英文药名: Requip (ropinirole tablets) 中文药名: 罗匹尼罗片 生产厂家: Glaxo Smith Kline 【药品名称】 通用名称:盐酸罗匹尼罗片 0.25mg, 0.5mg, 1mg, 2mg, 5mg 【药理】 【药代动力学】 罗匹尼罗口服吸收迅速,口服后1-2小时达峰。临床试验显示,标记后的罗匹尼罗88%可出现在尿中,其的绝对生物利用度为55%。相对生物利用度为85%。进食对罗匹尼罗的进一步吸收无影响,但Tmax升高为 2.5小时。患者经口给予罗匹尼罗的清除率为47 L/hr,消除半衰期约为 6 小时。罗匹尼罗进一步在肝脏代谢为非活性物质。罗匹尼罗在治疗剂量1 mg- 8 mg,每天三次范围内 ,表现为线性代谢动力学,服药2天后达到稳态。 罗匹尼罗用于自发性帕金森氏病的治疗。 先从低剂量开始逐渐增加到治疗量,可以单独或与食物一起服用。 全身表现:少见-蜂窝织炎、周围水肿、发热、类流感症状、腹部增大、心前区疼痛、非特异性水肿;罕见-腹水。 对本品有过敏反应的患者禁用。 日常活动中易产生困倦:有报道罗匹尼罗治疗的患者在日常活动中(如驾驶车辆时)会出现困倦,而这经常会导致事故的发生。虽然许多患者称服用罗匹尼罗后有嗜睡表现,但并没有过度昏睡的先兆。据报道这些表现也可以到治疗1年后才出现。如果患者在白天日常活动中出现明显的困倦和嗜睡(如谈话、吃饭等),应该停用罗匹尼罗(见剂量和用法部分)。如果决定继续使用罗匹尼罗,患者应避免开车或其它危险的活动。目前还无法确定减少罗匹尼罗剂量就可以消除出现的困倦。 动物试验证实罗匹尼罗可以影响胚胎发育,如致畸胎效应。目前还没有足够的相关研究,故妊娠妇女服用罗匹尼罗应充分考虑到用药风险,权衡利弊。罗匹尼罗能抑制妇女催乳素的分泌从而减少哺乳。大鼠试验显示乳汁中含有罗匹尼罗或它的代谢物,但还不清楚罗匹尼罗是否会通过人乳排泄。由于许多药物都通过人乳排泄,可能会对婴儿造成影响,所以妊娠妇女要考虑是否需要停止哺乳或使用罗匹尼罗。 疗效和安全性尚未确定。 65岁以上患者与65岁以下患者相比,罗匹尼罗的清除率降低30%,但因本药为剂量累加给药,逐渐加量,直到疗效满意而不出现毒副作用为止,故无需调整剂量。 P450作用:体外研究发现CYP1A2是罗匹尼罗代谢过程中起主要作用的酶,服用了CYP1A2的作用底物或抑制剂就会改变罗匹尼罗的清除率,因此停止或使用CYP1A2强效抑制剂时应相应调整罗匹尼罗的剂量。 过量服用引起的症状与罗匹尼罗的多巴胺能作用有关,要采取支持治疗、同时维持生命体征的稳定、清除未吸收成份(如洗胃)。 Drug name: Requip Other names used:
Active Ingredients:
Therapeutic actions: Requip works by stimulating dopamine receptors in the brain, thus promoting better, easier movement. Requip is not a cure for Parkinson's disease. However, it does alleviate symptoms of the disease, and it can shorten the "off" periods of immobility that patients on long-term levodopa therapy often begin to experience. Indications: Requip helps relieve the signs and symptoms of Parkinson's disease. Caused by a deficit of dopamine (one of the brain's chief chemical messengers), this disorder is marked by progressive muscle stiffness, tremor, and fatigue Contraindications and cautions: At the start of Requip therapy and whenever the dose is increased, you face a slightly increased risk of a fainting spell or other symptoms of low blood pressure such as dizziness, nausea, sweating, and light-headedness, particularly when you get up suddenly after sitting or reclining for a prolonged period. To avoid such symptoms, be careful to stand up slowly. A few patients--especially older ones--also develop hallucinations. Let your doctor know if this occurs. You may have to stop Requip therapy. Use Requip with caution if you have heart disease. There is also a slight chance of developing respiratory difficulties or problems with your eyesight. If you find it hard to breathe, have any swelling, or develop problems with your vision, alert your doctor at once. If you are taking Sinemet with Requip, you may experience jerking muscle movements. Tell your doctor. He will need to decrease your dose of Sinemet. With other Parkinson's medications, a sudden dose reduction has been known to cause high fever, muscle stiffness, and loss of consciousness. Although this has not happened with Requip, be alert for such problems and contact your doctor immediately if they occur. Requip may cause drowsiness, and some people have reported falling asleep without warning during their daily activities. Do not drive a car or operate machinery until you know how the drug affects you. If you find that Requip makes you sleepy or that you're suddenly falling asleep in the middle of routine activities, tell your doctor; he will probably discontinue the drug. Requip may also cause darkening of your skin and eye color. Tell your doctor if you notice any change. Adverse effects: Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Requip. More common side effects may include: Abdominal pain, abnormal dreaming, abnormal muscle movements, abnormal vision, amnesia, anxiety, arthritis, bronchitis, confusion, constipation, decreased muscle movements, diarrhea, difficulty breathing, dizziness, drowsiness, dry mouth, eye problems, fainting, falling, fatigue, hallucinations, headache, increased sweating, indigestion, joint pain, leg swelling, nausea, nervousness, pain, paralysis, respiratory tract infection, runny nose, sinus inflammation, skin tingling, sore throat, swelling, tremor, urinary tract infection, viral infections, vomiting, weakness If Requip gives you an allergic reaction, you will not be able to continue using it. Interactions: If Requip is taken with certain other drugs, the effects of either can be increased, decreased, or altered. It is especially important to check with your doctor before combining Requip with the following:
Additional Information: DO NOT SHARE THIS MEDICINE with others. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS PRODUCT, as well as syringes and needles, if needed during treatment, out of the reach of children. Do not reuse needles, syringes, or other materials. |
盐酸罗匹尼罗片|Requip (ropinirole tablets)简介:
英文药名: Requip (ropinirole tablets)
中文药名: 罗匹尼罗片
生产厂家: Glaxo Smith Kline
【药品名称】
通用名称:盐酸罗匹尼罗片 英文名称:Ropinirole Hydrochloride Tablets, RcQuip, Ropini ... 责任编辑:admin |
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