英文药名：Meditranstape(Nitroglycerin) 中文药名：硝酸甘油贴剂 生产厂家：协和发酵麒麟 メディトランステープ27mg 治疗类别名称 心脏疾病的透皮治疗剂 商標名 Meditranstape 一般名 ニトログリセリン　Nitroglycerin 化学名 Glyceryl trinitrate又は1,2,3-Propanetriol trinitrate 分子式 C3H5N3O9 分子量 227.09 化学構造式 性状 硝酸甘油是一种无色透明粘稠液体，在常温下，味道甜美，烧灼感。 操作注意事项 病人经过而这种药物的内袋（铝袋包装）的，并指示将其从内料袋使用这种药物时除去。 作用与用途 为速效、短效硝酸酯类抗心绞痛药物。其作用是直接松弛血管平滑肌，特别对小血管平滑肌，使全身血管扩张，外周阻力减少，血压下降，静脉回心量减少，心排血量降低，从而降低心肌耗氧量。此外尚有促进侧支循环的作用和对其他平滑肌的松驰作用。 主要用于缓解心绞痛的发作，亦用于支气管哮喘、肢端动脉痉挛、肾纹痛、胆绞痛、视网膜中央动脉栓塞等。 用法与用量 成人；每天一次（27mg含硝酸甘油）胸椎，腰椎，上臂之一。在效果不足的情况下，增加到二次。 包装规格 27毫克：70枚（1枚×70）、140枚（1枚×140）、350枚（1枚×350） 生产厂家 协和发酵麒麟 完整处方附件：http://www.info.pmda.go.jp/go/pack/2171701S7063_3_01/ Therapeutic category name Transdermal-therapeutic agent for heart disease Brand Name Medi transformer tape 27mg composition Active ingredient - content Nitroglycerin 27mg Additive Sun station cetanol, 2-ethylhexyl methacrylate, 2-ethylhexyl, dodecyl methacrylate acrylate copolymers, ethyl acetate Contraindication There is a risk to further worsen the symptoms to reduce the blood pressure by severe hypotension or patients with cardiogenic shock [vasodilator action] Which may increase the patient [intraocular pressure in angle-closure glaucoma] There is a possibility to increase the patient [intracranial pressure with a head injury or brain hemorrhage] Advanced anemia symptoms by the patient [decrease in blood pressure with anemia (dizziness, lightheadedness, etc.) there is a possibility that exacerbate] Patients with a history of hypersensitivity to nitric acid, nitrous acid ester-based drug Agents with phosphodiesterase 5 inhibitory effect (sildenafil citrate, vardenafil hydrochloride hydrate, tadalafil) patients in the administration the "Important Precautions", see the section of "interaction"] Efficacy or effect Angina pectoris Since this drug is not suitable for therapies aimed at seizure remission of angina, the use of fast-acting nitrate-nitrite system agent for this purpose. Usually, it stuck one once a day for adults (27mg containing as nitroglycerin) thoracic, lumbar, in one of the upper arm. In the case of the effect insufficient is increased to two. Careful administration There is a possibility to further lower the blood pressure of low blood pressure patients [vasodilating action] Patients' cardiac output of primary pulmonary hypertension is reduced, there is a risk of shock] Brought the enhancement of patient [ventricular pressure hidden of hypertrophic obstructive cardiomyopathy, there is a fear that worsen the symptoms] Pharmacology GTN heart (nitroglycerin), action 10 to the vascular system) In healthy adult male, the heart of GTN, the effects on the vascular system, was examined by ultrasound tomography changes in the M-mode echocardiography and inferior vena cava lumen. Lower vena cava Index showing the venous return, the redistribution of the blood due to an increase in the vein of compliance to the peripheral is shown, the inferior vena cava lumen showed a reduction. In addition, left atrial dimension, reduced left ventricular end-diastolic diameter and the like, before the load reduction effect was observed. These hemodynamic various indicators was well correlated with the GTN concentration in plasma. Pulse pressure lowering effect Dosage form size change before formulation 2, 4 and 8 sheets/by dog ​​transdermal administration (54,108 and 216mg / dog transdermal administration as GTN), dose-dependent pulse pressure lowering effect was observed. Pulse pressure decrease action lasts 1-24 hours after administration was compared to a significant reduction in the placebo group. Plasma GTN concentration measured at the same time was maintained for 24 hours. GTN from the blood when you peel this drug to 24 hours after the administration was promptly disappeared, also, pulse pressure lowering effect was restored to almost the same extent as the placebo group. Effects on cardiovascular function By transdermal administration of 5, 10 and 20mg / kg as GTN to anesthesia thoracotomy dog, pulmonary artery wedge pressure, reduce the left heart pressure and aortic pressure, also to reduce the afterload on the heart, the improvement of cardiac function effect was observed. Effects on myocardial blood flow distribution in the ischemic heart For experimental ischemic heart that was created by adding a constriction in the anterior descending proximal portion under the front left coronary artery of anesthesia thoracotomy dog, in the transdermal administration of GTN of 5mg / kg, the blood of significant myocardial inner side of ischemia It showed an increased effect on the flow, improved myocardial blood flow distribution. Action against ST · T excursion was experimentally induced Coronary artery ligation in dogs, cardiac pacing load in the high-cholesterol diet breeding rabbits, for ST · T deviation on the electrocardiogram, which is caused by vasopressin or adrenaline such as administration in the rat, GTN represents a significant suppression, oxygen in the heart muscle It showed an improvement effect of balance demand. In addition, the effect also by two weeks of continuous use changes were not observed. Physicochemical knowledge of active ingredient Behavior Nitroglycerin is at ambient temperature in a viscous liquid of colorless and transparent, the taste is sweet and burning sensation.