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AMINOLEBAN Injection（Amino acid/氨基酸注射液）-为慢性肝功能衰竭最新治疗药
类别名称
肝性脑病改善氨基酸注射液
商標名
AMINOLEBAN Injection
组成
这种药物含有在1包（50克）以下的成分和数量。
- 异亮氨酸1.9225克
L-亮氨酸2.037克
L-赖氨酸盐酸盐0.2425克
L-苏氨酸0.133克
L-缬氨酸1.602克
L-精氨酸盐酸盐0.302克
L-组氨酸盐酸盐0.1875克
L-色氨酸73.5mg
明胶水解物6.5克
米面油3.5克
糊精31.05克
维生素A棕榈酸酯466I.U.
钙化醇46.6IU
双苯酰硫胺0.145mg
核黄素0.155mg
盐酸吡哆辛0.245mg
氰钴胺素为0.5μg
叶酸为50μg
钠L-抗坏血酸为6.9mg
醋酸生育酚9.3mg
植物甲萘醌5.5μg
泛酸钙1.19mg
烟酰胺1.515mg
生物素为25μg
酒石酸氢胆碱12.3mg
硫酸镁水合物0.205克
甘油磷酸钙0.305克
磷酸二氢钠0.195克
柠檬酸钠铁12.5毫克
硫酸铜0.515mg
硫酸锌水合物3.755mg
碘化钾12.5μg
硫酸锰0.815mg
氯化钾0.1875克
酪朊酸钠作为添加剂，山梨酸钾，纯化蔗糖，含有索马甜，硅酮树脂，蔗糖脂肪酸酯。
禁忌
病人:过敏的牛奶（这剂含有酪蛋白作为添加剂）
功效或效果
慢性肝功能衰竭患者的肝性脑病的营养状况改善
一般，口服摄取用一次1包（50克）溶解在约水或温水180ML（约200kcal/200ml）中，每日3次的膳食的成年人的量。
该剂量可以适当地根据患者的年龄和症状进行调整
制备方法
如果要制备Aminoleban EN配制分散液1包（50克）至约1kcal/毫升，置于约180毫升的水或温水（约50℃）的容器中，并溶解，加入1包分布式Aminoleban EN共混。在这种情况下，溶解后的液体体积为约200毫升（约1kcal/毫升）。
临床上显著的不良反应
低血糖
小于0.1％
低血糖（冷汗，感觉不好，颤抖，心悸等），因为它可能会出现，采取这种症状的情况下，适当的措施。
药效药理
1. 门静脉被用作肝性脑病模型 - 在下腔静脉吻合术的大鼠，在血浆和大脑中的费歇尔比是正确的，脑单胺代谢异常已被归一化。此外，睡眠 - 觉醒节律异常也得到了改善。
2. 氨门静脉加载 - 在下腔静脉吻合术的大鼠，在血浆和大脑中的费歇尔比是正确的，降低血中氨值，改善脑单胺的代谢和脑电波。
包装规格
200毫升*20袋软袋
500毫升*20袋软袋
生产厂商
大冢制药有限公司
注：以上中文仅参考，使用以原文为准：http://www.info.pmda.go.jp/go/pack/3253404A3055_1_06/
AMINOLEBAN Injection（Amino acid）
AMINOLEBAN Injection (200 mL)（アミノレバン点滴静注（200mL））
Brand name : AMINOLEBAN Injection (200 mL)
Active ingredient: Amino acid
Dosage form: injection
Print on wrapping:
AMINOLEBAN Injection (500 mL)（アミノレバン点滴静注（500mL））
Brand name : AMINOLEBAN Injection (500 mL)
Active ingredient: Amino acid
Dosage form: injection
Print on wrapping:
Effects of this medicine
This medicine is an injection consisting of specific amino acid composition to improve encephalopathy that may occur in patients with chronic liver disease.
It is usually used to treat encephalopathy (consciousness disturbance, memory impairment, language disorder, swaying feeling, or convulsion) that may develop in patients with chronic liver disease.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
•If you have; renal impairment, amino acid metabolism abnormality, acidosis, or congestive heart failure.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•This medicine is usually administered by intravenous (IV) drip infusion. Please ask your doctor for details regarding duration of administration.
Precautions while taking this medicine
• Possible adverse reactions to this medicine
Reported adverse reactions include nausea, headache, and angialgia (pain in a blood vessel at an injection site). If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•chills, palpitations, feelings of weakness [hypoglycemia]
•consciousness disturbance, flapping tremor of hands (tremulousness) [hyperammonemia]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Otsuka Pharmaceutical Factory Inc.Injection
Published: 12/2013
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
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