] •abdominal distension,meteorism, increased flatus[bowel obstruction] •general malaise, loss of appetite, yellowing of skin or conjunctiva [fulminant hepatitis, hepatic dysfunction, jaundice ] •constipatin, faint consciousness, jadgment failure[disturbance of consciousness due to exacerbation of heperammonemia in patients with liver cirrhosis] The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above. Storage conditions and other information •Keep out the reach of children. Store away from direct sunlight heat and moisture. •Discard the remainder. Do not store them.