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【中文品名】甲磺酸培高利特
【药效类别】抗帕金森氏症药
【通用药名】PERGOLIDE MESILATE
【别 名】甲磺酸普果里啶, Celance, LY-127809, Nopor, Parkotil, Permax, Pharken, Pergolide mesylate
【化学名称】 Ergoline, 8-[(methylthio)methyl]-6-propyl-, (8β)-, monomethanesulfonate
【CA登记号】[66104-23-2]
【结 构 式】
【分 子 式】C19H26N2S·CH3SO3H
【分 子 量】410.59
【收录药典】
【开发单位】Eli Lilly (美国)
【首次上市】1989年，美国
【性 状】白色结晶。mp225℃(dec)。
【用 途】
抗帕金森氏症药。为半合成的麦角灵(Ergoline)药物。对多巴胺的剌激作用比溴麦角隐亭作用强而持续时间长，且约有半数对溴麦角隐亭无反应的患者对其有效，仅作为对症治疗剂。并不能根治本症。
甲磺酸培高利特
【英文名称】 Pergolide Mesylate
【其他名称】 倍高利特，倍高利特甲基硫酸盐，甲磺酸倍高利特，培高利特，硫丙麦角林，硫丙麦角林甲烷磺酸盐，普果立得，协良行，Celance，Pergolid，Pergolide Mesilate
【适应证】与溴隐亭相同。
【不良反应】基本与溴隐亭相似，主要有：体位性低血压、幻觉、精神错乱、异动症、食欲减退、恶心、呕吐、腹痛或胃痛、便秘或腹泻、嗜睡、流感样症状、下背部痛、无力等。
【禁忌证】对本品或其他麦角生物碱过敏者禁用。
【注意事项】
1.可抑制乳汁分泌，哺乳期妇女不宜应用本品。对儿童的安全性尚未明。
2.下列情况应慎用：①心律不齐(会增加房性早搏及窦性心动过速的危险性)；②精神疾病(先前已有的精神错乱及幻觉可加重)。
3.服本品期间应随访血压(本品常可降低血压，升高血压则较少见)。
4.进餐时服药可减轻胃刺激。
5.服药后可有嗜睡或眩晕，故不宜驾驶或做危险性工作。
6.逾量的处理：采取对症及支持疗法，可用如下措施：①用活性炭代替或加速胃排空；②如需要可用抗心律失常药，监护心脏功能；③用吩噻嗪或其他神经安定剂治疗中枢神经系统的刺激症状；④维持动脉血压。
【药物相互作用】参见溴隐亭。
【给药说明】
1.应以小剂量开始，逐渐缓慢增量，调节到最低有效量，以避免或减轻副作用的发生。
2.恶心与眩晕常发生在本品开始治疗时，继续治疗后常可消失；但减少培高利特剂量亦可减少或减轻这些副作用的发生率与严重度。于睡前服用首剂药物可使患者更好地耐受眩晕与恶心。进餐时服药亦可减轻恶心。
【用法与用量】开始治疗时0.025mg，每日1次，进餐时服用，以后每隔5日每日增加0.025mg，直至最低有效量，获得最理想的疗效而不出现副作用为止。通常有效剂量每日0.375mg～1.5mg，分次服用，最大量每日不超过2.4mg，在调节本品剂量中，合用的左旋多巴剂量应按临床反应酌情减少。
【制剂与规格】甲磺酸培高利特片：①0.05mg；②0.25mg；③1.0mg。
Pergolide mesylate
Common name: pergolide mesylate (per go, Lide)
Brand Name: Permax
Pergolide mesylate is used for:
When used to treat Parkinson's disease levodopa / carbidopa.
Pergolide mesylate is a dopamine agonist. It does this by stimulating dopamine receptors in the brain.
Pergolide mesylate Do not use if:
Mesylate you are allergic to any ingredient of pergolide
You are allergic to ergot drugs (eg, ergotamine)
Contact your doctor or health care provider right away if any of them apply to you.
Pergolide mesylate prior to use:
Some medical conditions may be associated with pergolide mesylate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
If you are pregnant, planning to become pregnant or are breast-feeding
If you are taking any prescription or non-prescription drugs, herbal preparations, or dietary supplement
If you have allergies to medicines, foods or other substances
If you have heart or kidney problems, irregular heartbeat, lung problems, low blood pressure, or hallucinations history
Some drugs may be pergolide mesylate. Tell your health care provider, especially if you are taking any other drugs the following:
Butyrophenones (such as haloperidol), metoclopramide, phenothiazines (eg, thioridazine), or thioxanthenes (eg thiothixene) pergolide mesylate, may be reduced because the effect of
This may not all interactions that may occur a complete list. Ask your health care provider may pergolide mesylate, if you can take with other medicines. Check with your health care provider before you start, stop or change the dosage of any medicine.
