欧洲呼吸协会（ERS）年会5日公布的一项研究结果表明，与使用安慰剂进行治疗的轻度慢性阻塞性肺病（简称COPD）患者相比较，使用SPIRIVA（R）（tiotropium）治疗的患者肺部功能有显著的改善。
 
上述研究是一项为期12周的随机、双盲、安慰剂对照研究，涉及224名轻度COPD患者。研究结果显示，与使用安慰剂的患者相比，所有使用SPIRIVA（R）治疗的患者的肺部功能均有显著改善，其中包括1秒用力呼气量（FEV1）和用力肺活量（FVC）两个指标。服用SPIRIVA（R）第一剂后30分钟疗效十分明显，并且这种疗效可维持24个小时，甚至长达12周的研究期。
 
长效吸入型抗胆碱能药物SPIRIVA（R）是一种可明显、持续改善肺部功能的每日一服的吸入型药物。

IMPORTANT SAFETY INFORMATION

Talk to your doctor to see if Spiriva^® HandiHaler^® (tiotropium bromide inhalation powder) is right for you.

SPIRIVA HandiHaler is a prescription medicine used once every day (a maintenance medicine) to control symptoms of chronic obstructive pulmonary disease (COPD) by relaxing your airways and keeping them open. COPD includes chronic bronchitis, emphysema, or both.

SPIRIVA HandiHaler also reduces the likelihood of flare-ups and worsening of COPD symptoms (COPD exacerbations). A COPD exacerbation is defined as an increase or new onset of more than one COPD symptom such as cough, mucus, shortness of breath, and wheezing that requires medicine beyond your rescue medicine.

Do not use SPIRIVA HandiHaler if you are allergic to tiotropium or ipratropium (Atrovent^®). Allergic reactions may include itching, rash, or swelling of the lips, tongue, or throat.

SPIRIVA HandiHaler is not a rescue medicine and should not be used for treating sudden breathing problems.

Do not swallow SPIRIVA capsules. The contents of the capsule should only be inhaled through your mouth using the HandiHaler device.

Stop taking SPIRIVA and get medical help right away if your breathing suddenly worsens, your throat, lips, or tongue swells, you get hives, you have vision changes or eye pain, or you have difficulty passing urine or painful urination.

Tell your doctor if you have glaucoma, problems passing urine, or an enlarged prostate, as these may worsen with SPIRIVA. Tell your doctor if you have kidney problems or are allergic to milk proteins. Ask your doctor if you are not sure. Also discuss with your doctor all the medicines you take, including eye drops.

The most common side effect with SPIRIVA is dry mouth. Others include constipation and trouble passing urine. For a complete list of reported side effects, ask your doctor or pharmacist.

Do not get SPIRIVA powder in your eyes.

Read the Patient Information and the step-by-step Patient's Instructions for Use for SPIRIVA before you take your medicine.

The information provided on this site is for general information and educational purposes only. You should always consult a doctor for diagnosing and treating a health or fitness problem, and before using any drug product discussed on this site. Respiratory symptoms may be due to other diseases that might require different therapies.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Click here for Full Prescribing Information and Patient's Instructions for Use.

Spiriva(Tiotropium Bromide) 是一种与Atroven(Ibetropium Bromide)极相似的呼吸系统用药。它是由欧洲药厂(Boehringer Ingelheim)所发展出来的药，它与一般的Atroven不同处在于它作用在更特别的支气管平滑肌的受器上(Muscarinic receptor M3)，故能更有效的发挥药性，并使其对身体其它器官的副作用降至最低。

Spiriva 的另一项优点是它的药效期长，一天只要使用一次及可，而其它支气管平滑肌松弛剂则需使用3-4次；研究显示，当慢性肺气肿(COPD)或气喘患者使用了Spiriva后，他们使用其它气管扩张剂的次数及剂量都减少了，同时因急性呼吸衰竭而住院的次数也显著降低。

Spiriva在欧洲地区已被使用多年，该药是治疗呼吸疾病的一个不可或缺的药物….。至于副作用方面，Spiriva的主药副作用是会引起口干，舌燥的感觉，但一般病人在长期使用后，副作用都会消失或适应良好。