英文药名：Myocor spray（Nitroglycerin）

中文药名：硝酸甘油舌下喷雾

生产厂家：TOA EIYO LTD
治疗类别名称
计量硝酸甘油舌下喷雾
欧文商標名
Myocor spray 0.3mg
一般名：ニトログリセリン(Nitroglycerin)
化学名：Glyceryl trinitrate又は1,2,3-Propanetriol trinitrate
分子式：C3H5N3O9
分子量：227.09
構造式：

性状：
硝酸甘油是一种无色液体透明粘稠在室温下，味道是甜的灼热感，受到撞击爆炸。
药效药理
1.血流动力学的作用
1个，2个或3个喷这种药物清醒狗的舌下，降低立即剂量依赖性的收缩压的喷雾后，观察到减少和增加脉压的心脏速率。
2.冠状动脉扩张作用
当该药物在缺血性心脏疾病的患者分别为1或2喷涂时，观察到相比于非给药组扩展显著冠状动脉直径。
3.运动耐受剂量的增加效应
在将要进行劳力型心绞痛，这种药物一喷安慰剂相比，平板运动试验显著时间的延长从药物施用到运动完。
适应病症
心绞痛发作缓解
用法与用量
成人给药：一次喷涂（0.3mg的硝化甘油）舌下。在不足添加效果的情况下管理一个喷雾。
（使用法）
在使用这种药物，它以获得足够的效果，正确使用是很重要的。
(1)推开上盖。
(2)如果您想使用的第一次，是在制成的容器的状态空喷6-7次。另外，当不使用一段时间（约1个月），或当它被存储和移动在一个倒立状态，或横向，在几个空喷涂在站在使用足够的液体药物容器之前的状态的确认你出来，你要使用。
(3)关闭喷射孔尽可能到口（直到手指与连接到颚的容器）。如果剩余量小，因为它可能不准确喷洒有倾斜，优选的容器必须是直立。另外，你想从一个名不见经传使用它造成的头部，如果你正在睡觉。

図．ミオコールスプレー0.3mgの噴霧例
(4) 抬起舌头，张开嘴，并从戴在下巴，喷雾按钮按一次向舌下（舌头后面）的状态下，呼吸，关闭嘴。在这种情况下，它没有深深地吸入。
(5) 使用完毕后，关闭顶盖。
（请求医生，药剂师等）
患者在伴随耐心的指导（到谁正在使用宇达电通呼叫喷0.3mg的人）的内容描述，街货量会给你永远的文档。另外，请指导，从而保护了严格的剂量和服药。
包装规格
喷雾为：0.3mg（7.2克，100次）1本　5本
生产商
Toaeiyo有限公司
包装规格
喷雾为：0.3mg（7.2克，100次）1本　5本

生产商
安斯泰来制药公司
Myocor spray 0.3mg（Nitroglycerin）
Myocor spray 0.3mg（ミオコールスプレー0.3mg） 
Brand name : Myocor spray 0.3mg
　Active ingredient: Nitroglycerin
　Dosage form: metered-dose sublingual spray, diameter 22 mm, height approx. 78mm
　Print on wrapping: 
Effects of this medicine
This medicine has vasodilatory effects on coronary arteries to increase blood flow. These effects improve the transport of both oxygen and nutrition into cardiac cells and reduce systemic vascular resistance, arterial pressure and workload in the heart.
This medicine is to be used for the acute relief of angina attacks.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have hypotension, angle-closure glaucoma, head trauma, cerebral hemorrhage, or anemia.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•In general, for adults, one spray (containing 0.3 mg of nitroglycerin) should be administered under the tongue. If there is no improvement in symptoms after about 3 minutes, at most one additional spray is allowed. Strictly follow the instructions.
•At the onset of an attack, if possible before using the spray, find somewhere to sit down, hold the container vertically close to your mouth and then spray toward the sublingual region (underside of the tongue) while holding your breath.
•Before this product is used for the first time, the pump must be sprayed into the air 6 or 7 times while the container is held upright (This is known as priming). When priming the container, actuate the spray into the air away from yourself and others. If the spray has not been used for more than one month, or if the container has been stored or carried either horizontally or upside down, before use, confirm whether a sufficient amount of drug solution is released after priming.
•If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
•Alcohol may enhance the vasodilatory effect and cause hypotension.
•Headache, as a side effect, may impair your attentiveness, concentration and/or reflexes. If you feel these symptoms, avoid operating a motor vehicle or machinery.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include headache, tongue numbness/irritation/pain and rash. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
No pertinent entries.
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep this medicine out of the reach of infants and children. Store away from direct sunlight, heat (40 degrees Celsius (104 degrees Fahrenheit) or more) and fire.
•Keep or carry this medicine preferably upright in a location where you can use it immediately.
•Medicine that has been used more than the number of spray applications shown on the container label or which is beyond its expiration period must be discarded. DO NOT keep it. To dispose of this medicine, follow the appropriate method described in the attached information for patients.
TOA EIYO LTD.External
Revised: 11/2014
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
http://www.info.pmda.go.jp/go/pack/2171701R4038_1_05/