Pergolide mesylate how to use:
Pergolide mesylate with your doctor for instructions. Check the precise dosage instructions on the drug label.
Pergolide mesylate can be taken or without food.
Pergolide mesylate, if you need to stop or if the drug is added to the different treatment of the doctors, it will be gradual. May increase the risk of side effects, if you suddenly stop pergolide mesylate.
If you miss a dose of pergolide acid, can as soon as possible. If your next dose is almost time, skip the missed dose and go back to your regular dose schedule. Do not put a 2.
Ask your health care provider any questions you may have pergolide mesylate how to use.
Important safety information:
Pergolide Mesylate may cause drowsiness, dizziness, or dizziness. Do not drive, operate machinery, or do any other could be dangerous until you know your response to pergolide mesylate. Pergolide mesylate alone, with certain other drugs, alcohol, or may lessen your ability to drive or perform other potentially dangerous tasks.
Pergolide Mesylate may cause dizziness, fainting. Alcohol, hot weather, exercise, and fever can increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Also, sit or lie down and when the dizziness, chest tightness, or weak evidence of the.
Avoid drinking alcohol or taking cause drowsiness (such as tranquilizers, sedatives), pergolide mesylate, while taking other drugs. Pergolide mesylate to increase the influence of alcohol and other depressants. Ask your pharmacist if you have questions about the drugs are sedatives.
Neuroleptic Malignant Syndrome (NMS) is a potentially fatal pergolide mesylate syndrome, if you suddenly stop taking, or if you lower the dose too quickly. Symptoms may include increased body heat, stiff muscles, changes in mental abilities, including lack of response to your surroundings, fast or irregular heartbeat, sweating. Contact your doctor immediately if these symptoms occur. Do not stop taking it without first use of pergolide mesylate to talk to your doctor.
Use of pergolide mesylate in the elderly care, because they may be more sensitive to its effects, especially confusion.
Pergolide mesylate is not recommended for children. Safety and effectiveness have not yet determined.
Pregnancy and breast-feeding: It is unknown pergolide mesylate, and if we can cause fetal harm. If you become pregnant Pergolide mesylate when taking a doctor to discuss pregnancy with the use of pergolide mesylate in the benefits and risks. This is pergolide mesylate is unknown if excreted in breast milk. Do not breast-feeding taking pergolide mesylate.
If you suddenly stop taking pergolide mesylate, you may experience anxiety, muscle twitching, trembling hands and fingers, weakness, dizziness, hallucinations, nausea, vomiting, insomnia, chest tightness, or seizures withdrawal symptoms .
Pergolide mesylate possible side effects:
All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if these most common side effects persist or become any annoyance:
Anxiety, constipation, diarrhea, insomnia, dizziness, drowsiness, dry mouth, dizziness, loss of appetite, nausea, pain, runny nose, stomach pain, stomach discomfort.
Immediate medical attention, if these serious side effects occur:
Severe allergic reaction (rash, hives, difficulty breathing; tension in the chest, mouth, face, lips swelling, or tongue); chest pain; confusion; syncope, seizures increased action; leg or foot swelling, see or hear the strange things (hallucinations), severe dizziness or lightheadedness, difficulty breathing, abnormal weakness, unusually slow, fast or irregular heartbeat.
This is not all the side effects may occur a complete list. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA 1 - 800 - U.S. FDA - 1088 (1-800-332-1088) or
If overdose suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/DNN/), or emergency room. Symptoms may include agitation, rapid or irregular heartbeat, hallucinations, nausea, seizures; tingling or uncontrolled movement of arms and legs, unusual dizziness or fainting, vomiting
Pergolide mesylate properly stored:
Pergolide mesylate stored at room temperature, 68 to 77 degrees Fahrenheit (20 and 25 degrees C). Store away from heat, moisture, light. Do not store in the bathroom. Pergolide mesylate to keep out of reach of children and away from pets.
General information:
If you pergolide mesylate any questions, please contact your doctor, pharmacist or other health care providers talk.
Pergolide mesylate is used by the patient, and this is the only requirement. Do not share it with others.
If your symptoms do not improve, or they are more serious, check with your doctor.
This information is a summary only. It does not contain all of pergolide mesylate information. If you have questions about the drugs you are taking or would like more information, contact your doctor, pharmacist or other health service delivery issues
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