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英文药名: Teveten(Eprosartan Tablets)
中文药名: 依普罗沙坦片
生产厂家: Solvay Pharma
药品名称
中文通用名称: 依普罗沙坦
英文通用名称: Eprosartan, Teveten
其 它 名 称: 依普沙坦, 依普沙坦片, Eprosartan Tablets, 泰絡欣
产 品 分 类: 西药\心血管系统用药\降血压药\肾素－血管紧张素系统抑制药\血管紧张素Ⅱ受体阻滞药
适应症
用于原发性高血压，可单独用作一线治疗或与噻嗪类利尿药联用(国外资料)。
用法用量
[国外用法用量参考]
成人
•常规剂量
•口服给药原发性高血压：
(1)无血容量不足的患者单用本药治疗的常用初始剂量为一次600mg，一日1次。一日给药总量为400-800mg，分1-2次服用。剂量超过800mg的使用经验有限。
(2)对波谷时测量血压无充分治疗反应的患者，一日2次的给药方案或增加剂量可能产生更佳的抗高血压作用，2-3周可能达到最大降压效应。
(3)一日400-800mg，1次或分2次服用，对降低坐位舒张压至目标水平的疗效相似。
•肾功能不全时剂量
(1)轻度肾脏损害者不必调整初始剂量。
(2)中、重度肾脏损害者对本药的平均肾清除率下降40%-95%，必须调整剂量。
•肝功能不全时剂量
肝脏损害者不必调整初始剂量。
•老年人剂量
(1)不必调整初始剂量。
(2)一项对65-90岁老人的研究提示，一次100-200mg，一日2次，安全而有效。
任何疑问, 请遵医嘱!
不良反应
[国外不良反应参考]
1.心血管系统血管紧张素Ⅱ受体拮抗药(ARA)可致麻醉时低血压发生增多。试验发现，与ACEI(n=27)、β肾上腺素受体阻断药或钙通道拮抗药(n=45)比较，长期使用ARA的患者(n=12)在血管外科手术麻醉诱导后低血压的发生率和严重程度均显著增加，同时也需要更大的麻黄碱剂量来恢复血压水平。
2.中枢神经系统据报道，最常见头痛(3.8%)、眩晕(2.4%)和疲乏(1.4%)，但总发生率与使用安慰剂无显著差异。
3.代谢/内分泌系统
(1)有报道，使用本药每日600mg，不改变轻中度原发性高血压患者的尿酸/肌酸酐(Ur/Cr)比率、尿酸的排泄或血尿酸水平。
(2)男性轻度高血压患者(n=57)使用本药一日50-1200mg，疗程1周，无论单剂或多剂给药均对血尿酸或尿酸的分级排泄无影响。
4.呼吸系统临床试验中出现咳嗽(1.8%-6.5%)，但发生率与安慰剂对照组无显著差异。
5.肌肉骨骼系统临床试验中有肌痛(1.9%)的报道，但总发生率与安慰剂组无显著差异。
6.皮肤可见面部水肿。
注意事项
1.禁忌症
(1)对本药过敏者(国外资料)。
(2)孕妇(国外资料)。
2.慎用
(1)有血管紧张素转换酶抑制药(ACEI)、阿司匹林、青霉素过敏史。
(2)主动脉瓣(或二尖瓣)狭窄或肥厚型心肌病。
(3)低血压。
(4)肝功能不全、胆汁性肝硬化或胆道梗阻。
(5)肾功能不全或肾动脉狭窄(单侧肾或双侧肾)。
(6)高钾血症。
(7)需全身麻醉的外科手术。(以上均选自国外资料)
3.药物对老人的影响老年人对本药的吸收增加，大于65岁老年人的曲线下面积(AUC)和Cmax约增加2倍。
4.药物对妊娠的影响美国食品药品管理局(FDA)对本药的妊娠安全性分级为C级(妊娠早期)和D级(妊娠中晚期)。如发现使用本药治疗的患者开始妊娠，应停用本药并换用其他药物。如不能选择其他抗高血压药物，应告知患者继续治疗的风险，同时应经常做超声波检查，并监测患者是否出现羊水过少。
5.药物对哺乳的影响尚不明确本药是否经乳汁分泌。
规格
甲磺酸依普罗沙坦片(1)400mg。(2)600mg。
【原产地英文商品名】TEVETEN 600mg/tab 100tabs/bottle
【原产地英文药品名】EPROSARTAN MESYLATE
【中文参考商品译名】
注：以下产品不同规格和不同价格，购买时请以电话咨询为准！
·TEVETEN 400毫克/片 100片/瓶
·TEVETEN 600毫克/片 100片/瓶
【中文参考药品译名】甲磺酸依普沙坦
【生产厂家中文参考译名】雅培
【生产厂家英文名】ABBOTT
Teveten (eprosartan)
Main use：High blood pressure
Active ingredient：Eprosartan mesylate
How does it work?
