英文药名：TAIPROTON Cap（Lansoprazole）

中文药名：兰索拉唑胶囊

生产厂家：武田Teva制药

タイプロトンカプセル15mg／タイプロトンカプセル30mg

治疗类别名称
质子泵抑制剂
商標名
TAIPROTON Cap
一般名
ランソプラゾール、Lansoprazole（JAN）
化学名
(RS)-2-({[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl}sulfinyl)benzimidazole
分子式
C16H14F3N3O2S
分子量
369.36
構造式

性状
白色到带褐色的白色结晶粉末。
N，N-二甲基甲酰胺，以更可溶，略溶于甲醇，微溶于乙醇（99.5），并且几乎不溶于水。
N的产物，N-二甲基甲酰胺溶液（1→10）示出了没有旋光性。
熔点
约166℃（分解）
操作注意事项
稳定性试验
使用结果的最终包装产品（40℃，相对湿度75％，6个月）加速试验，泰国质子胶囊15毫克和泰国质子胶囊30毫克，据估计，在正常的市场分布3年的稳定性。
适应病症
<兰索拉唑胶囊15毫克>
○胃溃疡，十二指肠溃疡，吻合口溃疡，反流性食道炎，佐林格 - 埃利森综合征，非糜烂性胃食管反流病，在给药时间在低剂量阿司匹林给药，非甾体抗炎药的时间胃溃疡或十二指肠溃疡复发抑制胃溃疡或十二指肠溃疡复发抑制
○根除幽门螺杆菌的辅助
胃溃疡，十二指肠溃疡，胃MALT淋巴瘤，特发性血小板减少性紫癜，胃早期胃癌后内镜治疗，幽门螺杆菌感染性胃炎
<兰索拉唑胶囊30毫克>
○胃溃疡，十二指肠溃疡，吻合口溃疡，反流性食道炎，佐林格 - 埃利森综合征
○根除幽门螺杆菌的辅助
胃溃疡，十二指肠溃疡，胃MALT淋巴瘤，特发性血小板减少性紫癜，胃早期胃癌后内镜治疗，幽门螺杆菌感染性胃炎
用法用量
○胃溃疡，十二指肠溃疡，吻合口溃疡，在佐林格 - 埃利森综合征
每天一次，每次服30毫克。通常，胃溃疡，长达8周在吻合口溃疡，长达6周的十二指肠溃疡。
○返流性食管炎
每天一次，每次服30毫克。应当指出的是，通常可达至8周的施用。
另外，在反流性食道炎重复复发或复发的维持疗法，虽然口服每日一次给药一次15毫克，在效果不充分的情况下，30毫克，每天一次，可以口服给药。
○非糜烂性胃食管反流病（兰索拉唑胶囊15毫克只）
每天一次，每次服15毫克。应当指出的是，通常最多4周的给药。
○胃溃疡或十二指肠溃疡复发抑制在低剂量阿司匹林给药的时间的情况下（兰索拉唑胶囊为15mg）
每天一次，每次服15毫克。
○非甾体抗炎药胃溃疡或十二指肠溃疡○复发抑制给药期间（兰索拉唑胶囊为15mg）
每天一次，每次服15毫克。
○幽门螺杆菌根除的辅助
30毫克1次作为兰索拉唑为成人，一次将750mg（效价），为阿莫西林水合物，一次作为克拉霉素200毫克的三种药物同时（效价），一天两次，口服给药7天。此外，克拉霉素如果需要可以增加。然而，一日两次400毫克，每天（效价）和上限。
质子泵抑制剂，如果由阿莫西林水合物和克拉霉素的三药物施用根除治疗幽门螺杆菌是不成功的，因为治疗性替代此，通常，一旦30毫克，阿莫西林水作为成人兰索拉唑一旦将750mg（效价），一次同时三种药物两次250毫克一天甲硝唑作为水合物，7天口服给药。
药效药理
兰索拉唑，抑制质子泵抑制剂胃酸分泌，是在酸性条件下激活的前药。从血管进入胃酸分泌细胞（壁细胞），在小区中的酸分泌细胞积累，因为它是一种弱碱。此后，通过在壁细胞，H +的酸活化，被认为通过抑制K + -ATP酶抑制胃酸的分泌。
包装规格
胶囊
15毫克
100粒（PTP10胶囊×10）500粒（PTP10胶囊×50）700粒（PTP14胶囊×50）
500粒（瓶）

30毫克
100粒（PTP10胶囊×10）30毫克500粒（PTP10胶囊×50）30毫克700粒（PTP14胶囊×50）500粒（瓶）

制造商
武田Teva制药有限公司
TAIPROTON Cap（Lansoprazole）
TAIPROTON Cap.15mg（タイプロトンカプセル15mg）
Brand name : TAIPROTON Cap.15mg
　Active ingredient: Lansoprazole
　Dosage form: white capsule, major axis: 14 mm, minor axis: 6.5 mm
　Print on wrapping: (face) TAIPROTON15mg TYK395 15mg, (back) タイプロトン 15mg TYK395
TAIPROTON Cap.30mg（タイプロトンカプセル30mg）
Brand name : TAIPROTON Cap.30mg
　Active ingredient: Lansoprazole
　Dosage form: white capsule, major axis: 18 mm, minor axis: 7.5 mm
　Print on wrapping: (face) TAIPROTON30mg TYK396 30mg, (back) タイプロトン 30mg TYK396
Effects of this medicine
This medicine inhibits enzyme activities of the proton pump in the gastric mucosa and suppresses gastric acid secretion.
It is usually used in the treatment of gastric ulcer, duodenal ulcer, anastomotic ulcer, reflux esophagitis and Zollinger-Ellison syndrome.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have: hepatic disorder.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<        to be written by a healthcare professional>>
•For gastric ulcer, duodenal ulcer, anastomotic ulcer, reflux esophagitis and Zollinger-Ellison syndrome: In general, for adults, take 1 capsule (30 mg of the active ingredient) at a time, once daily. The duration of administration is restricted to 8 weeks for gastric ulcer and anastomotic ulcer, and 6 weeks for duodenal ulcer.
For reflux esophagitis: In general, for adults, take 1 capsule (30 mg) at a time, once daily. The duration of administration is restricted to 8 weeks. In maintenance therapy for recurrent or relapse reflux esophagitis, take 15 mg at a time, once daily. If the therapeutic effect is insufficient, you may be instructed to take 1 capsule (30 mg) at a time.
The dosage may be adjusted according to the disease, age or symptoms in any case. Strictly follow the instructions.
•If you miss a dose, take a dose as soon as you remember. However, you need to wait longer than 8 hours to take the next dose. You should never take two doses at one time.
•If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
• Possible adverse reactions to this medicine
The most commonly reported adverse reactions include rash, itch, constipation, diarrhea, dry mouth, enlarged feeling of abdomen, headache, sleepiness, fever and gynecomastia. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•systemic rash, facial edema, breathing difficulty  [anaphylactic reaction, shock]
•general malaise, fever, shortness of breath, nasal bleeding, subcutaneous bleeding, reddish brown urine  [pancytopenia, agranulocytosis, granulocytopenia, hemolytic anemia, thrombocytopenia, anemia]
•yellowing in skin and white of eyes, general malaise, loss of appetite  [serious hepatic dysfunction]
•fever, general malaise, rash or redness in skin, eye or mouth  [toxic epidermal necrolysis, oculomucocutaneous syndrome]
•fever, dry cough, breathing difficulty  [interstitial pneumonia]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
•Discard the remainder. Do not store them.
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