英文药名：Nasea OD Tablets（Ramosetron Hydrochloride）

中文药名：盐酸雷莫司琼口腔崩解片

生产厂家：安斯泰来制药
治疗类别名称
5-HT3受体拮抗剂的止吐剂（盐酸雷莫司琼口腔崩解片）
一般名
ラモセトロン塩酸塩（Ramosetron Hydrochloride）
化学名
(－)-(R )-5-[(1-Methyl-1H -indol-3-yl)carbonyl]-4,5,6,7-tetrahydro-1H -benzimidazole monohydrochloride
構造式

分子式
C17H17N3O・HCl
分子量
315.80
性状
盐酸雷莫司琼是一种白色至结晶的细带黄白色的粉末。它易溶于水或甲醇，稍少溶于乙醇（99.5）。具有吸湿性。
操作注意事项
注意：
（1）相比于使用不适合的[常规片剂自动包装机的药物是软]
（2）该产品一直由内袋的高耐湿性保持质量
药效药理
1. 药理作用
（1）5-HT 3受体拮抗作用
在血清素诱导的收缩实验10分离的豚鼠结肠），它表现出了有效的和选择性5-HT3受体拮抗作用。此外，大鼠）和雪貂血清素诱导的心动过缓反射）（的Bezold - 在Jarisch反射）的实验，表现出强烈的和持久的5-HT3受体拮抗作用通过口服给药。
（2）抗肿瘤剂引起的呕吐的抑制作用
对呕吐顺铂诱导的雪貂表现出抑制作用口服，持续效果是有效。
2. 作用机序
抗肿瘤剂如顺铂，以从胃肠道的肠嗜铬细胞释放的血清素。此血清素结合到存在于胃肠道粘膜上5-HT 3受体的传入迷走神经末梢的刺激以诱导通过呕吐中枢呕吐。盐酸雷莫司琼被认为是通过阻断5-HT 3受体表达止吐作用。
适应证
用于癌症化疗(如使用顺铂治疗)引起的恶心、呕吐等消化道症状。
用法用量
口服给药：每次0.1mg，每天1次，于化疗药物给药前1h服用。必要时可根据年龄、症状酌情增减。
包装
0.1mg*10錠（1錠×10）

生产商
安斯泰来制药公司
Nasea OD Tablets（Ramosetron hydrochloride）
Nasea OD Tablets 0.1mg（ナゼアOD錠0.1mg）
Brand name : Nasea OD Tablets 0.1mg
　Active ingredient: Ramosetron hydrochloride
　Dosage form: light reddish-yellow (on the curved side) and dark reddish-yellow (on the plain side) tablet (φ: 8.5mm, thickness: 4.0mm)
　Print on wrapping: (Face) Nasea OD 0.1mg, house-mark + 405, 0.1mg, (Back) ナゼアOD 0.1mg
Effects of this medicine
This medicine acts on the serotonin receptors and relieves gastrointestinal symptoms such as nausea, vomiting, etc.
It is usually used for the treatment of gastrointestinal symptoms (nausea and vomiting) associated with the administration of anticancer drugs.
Before using this medicine, be sure to tell your doctor and pharmacist
If you ever experienced any allergic reaction (itch, rash etc.) to any medicine.
If you are pregnant or breastfeeding.
If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
General dosage regimen: For adults, take 1 tablet (0.1mg of the active ingredient) at a time, once daily. The dosage may be adjusted according to the patient's age and symptoms. Strictly follow the instructions of your doctor/pharmacist.
This medicine can be taken without water, only with saliva. When it is taken only with saliva it must be swallowed together with the saliva.
If you have missed a dose, take the missed dose as soon as possible.
DO NOT take double doses to make up for the missed dose.
If you took too much of the medicine (more than ordered), check with your doctor/pharmacist.
Do not stop taking the medicine without the instructions of your doctor.
Broken or chipped tablets: Tablets may be broken or chipped. However, the effect of the tablet is unaffected. Take the entire prescribed amount of the medicine including the broken or chipped parts.
This medicine is easily broken. Do not use your fingernails and push the sheet using the ball of your finger when you remove the tablet from the sheet.
Precautions while taking this medicine
Possible adverse reactions to this medicine
Common side effects are reported as below. If any of them occurs, check with your doctor/pharmacist: skin eruption, headache/heaviness of the head, fever, etc.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
pallor facial, cold sweat, dizziness on standing up  [shock, anaphylactoid symptoms]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
Keep out of the reach of infants and children. Store away from direct sunlight, heat and humidity.
Discard the remainder. Do not store them. Consult with your dispensing pharmacy when you discard the medicine.
Astellas Pharama Inc. Internal
Revised: 11/2006
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
http://www.info.pmda.go.jp/go/pack/2391004F1024_1_15/2391004F1024_1_15?view=body#20