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异克舒令片(Isoxsuprine HCl tablets)

2016-08-07 14:25:36  作者:新特药房  来源:互联网  浏览次数:6  文字大小:【】【】【
简介: 部份中文异克舒令处方资料(仅供参考)【药品名】异克舒令【英文名】IS0xSUprine【别 名】异舒普林,苯氧丙酚胺,DU-VADILAN,VASODILAN【作用与用途】本品具有阻断a受体及激动β受体的作用,也具有直 ...

部份中文异克舒令处方资料(仅供参考)
【药品名】异克舒令
【英文名】IS0xSUprine
【别  名】异舒普林,苯氧丙酚胺,DU-VADILAN,VASODILAN
【作用与用途】
本品具有阻断a受体及激动β受体的作用,也具有直接舒张血管平滑肌及子宫平滑肌的作用。故可舒张脑血管、骨骼肌血管及皮肤血管,也有正性肌力效应。口服后吸收良好。给药后1小时达血药浓度16值。t1/2为1.5小时。
临床用于治疗脑血管及外周血管痉挛性疾病。口服,1次200mg,1日4次;肌注,1次10mg,1日3次。
也可用于防止早产。开始时静脉滴注,200-300μg/分,可视反应渐增至500μg/分。用药时需监护孕妇的血压、心率以及胎儿的心率;随后可肌注,第1天每3小时10mg;第2—3天每4—6小时10mg;然后再续以口服,40-80mg/日,分次服。
【注意事项】
不良反应有瞬时皮肤潮红及胃肠功能失常。大剂量可致心率加快及低血压。罕见皮疹。
近期出血者禁用。心脏病及贫血患者不宜注射给药。伴有感染的早产不宜应用。
【包装规格与生产厂家】
ISOXSUPRINE TB 10MG BI-CO 100  ISOXSUPRINE HCL  42582-0101-10
厂家:BI COASTAL PHARMA INTERN
ISOXSUPRINE TAB 10MG ECI 100  ISOXSUPRINE HCL   51293-0606-01 
厂家:ECI PHARMACEUTICALS LLC


SPL UNCLASSIFIED SECTION
Rx Only
 
DESCRIPTION
Each tablet taken orally contains Isoxsuprine Hydrochloride, USP with the following chemical structure:


C18H23NO3 • HCl
p-Hydroxy-α[1-[(methyl-2-phenoxy-ethyl)amino]ethyl]benzyl alcohol hydrochloride.
Quantitative Ingredient InformationEach tablet taken orally contains 10 or 20 mg Isoxsuprine HCl
Pharmacological ClassPeripheral Vasodilator
INDICATIONS
Based on a review of this drug by the National Academy of Sciences-National Research and/or other information, the FDA has classified the indications as follows:
Possibly Effective1.For the relief of symptoms associated with cerebrovascular insufficiency.
2.In peripheral vascular disease of arteriosclerosis obliterans, thromboangitis obliterans (Buerger's disease) and Raynaud's disease.
Final classification of the less-than-effective indications requires further investigation.
CONTRAINDICATIONS
There are no known contraindications to oral use when administered in recommended doses.
Isoxsuprine Hydrochloride, USP should not be given immediately postpartum or in the presence of arterial bleeding.
PRECAUTIONS
Pediatric UseSafety and effectiveness in pediatric patients have not been established.
ADVERSE REACTIONS
On rare occasion oral administration of the drug has been associated in time with the occurrence of hypotension, tachycardia, chest pain, nausea, vomiting, dizziness, abdominal distress, and severe rash. If rash appears, the drug should be discontinued.
Although available evidence suggests a temporal association of these reactions with Isoxsuprine Hydrochloride, a causal relationship can be neither confirmed nor refuted.
Beta Adrenergic receptor stimulants such as Isoxsuprine Hydrocholoride have been used to inhibit pre-term labor.
Maternal and fetal tachycardia may occur under such use. Hypocalcemia, hypoglycemia, hypotension and ileus have been reported to occur in infants whose mothers received Isoxsuprine Hydrochloride. Pulmonary edema has been reported in mothers treated with beta stimulants. Isoxsuprine Hydrochloride is neither approved nor recommended for use in the treatment of premature labor.
DOSAGE AND ADMINISTRATION
Oral: 10 to 20 mg, three or four times daily.
HOW SUPPLIED
Isoxsuprine HCl tablets, USP 10 mg
Bottles of 100 NDC 42582-100-10
Isoxsuprine HCl tablets, USP 20 mg
Bottles of 1000 NDC 42582-200-20
Isoxsuprine HCl tablets, USP 20 mg
Bottles of 100 NDC 42582-200-10
COMPOSITIONIsoxsuprine HCl 10mg and 20mg tablets: These tablets contain the following inactive ingredients: corn starch, lactose monohydrate, magnesium stearate (vegetable), microcrystalline cellulose.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=47134A96-77D0-4211-90B8-E2A857586D7B

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