Teveten tablets contain the active ingredient eprosartan, which is a type of medicine called an angiotensin II blocker. It works by preventing the action of a hormone in the body called angiotensin II.
Angiotensin II normally acts on special receptors in the body, with two main results. Firstly, it causes the peripheral blood vessels to narrow, and secondly, it stimulates the production of another hormone called aldosterone. Aldosterone causes salt and water to be retained by the kidneys, which increases the volume of fluid in the blood vessels.
Eprosartan blocks the receptors that angiotensin II acts on, and so prevents its actions. The main result of this is that the peripheral blood vessels are allowed to widen, which means that there is more space and less resistance in these blood vessels. This is the main mechanism by which the pressure in the blood vessels is lowered.
Blocking the actions of angiotensin II also reduces the action of aldosterone on the kidneys. The result of this is an increase in the amount of fluid removed from the blood by the kidneys. This decreases the amount of fluid in the blood vessels, which also lessens the resistance and pressure in the blood vessels.
The combined overall effect of these changes is to lower the blood pressure.
What is it used for?
High blood pressure with no known cause (essential hypertension).
Warning!
Teveten tablets should be taken with or after food.
Dizziness and weariness may occasionally occur during treatment with blood pressure lowering medicines. Dizziness can be relieved by lying down until the symptoms pass. If you are affected, caution is required when driving or operating machinery.
People with decreased kidney function should have regular blood tests to monitor the levels of potassium and creatinine in their blood while taking this medicine.
Use with caution in
Elderly people over 75 years
Decreased kidney function
Narrowing of the artery that supplies blood to the kidneys (renal artery stenosis)
Mild to moderately decreased liver function
People with low fluid volume or salt levels in the body, eg due to diuretic therapy, low-sodium diet, diarrhoea or vomiting.
Not to be used in
Severely decreased liver function
Pregnancy
Breastfeeding.
The safety and efficacy of this medicine have not been studied in children. It is not recommended for children.
This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Pregnancy and breastfeeding
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
This medicine should not be used during pregnancy, as it may be harmful to the developing baby. Seek medical advice from your doctor. If you do fall pregnant you should stop taking this medicine and consult your doctor immediately.
It is not known if this medicine passes into breast milk. It should not be used by women who are breastfeeding. Seek further medical advice from your doctor.
Label warnings
Take this medication with or after food.
Side effects
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
Dizziness
Pain in the joints (arthralgia)
Inflammation of the lining of the nose (rhinitis) causing a blocked or runny nose
Excess gas in the stomach and intestines (flatulence)
Raised levels of triglycerides in the blood (hypertriglyceridaemia)
High blood potassium level (hyperkalaemia)
Headache
Feeling of weakness
Skin reactions such as rash or itching
Nausea
Severe swelling of lips, face or tongue (angioedema)
Low blood pressure (hypotension)
The side effects listed above may not include all of the side effects reported by the drug's manufacturer.
For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
How can this medicine affect other medicines?
It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe.
If this medicine is taken with other medicines that decrease blood pressure, either as a treatment for high blood pressure or as a side effect, the effects on blood pressure are likely to be additive. If your blood pressure falls too low it might make you feel dizzy, in which case lie down until the feeling passes and let your doctor know, in case your doses need adjusting.
If you are already taking a high dose of a diuretic medicine, eg furosemide, your doctor may need to reduce its dose before you start this medicine, to avoid causing a large drop in blood pressure that might result in dizziness or fainting.
This medicine may increase the blood level of the medicine lithium. If you take this medicine in combination with lithium it is recommended that the level of lithium in your blood is closely monitored.
There may be a risk of raised blood potassium levels (hyperkalaemia) if this medicine is taken with any of the following:
ciclosporin
heparin
potassium-sparing diuretics (eg spironolactone, triamterene, amiloride)
potassium supplements
potassium salts, eg potassium citrate
potassium-containing salt substitutes, eg Lo-salt.
The amount of potassium in your blood should be regularly monitored if you take any of these with this medicine, particularly if you have any problems with your kidneys.
Non-steroidal anti-inflammatory drugs (NSAIDs, eg ibuprofen, diclofenac, indometacin) may reduce the blood pressure lowering effect of eprosartan. They may also increase the risk of raised blood potassium and kidney problems when used in combination with eprosartan. NSAIDs should be used with caution in people taking eprosartan, particularly elderly people, and your doctor may want to monitor your kidney function if you do regularly take an NSAID with this medicine.
Other medicines containing the same active ingredient
There are currently no other medicines available in the UK that contain eprosartan as the active ingredient. | 
